Evaluation of Topical Monotherapy for Early Primary Open Angle Glaucoma Patient

2018 ◽  
Vol 70 (3) ◽  
pp. 403-408 ◽  
Author(s):  
Saber Hamed El-Saied ◽  
Adel Galal Zaky ◽  
Ahmed El-Refaie Ali Abou El-Agha
Keyword(s):  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Glaucoma Patient ◽  
Open Angle ◽  
Early Primary

scholarly journals Glaucomatous Maculopathy: Thickness Differences on Inner and Outer Macular Layers between Ocular Hypertension and Early Primary Open-Angle Glaucoma Using 8 × 8 Posterior Pole Algorithm of SD-OCT

2020 ◽  
Vol 9 (5) ◽  
pp. 1503 ◽  
Author(s):  
Jose Javier Garcia-Medina ◽  
Monica del-Rio-Vellosillo ◽  
Ana Palazon-Cabanes ◽  
Maria Dolores Pinazo-Duran ◽  
Vicente Zanon-Moreno ◽  
...  
Keyword(s):  
Ocular Hypertension ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Retinal Pigment ◽  
Posterior Pole ◽  
Inner Plexiform Layer ◽  
Open Angle ◽  
Retinal Layers ◽  
Early Primary ◽  
Sd Oct

The purpose of this study was to compare the thickness of all inner and outer macular layers between ocular hypertension (OHT) and early primary open-angle glaucoma (POAG) using spectral domain optical coherence tomography (SD-OCT) 8 × 8 posterior pole algorithm (8 × 8 PPA). Fifty-seven eyes of 57 OHT individuals and fifty-seven eyes of 57 early POAG patients were included. The thickness of macular retinal nerve fiber layer (mRNFL), ganglion cell layer (GCL), inner plexiform layer (IPL), inner nuclear layer (INL), outer plexiform and nuclear layer, photoreceptor layer (PRL) and retinal pigment epithelium were obtained in 64 cells for each macular layer and mean thickness of superior and inferior hemispheres was also calculated. Thinning of superior and inferior hemisphere mean thickness in mRNFL, GCL and IPL and thickening of superior and inferior hemisphere mean thickness in PRL and inferior hemisphere in INL were found in early GPAA group. Otherwise, heatmaps representing cell-to-cell comparisons showed thinning patterns in inner retinal layers (except for INL) and thickening patterns in outer retinal layers in GPAA group. We found that 8 × 8 PPA not only allows the detection of significant thinning patterns in inner retinal layers, but also thickening patterns in outer retinal layers when comparing early POAG eyes to OHT eyes.

scholarly journals Canaloplasty in the Treatment of Primary Open-Angle Glaucoma: Patient Selection and Perspectives

2019 ◽  
Vol Volume 13 ◽  
pp. 2617-2629 ◽  
Author(s):  
Anna Byszewska ◽  
Joanna Konopińska ◽  
Aleksandra Kinga Kicińska ◽  
Zofia Mariak ◽  
Marek Rękas
Keyword(s):  
Patient Selection ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Glaucoma Patient ◽  
Open Angle

Automated flicker perimetry in early primary open-angle glaucoma

1996 ◽  
Vol 24 ◽  
pp. 25-27 ◽  
Author(s):  
Alice Rota-Bartelink ◽  
Alison Pitt ◽  
Ian Story ◽  
Julian Rait
Keyword(s):  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Open Angle ◽  
Early Primary

Hemodynamic changes in eyes with early primary open-angle glaucoma measured by transpalpebral rheoophthalmography

2016 ◽  
Vol 94 ◽  
Author(s):  
A. Kleyman ◽  
O. Kiseleva ◽  
E. Iomdina ◽  
A. Bessmertny ◽  
P. Luzhnov ◽  
...  
Keyword(s):  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Open Angle ◽  
Hemodynamic Changes ◽  
Early Primary

Measurements of OCTA Complement OCT for Diagnosing Early Primary Open Angle Glaucoma

2021 ◽  
Author(s):  
Alireza Kamalipour ◽  
Sasan Moghimi ◽  
Cris Martin Jacoba ◽  
Adeleh Yarmohammadi ◽  
Kaileen Yeh ◽  
...  
Keyword(s):  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Open Angle ◽  
Early Primary

Impaired Complex-I-Linked Respiration and ATP Synthesis in Primary Open-Angle Glaucoma Patient Lymphoblasts

2012 ◽  
Vol 53 (4) ◽  
pp. 2431 ◽  
Author(s):  
Shanjean Lee ◽  
Leo Sheck ◽  
Jonathan G. Crowston ◽  
Nicole J. Van Bergen ◽  
Evelyn C. O'Neill ◽  
...  
Keyword(s):  
Complex I ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Glaucoma Patient ◽  
Atp Synthesis ◽  
Open Angle

scholarly journals Age at Glaucoma Diagnosis in Germline Myocilin Mutation Patients: Associations with Polymorphisms in Protein Stabilities

Genes ◽  
2021 ◽  
Vol 12 (11) ◽  
pp. 1802
Author(s):  
Tarin Tanji ◽  
Emily Cohen ◽  
Darrick Shen ◽  
Chi Zhang ◽  
Fei Yu ◽  
...  
Keyword(s):  
Risk Factor ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Glaucoma Patient ◽  
Open Angle ◽  
Clinical Factors ◽  
Weak Correlation ◽  
Melting Temperatures ◽  
Glaucoma Diagnosis ◽  
Elevated Intraocular Pressure

Glaucoma is the leading cause of irreversible blindness worldwide, with elevated intraocular pressure (IOP) as the only known modifiable risk factor. Trabecular meshwork (TM)-inducible myocilin (the MYOC gene) was the first to be identified and linked to juvenile and primary open-angle glaucoma. It has been suggested that mutations in the MYOC gene and the aggregation of mutant myocilin in the endoplasmic reticulum (ER) of TM may cause ER stress, resulting in a reduced outflow of aqueous humor and an increase in IOP. We selected 20 MYOC mutations with experimentally determined melting temperatures of mutated myocilin proteins. We included 40 published studies with at least one glaucoma patient with one of these 20 MYOC mutations and information on age at glaucoma diagnosis. Based on data from 458 patients, we found that a statistically significant but weak correlation was present between age and melting temperature based on various assumptions for age. We therefore conclude that genetic analysis of MYOC mutations alone cannot be used to accurately predict age at glaucoma diagnosis. However, it might be an important prognostic factor combined with other clinical factors for critical and early detection of glaucoma.

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