310 Method of Determining Unsteady Blood Flow Rate Condition in Ultrasonic-Measurement-Integrated Simulation

2007 ◽  
Vol 2006.19 (0) ◽  
pp. 70-71
Author(s):  
Takayuki YAMAGATA ◽  
Toshiyuki HAYASE
Keyword(s):  
Blood Flow ◽  
Flow Rate ◽  
Blood Flow Rate ◽  
Ultrasonic Measurement ◽  
Rate Condition ◽  
Integrated Simulation ◽  
Unsteady Blood Flow

2B47 Consideration on the evaluation function of blood flow rate estimation in ultrasonic-measurement-integrated simulation

2014 ◽  
Vol 2014.26 (0) ◽  
pp. 337-338
Author(s):  
Hiroko KADOWAKI ◽  
Toshiyuki HAYASE ◽  
Kenichi FUNAMOTO ◽  
Shusaku SONE ◽  
Takao JIBIKI ◽  
...  
Keyword(s):  
Blood Flow ◽  
Flow Rate ◽  
Blood Flow Rate ◽  
Ultrasonic Measurement ◽  
Evaluation Function ◽  
Integrated Simulation ◽  
Rate Estimation

Abstract 295: Importance of the Rate of Platelet Activation by Thrombin for Regulating the Size of Thrombi Formed Under Low Blood Flow Velocity Conditions

2016 ◽  
Vol 119 (suppl_1) ◽  
Author(s):  
Shinichi Goto ◽  
Kengo Ayabe ◽  
Youth Kawamura ◽  
Noriko Tamura ◽  
Shinya Goto
Keyword(s):  
Blood Flow ◽  
Flow Velocity ◽  
Platelet Activation ◽  
Flow Rate ◽  
Blood Flow Rate ◽  
Low Flow ◽  
Coagulation Cascade ◽  
Computer Simulation Model ◽  
Rate Condition ◽  
Low Flow Rate

Background: Platelets, coagulation cascade including thrombin and fibrin, and fibrinolysis by plasmin along with blood flow are known to play regulatory roles in thrombogenesis. However, quantitative and interactive contribution of these factors are not fully understood. Method: We developed a computer simulation model of thrombi at sites of vessel injury by implementing quantitative parameters of blood flow, platelet, coagulation cascade and fibrinolysis. In this model, we defined thrombi as the area where the amount of activated platelet become 80% or more of the global platelet count of 3.0х10 5 /mm 3 upon vessel damage We have measured the 3-dimensional size of thrombi as defined in various conditions with various parameters of flow velocity, rate of platelet activation by thrombin, rate of thrombin production on the surface of activated platelets, rate of fibrinolysis and rate of plasmin production. Results: Rate of platelet activation by thrombin had the largest influence on the size of thrombi under low flow rate condition of 0.5 (cm/sec) (Fig1 A). When blood flow rate increased to 2.0 (cm/sec), the absolute importance of this parameter decreased (Fig1 B). Conclusion: Our results show that the rate of platelet activation by thrombin, which are signaled with PAR-1 receptor in human, has a marked effect on the size of thrombi in low flow rate condition suggesting the benefit of blocking this receptor in low blood flow condition such as venous thrombosis.

Numerical Experiment for Ultrasonic-Measurement-Integrated Simulation of Three-Dimensional Unsteady Blood Flow

2008 ◽  
Vol 36 (8) ◽  
pp. 1383-1397 ◽  
Author(s):  
Kenichi Funamoto ◽  
Toshiyuki Hayase ◽  
Yoshifumi Saijo ◽  
Tomoyuki Yambe
Keyword(s):  
Blood Flow ◽  
Numerical Experiment ◽  
Three Dimensional ◽  
Ultrasonic Measurement ◽  
Integrated Simulation ◽  
Unsteady Blood Flow

The Effect of Furosemide on the Intrarenal Blood Flow Distribution in the Dog

1972 ◽  
Vol 50 (8) ◽  
pp. 774-783 ◽  
Author(s):  
Serge Carrière ◽  
Michel Desrosiers ◽  
Jacques Friborg ◽  
Michèle Gagnan Brunette
Keyword(s):  
Blood Flow ◽  
Flow Rate ◽  
Urine Volume ◽  
Flow Distribution ◽  
Blood Flow Rate ◽  
Initial Distribution ◽  
Blood Flow Distribution ◽  
Intrarenal Blood Flow ◽  
Femoral Blood ◽  
Furosemide Administration

Furosemide (40 μg/min) was perfused directly into the renal artery of dogs in whom the femoral blood pressure was reduced (80 mm Hg) by aortic clamping above the renal arteries. This maneuver, which does not influence the intrarenal blood flow distribution, produced significant decreases of the urine volume, natriuresis, Ccreat, and CPAH, and prevented the marked diuresis normally produced by furosemide. Therefore the chances that systemic physiological changes occurred, secondary to large fluid movements, were minimized. In those conditions, however, furosemide produced a significant increase of the urine output and sodium excretion in the experimental kidney whereas Ccreat and CPAH were not affected. The outer cortical blood flow rate (ml/100 g-min) was modified neither by aortic constriction (562 ± 68 versus 569 ± 83) nor by the subsequent administration of furosemide (424 ± 70). The blood flow rate of the outer medulla in these three conditions remained unchanged (147 ± 52 versus 171 ± 44 versus 159 ± 54). The initial distribution of the radioactivity in each compartment remained comparable in the three conditions. In parallel with the results from the krypton-85 disappearance curves, the autoradiograms, silicone rubber casts, and EPAH did not suggest any change in the renal blood flow distribution secondary to furosemide administration.

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