scholarly journals Effect of Combination Therapy of Angiotensin-Converting Enzyme Inhibitor plus Calcium Channel Blocker on Urinary Albumin Excretion in Hypertensive Microalubuminuric Patients with Type II Diabetes.

2000 ◽  
Vol 23 (3) ◽  
pp. 219-226 ◽  
Author(s):  
Toshikatsu SHIGIHARA ◽  
Atsuhisa SATO ◽  
Koichi HAYASHI ◽  
Takao SARUTA
Keyword(s):  
Combination Therapy ◽  
Angiotensin Converting Enzyme ◽  
Calcium Channel ◽  
Type Ii Diabetes ◽  
Channel Blocker ◽  
Urinary Albumin Excretion ◽  
Enzyme Inhibitor ◽  
Urinary Albumin ◽  
Type Ii ◽  
Converting Enzyme

scholarly journals Effect of Combination Therapy with a Calcium Channel Blocker and an Angiotensin-Converting Enzyme Inhibitor on Renal Hypertrophy and Urinary Albumin Excretion in Diabetic Rats

2003 ◽  
Vol 4 (3) ◽  
pp. 191-199 ◽  
Author(s):  
Birgitte Nielsen ◽  
Henning Grønbæk ◽  
Ruth Østerby ◽  
Allan Flyvbjerg
Keyword(s):  
Angiotensin Converting Enzyme ◽  
Calcium Channel ◽  
Calcium Channel Blocker ◽  
Channel Blocker ◽  
Urinary Albumin Excretion ◽  
Placebo Treatment ◽  
Diabetic Rats ◽  
Urinary Albumin ◽  
Converting Enzyme ◽  
Albumin Excretion

The objective of this study was to compare the effect of an angiotensin-converting enzyme (ACE) inhibitor and a calcium channel blocker on the development of renal changes in diabetic rats. Diabetes was induced by an intravenous injection of streptozotocin in normotensive Wistar rats. Treatment was commenced immediately in 1 set of rats with 4 treatment arms: nitrendipine (250 mg/kg fodder), enalapril (35 mg/L drinking water), both treatments in combination, or placebo. Treatment was continued for 9 weeks. Another set of rats was left with untreated diabetes for 3 months followed by 7 weeks treatment as above. When starting treatment right after induction of diabetes, nitrendipine significantly reduced urinary albumin excretion (UAE) to the nondiabetic level (P< .05) without reducing blood pressure (BP), whereas enalapril failed to significantly reduce UAE despite a reduction in BP. Combining the two treatments showed no further reduction in UAE compared to monotherapy with nitrendipine, despite a lower BP. When leaving diabetic rats untreated for 3 months, only the coadministration of nitrendipine and enalapril showed a significant reduction in UAE compared to monotherapy and placebo treatment, but showed no significant effect on BP.

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