scholarly journals Elevated nitric oxide/peroxynitrite theory of multiple chemical sensitivity: central role of N-methyl-D-aspartate receptors in the sensitivity mechanism.

2003 ◽  
Vol 111 (12) ◽  
pp. 1461-1464 ◽  
Author(s):  
Martin L Pall
Keyword(s):  
Nitric Oxide ◽  
Multiple Chemical Sensitivity ◽  
Chemical Sensitivity ◽  
Multiple Chemical

PON1 polymorphisms can predict generalized anxiety and depressed mood in patients with multiple chemical sensitivity

2021 ◽  
Author(s):  
Alessio Mosca ◽  
Antonio Del Casale ◽  
Marina Borro ◽  
Giovanna Gentile ◽  
Leda Marina Pomes ◽  
...  
Keyword(s):  
Multiple Chemical Sensitivity ◽  
Anxiety And Depression ◽  
Generalized Anxiety ◽  
Chemical Sensitivity ◽  
Chemical Agents ◽  
Affective Symptoms ◽  
Pon1 Polymorphisms ◽  
Toxic Concentrations ◽  
Multiple Chemical

Background: Multiple chemical sensitivity (MCS) is a chronic condition with somatic, cognitive and affective symptoms that follow contact with chemical agents at usually non toxic concentrations. We aimed to assess the role of genetic polymorphisms involved in oxidative stress on anxiety and depression in MCS. Materials & methods: Our study investigated the CAT rs1001179, MPO rs2333227, PON1 rs662 and PON1 rs705379 polymorphisms in MCS. Results: The AG genotype of the PON1 rs662 and the TT and CT genotypes of the PON1 rs705379 were involved in anxiety and depression. Discussion: These results are in line with existing evidence of PON1 involvement in MCS and suggest a further role of this gene in the exhibition of anxiety and depression in this disease.

Ambient Scenting, Architecture, and the City

Art Scents ◽  
2020 ◽  
pp. 278-295
Author(s):  
Larry Shiner
Keyword(s):  
Urban Design ◽  
Ethical Issues ◽  
Multiple Chemical Sensitivity ◽  
Chemical Sensitivity ◽  
Modern City ◽  
Developed World ◽  
The City ◽  
Multiple Chemical

Chapter 14 argues that the ethos of the modern city in the developed world is marked by a conflict between an established tendency toward “deodorizing” and a minority of scent advocates who seek greater olfactory diversity. The chapter begins by discussing smellwalking, smell mapping, and related artworks, then moves on to the place of odors in urban design, noting that most city officials think of odors only as something to be controlled or eliminated. After a discussion of the role of smell in architecture, the chapter closes by considering the ethical issues surrounding ambient scenting in both the workplace and the marketplace, as well as the clash between claims made for aromatherapy and the demand for fragrance bans made by sufferers from multiple chemical sensitivity.

PET in patients with clear-cut multiple chemical sensitivity (MCS)

2002 ◽  
Vol 41 (06) ◽  
pp. 233-239 ◽  
Author(s):  
C. Hausteiner ◽  
A. Drzezga ◽  
P. Bartenstein ◽  
M. Schwaiger ◽  
H. Förstl ◽  
...  
Keyword(s):  
Single Photon ◽  
Photon Emission ◽  
Multiple Chemical Sensitivity ◽  
Environmental Chemicals ◽  
Chemical Sensitivity ◽  
Clear Cut ◽  
Positron Emission ◽  
Symptom Complex ◽  
Brain Changes ◽  
Multiple Chemical

SummaryAim: Multiple chemical sensitivity (MCS) is a controversially discussed symptom complex. Patients afflicted by MCS react to very low and generally nontoxic concentrations of environmental chemicals. It has been suggested that MCS leads to neurotoxic damage or neuroimmunological alteration in the brain detectable by positron emission tomography (PET) and single photon emission computer tomography (SPECT). These methods are often applied to MCS patients for diagnosis, although they never proved appropriate. Method: We scanned 12 MCS patients with PET, hypothesizing that it would reveal abnormal findings. Results: Mild glucose hypometabolism was present in one patient. In comparison with normal controls, the patient group showed no significant functional brain changes. Conclusion: This first systematic PET study in MCS patients revealed no hint of neurotoxic or neuroimmuno-logical brain changes of functional significance.

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