scholarly journals Manganese Neurotoxicity: Lessons Learned from Longitudinal Studies in Nonhuman Primates

2009 ◽  
Vol 117 (3) ◽  
pp. 325-332 ◽  
Author(s):  
Neal C. Burton ◽  
Tomás R. Guilarte
2014 ◽  
Vol 83 (3) ◽  
pp. 852-862 ◽  
Author(s):  
Juliet C. Peña ◽  
Wen-Zhe Ho

The use of animal models has been invaluable for studying the pathogenesis ofMycobacterium tuberculosisinfection, as well as for testing the efficacy of vaccines and drug regimens for tuberculosis. Among the applied animal models, nonhuman primates, particularly macaques, share the greatest anatomical and physiological similarities with humans. As such, macaque models have been used for investigating tuberculosis pathogenesis and preclinical testing of drugs and vaccines. This review focuses on published major studies which illustrate how the rhesus and cynomolgus macaques have enriched and may continue to advance the field of global tuberculosis research.


2009 ◽  
Vol 71 (9) ◽  
pp. 785-793 ◽  
Author(s):  
Thomas B. Clarkson ◽  
Margaret H. Mehaffey

2020 ◽  
Author(s):  
Emily B Ferris ◽  
Katarzyna Wyka ◽  
Kelly R. Evenson ◽  
Joan M Dorn ◽  
Lorna Thorpe ◽  
...  

UNSTRUCTURED Longitudinal, natural experiments provide an ideal evaluation approach to better understand the impact of built environment interventions on community health outcomes, particularly heath disparities. As there are many recruitment and retention challenges inherent to the design of longitudinal, natural experiments, adaptive and iterative recruitment and retention strategies are critical to the success of a study. This paper documents lessons learned from the Physical Activity and Redesigned Community Spaces (PARCS) Study. The PARCS Study, while ongoing, has developed several approaches to improve the recruitment and retention protocols by prioritizing the following four dimensions: 1) building trust with communities; 2) adapting the study protocol to meet participants’ needs and to reflect their capacity for participation; 3) operational flexibility; and 4) measurement and evaluation systems. These strategies may help researchers more successfully recruit and retain participants, particularly in low-income, minority neighborhoods, into longitudinal studies.


Author(s):  
Sebastian Heinzel ◽  
Benjamin Roeben ◽  
Yoav Ben-Shlomo ◽  
Stefanie Lerche ◽  
Guido Alves ◽  
...  

2009 ◽  
Vol 23 (1) ◽  
pp. 19-24 ◽  
Author(s):  
Toru Murakami ◽  
A. Benedict Cosimi ◽  
Tatsuo Kawai

2003 ◽  
Vol 8 (1) ◽  
pp. 29-41 ◽  
Author(s):  
Mary F. Sinclair ◽  
Sandra L. Christenson ◽  
Camilla A. Lehr ◽  
Amy Reschly Anderson

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