Cytomegalovirus Infection Masquerading as Carcinoma in a Lung Transplant Patient

2005 ◽  
Vol 129 (1) ◽  
pp. e1-e3
Author(s):  
Timothy Craig Allen ◽  
Remzi Bag ◽  
Dani S. Zander ◽  
Philip T. Cagle
Keyword(s):  
Cell Carcinoma ◽  
Cytomegalovirus Infection ◽  
Lung Transplant ◽  
Transplant Patient ◽  
Superior Mediastinum ◽  
Transplant Patients ◽  
Bilateral Lung Transplantation ◽  
Eosinophilic Cytoplasm ◽  
Lung Infections ◽  
Bilateral Lung

Abstract In lung transplant patients, most infections produce radiographically diffuse or lobar infiltrates. Solitary nodules suggesting neoplasm may arise in lung transplant patients with lung infections. We describe a 45-year-old woman who underwent bilateral lung transplantation to treat bilateral bronchiectasis and lung fibrosis resulting from Hodgkin disease. Five months later, a solitary mass was identified on chest radiograph in the left upper lobe and left superior mediastinum. Low-power examination of wedge biopsies of the mass showed a florid proliferation of cells with clear to bubbly to eosinophilic cytoplasm and moderate nuclear atypia, proliferating fibroblasts, and necrosis, suggesting a clear cell carcinoma (possibly metastatic renal cell carcinoma). Intranuclear inclusions compatible with cytomegalovirus were identified on high-power examination and confirmed by immunohistochemistry. In lung transplant patients, a cytomegalovirus infection may mimic malignancy both radiographically and on initial histopathologic examination.

Tacrolimus-Induced Bradykinesia Secondary to Phenoconversion in an Elderly Post-Bilateral Lung Transplant Patient

2021 ◽  
Vol 36 (1) ◽  
pp. 34-41
Author(s):  
Lia Argevani ◽  
Michael J. Schuh ◽  
Sheena Crosby
Keyword(s):  
Adverse Effects ◽  
Drug Combination ◽  
Lung Transplant ◽  
Transplant Patient ◽  
Mortality And Morbidity ◽  
Risk Of Falls ◽  
Bilateral Lung ◽  
Morbidity Risk

Objective: To report pharmacogenomics post-related bradykinesia secondary to phenoconversion in an elderly post-bilateral lung transplant patient. Summary: The patient was a 68-year-old double lung transplant patient taking the immunosuppressant and CYP3A4/5 substrate tacrolimus concomitantly with 2 CYP3A4/5 inhibitor medications, fluconazole and diltiazem. This drug combination post-dosing resulted in debilitating bradykinesia 1-2 hours after dosing, increasing the risk of falls and possible increased mortality and morbidity risk. Conclusion: Taking tacrolimus in combination with CYP3A4/5 inhibitors may increase neurologic adverse effects resulting in increased fall and associated increased mortality and morbidity risk.

scholarly journals Aggressive Behaviour of Merkel Cell Carcinoma in a Kidney Transplant Patient Receiving Tacrolimus Treatment – Is There an Alternative in Immune Checkpoint Inhibitor Treatment?

2020 ◽  
pp. 1-4
Author(s):  
Giuseppina Gallucci ◽  
Anna Maria Bochicchio ◽  
Giuseppina Gallucci ◽  
Luigi Cagiano ◽  
Michele Grieco ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Merkel Cell Carcinoma ◽  
Immune Checkpoint ◽  
Aggressive Behaviour ◽  
Transplant Patient ◽  
Immune Checkpoint Inhibitor ◽  
Checkpoint Inhibitor ◽  
Kidney Transplant Patient ◽  
Merkel Cell ◽  
Transplant Patients

Background: Merkel cell carcinoma (MCC) is a rare skin neoplasm first described by Toker in 1972. The tumor usually presents in the sixth to seventh decade of life as a solitary reddish-brown to violaceous subcutaneous nodule on the head, neck, or the extremities. It is seen at an earlier age only in immunocompromised patients like transplant patients in immunosuppressive therapy. Thus, cancer has now become the second cause of death among transplant patients. The tumor growth is rapid in MCC patients, and for metastatic disease, no substantial benefit is obtained by chemotherapy. A new drug has recently become available, an immune checkpoint inhibitor (CPI), avelumab, that is able to delay disease progression significantly. However, there are no current guidelines for the use of immune checkpoint inhibitors in transplant patients. Case Presentation: We describe the case of a 55-year-old kidney transplant patient on immunosuppressive therapy with tacrolimus with an early occurrence of a Merkel cell carcinoma whose aggressive behaviour could not be hampered by Avelumab, due to fear of allograft rejection. Conclusion: CPI therapy is potentially lifesaving in advanced MCC. Further studies are urgently needed to test its benefit in this rapidly expanding field of post-transplant malignancies where there are only a few and less effective therapeutic options.

Cutaneous squamous cell carcinoma in two pediatric lung transplant patients on prolonged voriconazole treatment

2014 ◽  
Vol 18 (6) ◽  
pp. E200-E207 ◽  
Author(s):  
Jackson Y. Wong ◽  
Paul Kuzel ◽  
John Mullen ◽  
Dale Lien ◽  
Muhammad Mahmood ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Lung Transplant ◽  
Cutaneous Squamous Cell Carcinoma ◽  
Transplant Patients

scholarly journals New-onset asthma in a bilateral lung transplant patient

2019 ◽  
Vol 12 (11) ◽  
pp. e231654
Author(s):  
Daniel Benjamin Fyenbo ◽  
Kristine Bruun Degn ◽  
Johannes Martin Schmid ◽  
Elisabeth Bendstrup
Keyword(s):  
Lung Transplant ◽  
Inhaled Corticosteroids ◽  
Challenge Test ◽  
Bilateral Lung Transplantation ◽  
Beta Agonists ◽  
First Case ◽  
Bilateral Lung ◽  
Long Acting ◽  
Severe Airway Obstruction ◽  
New Onset

We present a case of new-onset asthma in a 35-year-old man who had undergone bilateral lung transplantation 11 years before due to idiopathic bronchiectasis and pulmonary hypertension. He presented with recurrent episodes of breathlessness, wheezing and coughing. Spirometry demonstrated severe airway obstruction. After treatment with systemic and inhaled corticosteroids and long-acting bronchodilators as well as short-acting beta-agonists as needed, his symptoms resolved and his spirometry normalised. A bronchial mannitol challenge test showed significant airway hyperresponsiveness and is thus consistent for a diagnosis of asthma. To our best knowledge, this is the first case of late new-onset asthma in a lung transplant recipient.

Evaluation of interleukin-6 and interleukin-10 in lung transplant patients with human cytomegalovirus infection

2009 ◽  
Vol 23 (5) ◽  
pp. 687-691 ◽  
Author(s):  
Konstantin Zedtwitz-Liebenstein ◽  
Peter Jaksch ◽  
Heinz Burgmann ◽  
Helmut Friehs ◽  
Roland Hofbauer ◽  
...  
Keyword(s):  
Human Cytomegalovirus ◽  
Interleukin 6 ◽  
Cytomegalovirus Infection ◽  
Lung Transplant ◽  
Interleukin 10 ◽  
Transplant Patients ◽  
Human Cytomegalovirus Infection

Impact of Cytomegalovirus Infection in Lung Transplant Patients Under Universal Prophylaxis: Single-Center Experience in Brazil

2010 ◽  
Vol 42 (2) ◽  
pp. 525-530 ◽  
Author(s):  
D.D.G. Bugano ◽  
S.V. Campos ◽  
J.E. Afonso ◽  
M.L. Caramori ◽  
R.H.O.B. Teixeira ◽  
...  
Keyword(s):  
Cytomegalovirus Infection ◽  
Lung Transplant ◽  
Single Center ◽  
Transplant Patients ◽  
Single Center Experience

First known case of successful pressure ulcer treatment in a lung transplant patient with post-COVID-19 pneumonia

2021 ◽  
Vol 30 (8) ◽  
pp. 594-597
Author(s):  
Yilan Tong ◽  
Sijiong Yu ◽  
Kaijun Guo ◽  
Xiangsheng Wang ◽  
Yang Wu ◽  
...  
Keyword(s):  
Lung Transplant ◽  
Transplant Patient ◽  
Myocutaneous Flap ◽  
Clinical Manifestations ◽  
Gluteus Maximus ◽  
Wound Therapy ◽  
Skin Tension ◽  
Transplant Patients ◽  
Relief System ◽  
Ulcer Treatment

Given the current COVID-19 crisis, multiple clinical manifestations and related complications of COVID-19 disease, especially in lung transplant patients following post-COVID-19 pneumonia, are a major challenge. Herein, we report the therapeutic course of the first reported case of sacrococcyx pressure ulcers (PU) in a 65-year-old male COVID-19 patient who underwent lung transplantation and developed a PU following surgery. We used a combination of regulated negative pressure-assisted wound therapy system (RNPT, six treatment courses, five days per treatment course), a skin tension-relief system (an intraoperative aid in minimising wounds caused by sacrococcygeal PUs) and a gluteus maximus myocutaneous flap to repair sacrococcygeal wounds. This successfully treated case provides a reference point for the treatment of similar cases.

Sign in / Sign up

Export Citation Format

Share Document