First known case of successful pressure ulcer treatment in a lung transplant patient with post-COVID-19 pneumonia

2021 ◽  
Vol 30 (8) ◽  
pp. 594-597
Author(s):  
Yilan Tong ◽  
Sijiong Yu ◽  
Kaijun Guo ◽  
Xiangsheng Wang ◽  
Yang Wu ◽  
...  
Keyword(s):  
Lung Transplant ◽  
Transplant Patient ◽  
Myocutaneous Flap ◽  
Clinical Manifestations ◽  
Gluteus Maximus ◽  
Wound Therapy ◽  
Skin Tension ◽  
Transplant Patients ◽  
Relief System ◽  
Ulcer Treatment

Given the current COVID-19 crisis, multiple clinical manifestations and related complications of COVID-19 disease, especially in lung transplant patients following post-COVID-19 pneumonia, are a major challenge. Herein, we report the therapeutic course of the first reported case of sacrococcyx pressure ulcers (PU) in a 65-year-old male COVID-19 patient who underwent lung transplantation and developed a PU following surgery. We used a combination of regulated negative pressure-assisted wound therapy system (RNPT, six treatment courses, five days per treatment course), a skin tension-relief system (an intraoperative aid in minimising wounds caused by sacrococcygeal PUs) and a gluteus maximus myocutaneous flap to repair sacrococcygeal wounds. This successfully treated case provides a reference point for the treatment of similar cases.

scholarly journals Successful treatment of a kidney transplant patient with COVID-19 and late-onset Pneumocystis jirovecii pneumonia

2021 ◽  
Author(s):  
Jing Peng ◽  
Ming Ni ◽  
Dunfeng Du ◽  
Yanjun Lu ◽  
Juan Song ◽  
...  
Keyword(s):  
Kidney Transplant ◽  
Successful Treatment ◽  
Transplant Patient ◽  
Late Onset ◽  
Clinical Manifestations ◽  
Pneumocystis Jirovecii ◽  
Pneumocystis Jirovecii Pneumonia ◽  
Kidney Transplant Patient ◽  
Transplant Patients ◽  
Kidney Transplant Patients

Abstract Background: Solid transplant patients are susceptible to Pneumocystis jirovecii pneumonia (PJP). While the vast majority of PJP cases occur within the first 6 months after transplantation, very few PJP cases are seen beyond 1 year post transplantation (late-onset PJP). PJP and coronavirus disease 2019 (COVID-19, caused by infection with SARS-CoV-2) share quite a few common clinical manifestations and imaging findings, making the diagnosis of PJP often underappreciated during the current COVID-19 pandemic. To date, only 1 case of kidney transplantation who developed COVID-19 and late-onset PJP has been reported, but this patient also suffered from many other infections and died from respiratory failure and multiple organ dysfunction syndrome. A successful treatment of kidney patients with COVID-19 and late-onset PJP has not been reported. Case presentation: We present a case of a 55-year-old male kidney transplant patient with COVID-19 who also developed late-onset PJP. He received a combined strategy, including specific anti-pneumocystis therapy, symptomatic supportive therapy, adjusted immunosuppressive therapy, and use of antiviral/antibiotics drugs, ending with a favorable outcome. Conclusions: This case highlights the importance of prompt and differential diagnosis of PJP in kidney transplant patients with SARS-CoV-2 infection. Further studies are required to clarify if kidney transplant patients with COVID-19 could be prone to develop late-onset PJP and how these patients should be treated.

Use of topical sevoflurane in pressure ulcer treatment in a double-lung transplant patient

2020 ◽  
Author(s):  
Carolina Hidalgo-Doniga ◽  
Candelas Lopez-Lopez ◽  
Violeta Pajero Otero ◽  
Maria Elena Garcia Manzanares ◽  
Laura Collados-Gomez ◽  
...  
Keyword(s):  
Pressure Ulcer ◽  
Lung Transplant ◽  
Transplant Patient ◽  
Ulcer Treatment

Cytomegalovirus Infection Masquerading as Carcinoma in a Lung Transplant Patient

2005 ◽  
Vol 129 (1) ◽  
pp. e1-e3
Author(s):  
Timothy Craig Allen ◽  
Remzi Bag ◽  
Dani S. Zander ◽  
Philip T. Cagle
Keyword(s):  
Cell Carcinoma ◽  
Cytomegalovirus Infection ◽  
Lung Transplant ◽  
Transplant Patient ◽  
Superior Mediastinum ◽  
Transplant Patients ◽  
Bilateral Lung Transplantation ◽  
Eosinophilic Cytoplasm ◽  
Lung Infections ◽  
Bilateral Lung

Abstract In lung transplant patients, most infections produce radiographically diffuse or lobar infiltrates. Solitary nodules suggesting neoplasm may arise in lung transplant patients with lung infections. We describe a 45-year-old woman who underwent bilateral lung transplantation to treat bilateral bronchiectasis and lung fibrosis resulting from Hodgkin disease. Five months later, a solitary mass was identified on chest radiograph in the left upper lobe and left superior mediastinum. Low-power examination of wedge biopsies of the mass showed a florid proliferation of cells with clear to bubbly to eosinophilic cytoplasm and moderate nuclear atypia, proliferating fibroblasts, and necrosis, suggesting a clear cell carcinoma (possibly metastatic renal cell carcinoma). Intranuclear inclusions compatible with cytomegalovirus were identified on high-power examination and confirmed by immunohistochemistry. In lung transplant patients, a cytomegalovirus infection may mimic malignancy both radiographically and on initial histopathologic examination.

Morbidity and Mortality after General Surgery in Heart and Lung Transplant Patients

2019 ◽  
Author(s):  
Alek Zywot ◽  
Amber L. Turner ◽  
Joanna Sesti ◽  
Russell C. Langan ◽  
Andrew Nguyen ◽  
...  
Keyword(s):  
General Surgery ◽  
Lung Transplant ◽  
Morbidity And Mortality ◽  
Transplant Patients

Early post–lung transplant patient presenting with an incidental abdominal finding on a chest x‐ray

2021 ◽  
Vol 21 (3) ◽  
pp. 1340-1342
Author(s):  
Abbas Shahmohammadi ◽  
Martin Rosenthal ◽  
Mauricio Pipkin ◽  
Tiago N. Machuca
Keyword(s):  
Lung Transplant ◽  
Transplant Patient ◽  
X Ray ◽  
Chest X Ray

scholarly journals Twelve-month effects of everolimus on renal and lung function in lung transplantation: differences in chronic lung allograft dysfunction phenotypes

2021 ◽  
Vol 12 ◽  
pp. 204062232199344
Author(s):  
Filippo Patrucco ◽  
Elias Allara ◽  
Massimo Boffini ◽  
Mauro Rinaldi ◽  
Cristina Costa ◽  
...  
Keyword(s):  
Renal Function ◽  
Lung Function ◽  
Lung Transplant ◽  
Bronchiolitis Obliterans Syndrome ◽  
Forced Expiratory Volume ◽  
Chronic Lung Allograft Dysfunction ◽  
Allograft Dysfunction ◽  
Transplant Patients ◽  
Restrictive Allograft Syndrome ◽  
Trend Data

Background: Chronic lung allograft dysfunction (CLAD), a complication affecting the survival of lung transplanted patients, includes two clinical phenotypes: bronchiolitis obliterans syndrome (BOS) and restrictive allograft syndrome (RAS). Everolimus is used in CLAD because of its antiproliferative mechanism. In lung transplant patients treated with everolimus, the clinical course of renal and lung function has not yet been assessed systematically in CLAD, BOS and RAS patients for more than 6 months. Methods: We retrospectively evaluated the 12-month follow-up of renal and lung function of lung-transplanted patients switched to everolimus and evaluated the reduction in immunosuppressant dosage (ISD) and mortality. Subgroups were based on indication for everolimus treatment: CLAD and non-CLAD patients, BOS and RAS among CLAD patients. Results: We included 26 patients, 17 with CLAD (10 BOS, seven RAS). After 1 year from the everolimus switch, we observed renal function improvement (serum creatinine −17%, estimated glomerular filtration rate +24%) and stable pulmonary function [forced expiratory volume in the first second (FEV1) −0.5%, forced vital capacity (FVC) +0.05%]. RAS patients had progressive functional loss, whereas BOS patients had FEV1 improvement and FVC stability. All-cause mortality was higher in the CLAD versus non-CLAD group (41% versus 11%), without differences between BOS and RAS patients ( p > 0.05). All patients had significant and persistent ISD reduction. Conclusion: Lung transplant patients treated with everolimus had improvements in renal function and reduced ISD. We observed sustained improvements in lung function for CLAD related to BOS subgroup results, whereas RAS confirmed the 1-year worsening functional trend. Data seem to suggest one more piece of the puzzle in CLAD phenotyping.

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