Anaesthetic management of a patient undergoing magnetic resonance imaging with suspected intracranial disease

Seizing patients with suspected intracranial disease are relatively common within the veterinary profession. Veterinary nurses will be familiar with some of the most common challenges these patients present while hospitalised, however to determine the cause and severity of disease, general anaesthesia is often required. This article will discuss some of the specific considerations during the peri-anaesthetic period of a seizing patient undergoing magnetic resonance imaging, including recommendations for future practice.

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Faculty Opinions recommendation of Exposure to surgery under general anaesthesia and brain magnetic resonance imaging changes in older adults.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.736722305.793567819 ◽

2019 ◽

Author(s):

Roderic Eckenhoff

Keyword(s):

Magnetic Resonance Imaging ◽

Older Adults ◽

Magnetic Resonance ◽

General Anaesthesia ◽

Brain Magnetic Resonance Imaging ◽

Resonance Imaging

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A source of artefact during general anaesthesia for magnetic resonance imaging

Anaesthesia ◽

10.1111/j.1365-2044.1993.tb07152.x ◽

1993 ◽

Vol 48 (7) ◽

pp. 643-643 ◽

Cited By ~ 3

Author(s):

S. Crofts ◽

A. Campbell

Keyword(s):

Magnetic Resonance Imaging ◽

Magnetic Resonance ◽

General Anaesthesia ◽

Resonance Imaging

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Neuroplasticity induced by general anaesthesia: study protocol for a randomised cross-over clinical trial exploring the effects of sevoflurane and propofol on the brain – A 3-T magnetic resonance imaging study of healthy volunteers

Trials ◽

10.1186/s13063-020-04468-y ◽

2020 ◽

Vol 21 (1) ◽

Author(s):

Signe Sloth Madsen ◽

Kirsten Møller ◽

Karsten Skovgaard Olsen ◽

Mark Bitsch Vestergaard ◽

Ulrich Lindberg ◽

...

Keyword(s):

Magnetic Resonance Imaging ◽

Clinical Trial ◽

Cognitive Function ◽

Magnetic Resonance ◽

Healthy Volunteers ◽

General Anaesthesia ◽

Well Being ◽

Resonance Imaging ◽

Link Type ◽

The Brain

Abstract Background Although used extensively worldwide, the effects of general anaesthesia on the human brain remain largely elusive. Moreover, general anaesthesia may contribute to serious conditions or adverse events such as postoperative cognitive dysfunction and delirium. To understand the basic mechanisms of general anaesthesia, this project aims to study and compare possible de novo neuroplastic changes induced by two commonly used types of general anaesthesia, i.e. inhalation anaesthesia by sevoflurane and intravenously administered anaesthesia by propofol. In addition, we wish to to explore possible associations between neuroplastic changes, neuropsychological adverse effects and subjective changes in fatigue and well-being. Methods This is a randomised, participant- and assessor-blinded, cross-over clinical trial. Thirty healthy volunteers (male:female ratio 1:1) will be randomised to general anaesthesia by either sevoflurane or propofol. Multimodal magnetic resonance imaging (MRI) of the brain will be performed before and after general anaesthesia and repeated after 1 and 8 days. Each magnetic resonance imaging session will be accompanied by cognitive testing and questionnaires on fatigue and well-being. After a wash-out period of 4 weeks, the volunteers will receive the other type of anaesthetic (sevoflurane or propofol), followed by the same series of tests. Primary outcomes: changes in T1-weighted 3D anatomy and diffusion tensor imaging. Secondary outcomes: changes in resting-state functional magnetic resonance imaging, fatigue, well-being, cognitive function, correlations between magnetic resonance imaging findings and the clinical outcomes (questionnaires and cognitive function). Exploratory outcomes: changes in cerebral perfusion and oxygen metabolism, lactate, and response to visual stimuli. Discussion To the best of our knowledge, this is the most extensive and advanced series of studies with head-to-head comparison of two widely used methods for general anaesthesia. Recruitment was initiated in September 2019. Trial registration Approved by the Research Ethics Committee in the Capital Region of Denmark, ref. H-18028925 (6 September 2018). EudraCT and Danish Medicines Agency: 2018-001252-35 (23 March 2018). www.clinicaltrials.gov, ID: NCT04125121. Retrospectively registered on 10 October 2019.

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