Abstract 295: Importance of the Rate of Platelet Activation by Thrombin for Regulating the Size of Thrombi Formed Under Low Blood Flow Velocity Conditions

2016 ◽  
Vol 119 (suppl_1) ◽  
Author(s):  
Shinichi Goto ◽  
Kengo Ayabe ◽  
Youth Kawamura ◽  
Noriko Tamura ◽  
Shinya Goto
Keyword(s):  
Blood Flow ◽  
Flow Velocity ◽  
Platelet Activation ◽  
Flow Rate ◽  
Blood Flow Rate ◽  
Low Flow ◽  
Coagulation Cascade ◽  
Computer Simulation Model ◽  
Rate Condition ◽  
Low Flow Rate

Background: Platelets, coagulation cascade including thrombin and fibrin, and fibrinolysis by plasmin along with blood flow are known to play regulatory roles in thrombogenesis. However, quantitative and interactive contribution of these factors are not fully understood. Method: We developed a computer simulation model of thrombi at sites of vessel injury by implementing quantitative parameters of blood flow, platelet, coagulation cascade and fibrinolysis. In this model, we defined thrombi as the area where the amount of activated platelet become 80% or more of the global platelet count of 3.0х10 5 /mm 3 upon vessel damage We have measured the 3-dimensional size of thrombi as defined in various conditions with various parameters of flow velocity, rate of platelet activation by thrombin, rate of thrombin production on the surface of activated platelets, rate of fibrinolysis and rate of plasmin production. Results: Rate of platelet activation by thrombin had the largest influence on the size of thrombi under low flow rate condition of 0.5 (cm/sec) (Fig1 A). When blood flow rate increased to 2.0 (cm/sec), the absolute importance of this parameter decreased (Fig1 B). Conclusion: Our results show that the rate of platelet activation by thrombin, which are signaled with PAR-1 receptor in human, has a marked effect on the size of thrombi in low flow rate condition suggesting the benefit of blocking this receptor in low blood flow condition such as venous thrombosis.

scholarly journals Pore-Scale Simulations of Particles Migration and Deposition in Porous Media Using LBM-DEM Coupling Method

Processes ◽  
2021 ◽  
Vol 9 (3) ◽  
pp. 465
Author(s):  
Yanjie Zhou ◽  
Liping Chen ◽  
Yanfeng Gong ◽  
Shilin Wang
Keyword(s):  
Porous Media ◽  
Critical Velocity ◽  
Flow Rate ◽  
Shear Force ◽  
Particle Deposition ◽  
Moving Boundary ◽  
Low Flow ◽  
Rate Condition ◽  
Groundwater Source ◽  
Low Flow Rate

This paper studies the migration and deposition of suspended particles in porous media. This problem results from the fact that during the operation of a groundwater source heat pump, the recharging process will contribute to the impairment of soil permeability. A coupling lattice Boltzmann method, discrete element method and immersed moving boundary method were used to investigate the migration of particles in porous media. The DKT (Drifting, Kissing, Tumbling) phenomena were employed to validate our program. The coupled effects of concentration, flow rate and pH on the clogging mechanism of the porous media were analyzed. Results show that, due to the repulsive barrier between the particles and porous media, there is a critical velocity. At a low flow rate, the deposition ratio increases with the increase in velocity. Beyond the critical velocity, the deposition ratio decreases when the velocity increases due to higher shear force. Permeability impairment increases with the increase in concentration, especially in the low flow rate condition. Changes in pH mainly affect the repulsive barrier. For a low flow rate, the decrease in repulsive barrier greatly promotes the deposition of particles. Under the condition of favorable deposition, the increase in flow rate reduces the deposition phenomenon. Under the condition of unfavorable deposition, the lower flow rate condition has a lower deposition ratio. The process of particle deposition and the dynamic motion after deposition were observed such as particles gliding over the surface. Accumulated particles in the downstream form bridges and hinder fluid flow. At a high flow rate, strong shear force is more capable of destroying bridges and recovering permeability. Adsorbed particles glide on the surface of the grain and deposit in the downstream. This paper aims to help understanding of the micro-events of particle deposition and the clogging process.

scholarly journals Blood Flow Velocity in the Pial Arteries of Cats, with Particular Reference to the Vessel Diameter

1984 ◽  
Vol 4 (1) ◽  
pp. 110-114 ◽  
Author(s):  
Masahiro Kobari ◽  
Fumio Gotoh ◽  
Yasuo Fukuuchi ◽  
Kortaro Tanaka ◽  
Norihiro Suzuki ◽  
...  
Keyword(s):  
Blood Flow ◽  
Flow Velocity ◽  
Flow Rate ◽  
Blood Flow Velocity ◽  
Blood Flow Rate ◽  
Video Camera ◽  
Vessel Diameter ◽  
Pial Arteries ◽  
Cross Sectional ◽  
Pial Artery

The blood flow velocity and diameter of feline pial arteries, ranging in diameter from 20 to 200 μm, were measured simultaneously using a newly developed video camera method under steady-state conditions for all other parameters. There was a linear relationship between blood flow velocity and pial artery diameter ( y = 0.340 x + 0.309), the correlation coefficient being 0.785 (p < 0.001). The average values for blood flow velocity in pial arteries <50 μm, ≧50 but <100 μm, ≧100 but <150 μm, and ≧150 μm in diameter were 12.9 ± 1.3, 24.6 ± 3.4, 42.1 ± 4.7, and 59.9 ± 5.3 mm/s, respectively. Blood flow rate was calculated as a product of the cross-sectional area and the flow velocity. The blood flow rate increased exponentially as the pial artery diameter increased ( y = 2.71 × 10−4 x2.98). The average values for blood flow rate in pial arteries <50 μm, ≧50 but <100 μm, ≧100 but <150 μm, and ≧150 μm in diameter were 12.8 ± 1.5, 122.1 ± 24.8, 510.2 ± 74.8, and 1524.2 ± 174.4 10−3 mm3/s, respectively. Hemorheological parameters such as the wall shear rate and Reynolds' number were also calculated. The data obtained provide a useful basis for further investigations in the field of cerebral circulation.

Recirculation Reassessed: The Impact of Blood Flow Rate and the Low-Flow Method Reevaluated

1994 ◽  
Vol 23 (6) ◽  
pp. 846-848 ◽  
Author(s):  
Richard A. Sherman ◽  
James J. Matera ◽  
Laura Novik ◽  
Ronald P. Cody
Keyword(s):  
Blood Flow ◽  
Flow Rate ◽  
Blood Flow Rate ◽  
Low Flow ◽  
Flow Method ◽  
The Impact

D12 Flow Fields of Semi-Open Axial Fan at Low Flow Rate Condition

2008 ◽  
Vol 2008 (0) ◽  
pp. 151-152
Author(s):  
Sho KUMAMOTO ◽  
Norimasa SHIOMI ◽  
Yoichi KINOUE ◽  
Kenji KANEKO ◽  
Toshiaki SETOGUCHI
Keyword(s):  
Flow Rate ◽  
Flow Fields ◽  
Low Flow ◽  
Axial Fan ◽  
Rate Condition ◽  
Low Flow Rate

scholarly journals Spheres in the vicinity of a bifurcation: elucidating the Zweifach–Fung effect

2011 ◽  
Vol 674 ◽  
pp. 359-388 ◽  
Author(s):  
V. DOYEUX ◽  
T. PODGORSKI ◽  
S. PEPONAS ◽  
M. ISMAIL ◽  
G. COUPIER
Keyword(s):  
Blood Flow ◽  
Flow Rate ◽  
Volume Fraction ◽  
Initial Distribution ◽  
High Flow ◽  
High Flow Rate ◽  
Low Flow ◽  
Two Dimensional ◽  
Flow Rates ◽  
Low Flow Rate

The problem of the splitting of a suspension in bifurcating channels divided into two branches of non-equal flow rates is addressed. As has long been observed, in particular in blood flow studies, the volume fraction of particles generally increases in the high-flow-rate branch and decreases in the low-flow-rate branch. In the literature, this phenomenon is sometimes interpreted as the result of some attraction of the particles towards this high-flow-rate branch. In this paper, we focus on the existence of such an attraction through microfluidic experiments and two-dimensional simulations and show clearly that such an attraction does not occur but is, on the contrary, directed towards the low-flow-rate branch. Arguments for this attraction are given and a discussion on the sometimes misleading arguments found in the literature is given. Finally, the enrichment of particles in the high-flow-rate branch is shown to be mainly a consequence of the initial distribution in the inlet branch, which shows necessarily some depletion near the walls.

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