801 Development of Microcapsules for Shock Wave Drug Delivery Systems : Capsule Structure and Driving Force(2)

2006 ◽  
Vol 2006 (0) ◽  
pp. _801-1_-_801-4_
Author(s):  
Yuuta KUBOMOTO ◽  
Masaaki TAMAGAWA ◽  
Shirou SUETUGU
Keyword(s):  
Shock Wave ◽  
Drug Delivery ◽  
Driving Force ◽  
Drug Delivery Systems ◽  
Delivery Systems

Development of Microcapsules Including a Gas Bubble for Shock Wave Based Drug Delivery

2008 ◽  
Author(s):  
Masaaki Tamagawa ◽  
Norikazu Ishimatsu
Keyword(s):  
Mechanical Properties ◽  
Shock Wave ◽  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Gas Bubble

This paper describes the trial of making microcapsules including a bubble for shock wave drug delivery systems, evaluation of their mechanical properties and development of new driving mechanics of the microcapsules.

Analysis of a Bubble Deformation Process in a Microcapsule for Developing Drug Delivery Systems Using Underwater Shock Waves

2010 ◽  
Author(s):  
Masaaki Tamagawa
Keyword(s):  
Shock Wave ◽  
Drug Delivery ◽  
Shock Waves ◽  
Transport Process ◽  
Deformation Process ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Cytokine Concentration ◽  
Bubble Deformation ◽  
Underwater Shock

This paper describes development of microcapsule using underwater shock waves, especially (1) the trial of making smaller microcapsules including a bubble for shock wave drug delivery systems, and analysis of a bubble deformation process to have higher efficiency of disintegration by shock wave, and (2) the effects of gradient of cytokine concentration on neutrophile motion in liquid by observing the concentration transport process with adding cytokine for developing drug delivery systems.

Fundamental Investigations of Driving Force of Microcapsule for Drug Delivery Systems Using the Principle of Neutrophile’s Chemotaxis

2007 ◽  
Author(s):  
Masaaki Tamagawa
Keyword(s):  
Drug Delivery ◽  
Driving Force ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Cytokine Concentration ◽  
Marangoni Effects

This paper describes the effects of gradient of cytokine concentration on chemotaxis of neutrophile by observing the motion in liquid with adding cytokine concentration. The aim of this investigation is to distinguish the driving force by Marangoni effects from amebic motion.

Prototype of Microcapsule for Shock Wave Drug Delivery Systems and Its Design

2007 ◽  
Author(s):  
Masaaki Tamagawa
Keyword(s):  
Mechanical Properties ◽  
Shock Wave ◽  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems

This paper describes the trial of making microcapsules including a bubble for shock wave drug delivery systems, evaluation of their mechanical properties and development of new driving mechanics of the microcapsules.

Prototype of Microcapsule Including a Gas Bubble for Developing Shock Wave Drug Delivery Systems

2005 ◽  
Author(s):  
Masaaki Tamagawa ◽  
Ichiro Yamanoi
Keyword(s):  
Mechanical Properties ◽  
Shock Wave ◽  
Drug Delivery ◽  
Biomedical Engineering ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
The Body ◽  
Gas Bubble ◽  
Nano Technology ◽  
System A

This paper describes the trial of making microcapsules including a bubble for shock wave drug delivery systems and evaluation of their mechanical properties. We have proposed drug delivery systems (DDS) using shock waves in order to apply micro/nano technology in the fields of biomedical engineering. In this system, a microcapsule including a gas bubble is flown in the blood vessel, and finally broken by shock induced microjet, then drug is reached to the affected part in the body as same as traditional DDS. In this paper, the mechanism for deformation and disintegration of capsules in our previous works is reviewed, and the trials of making special microcapsules are discussed. To determine Young’s modulus of capsule membrane mentioned above, the membrane is deformed by the aspiration device and the deformation is compared with computational result by FEM.

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