Prototype of Microcapsule for Shock Wave Drug Delivery Systems and Its Design

2007 ◽  
Author(s):  
Masaaki Tamagawa
Keyword(s):  
Mechanical Properties ◽  
Shock Wave ◽  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems

This paper describes the trial of making microcapsules including a bubble for shock wave drug delivery systems, evaluation of their mechanical properties and development of new driving mechanics of the microcapsules.

Development of Microcapsules Including a Gas Bubble for Shock Wave Based Drug Delivery

2008 ◽  
Author(s):  
Masaaki Tamagawa ◽  
Norikazu Ishimatsu
Keyword(s):  
Mechanical Properties ◽  
Shock Wave ◽  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Gas Bubble

This paper describes the trial of making microcapsules including a bubble for shock wave drug delivery systems, evaluation of their mechanical properties and development of new driving mechanics of the microcapsules.

Prototype of Microcapsule Including a Gas Bubble for Developing Shock Wave Drug Delivery Systems

2005 ◽  
Author(s):  
Masaaki Tamagawa ◽  
Ichiro Yamanoi
Keyword(s):  
Mechanical Properties ◽  
Shock Wave ◽  
Drug Delivery ◽  
Biomedical Engineering ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
The Body ◽  
Gas Bubble ◽  
Nano Technology ◽  
System A

This paper describes the trial of making microcapsules including a bubble for shock wave drug delivery systems and evaluation of their mechanical properties. We have proposed drug delivery systems (DDS) using shock waves in order to apply micro/nano technology in the fields of biomedical engineering. In this system, a microcapsule including a gas bubble is flown in the blood vessel, and finally broken by shock induced microjet, then drug is reached to the affected part in the body as same as traditional DDS. In this paper, the mechanism for deformation and disintegration of capsules in our previous works is reviewed, and the trials of making special microcapsules are discussed. To determine Young’s modulus of capsule membrane mentioned above, the membrane is deformed by the aspiration device and the deformation is compared with computational result by FEM.

scholarly journals Thiolation of Biopolymers for Developing Drug Delivery Systems with Enhanced Mechanical and Mucoadhesive Properties: A Review

Polymers ◽  
2020 ◽  
Vol 12 (8) ◽  
pp. 1803
Author(s):  
Vivek Puri ◽  
Ameya Sharma ◽  
Pradeep Kumar ◽  
Inderbir Singh
Keyword(s):  
Mechanical Properties ◽  
Drug Delivery ◽  
Efficient Method ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Review Article ◽  
Present Review ◽  
Tabular Form ◽  
Thiolated Polymers ◽  
Drug Delivery Applications

Biopolymers are extensively used for developing drug delivery systems as they are easily available, economical, readily modified, nontoxic, biodegradable and biocompatible. Thiolation is a well reported approach for enhancing mucoadhesive and mechanical properties of polymers. In the present review article, for the modification of biopolymers different thiolation methods and evaluation/characterization techniques have been discussed in detail. Reported literature on thiolated biopolymers with enhanced mechanical and mucoadhesive properties has been presented conspicuously in text as well as in tabular form. Patents filed by researchers on thiolated polymers have also been presented. In conclusion, thiolation is an easily reproducible and efficient method for customization of mucoadhesive and mechanical properties of biopolymers for drug delivery applications.

Analysis of a Bubble Deformation Process in a Microcapsule for Developing Drug Delivery Systems Using Underwater Shock Waves

2010 ◽  
Author(s):  
Masaaki Tamagawa
Keyword(s):  
Shock Wave ◽  
Drug Delivery ◽  
Shock Waves ◽  
Transport Process ◽  
Deformation Process ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Cytokine Concentration ◽  
Bubble Deformation ◽  
Underwater Shock

This paper describes development of microcapsule using underwater shock waves, especially (1) the trial of making smaller microcapsules including a bubble for shock wave drug delivery systems, and analysis of a bubble deformation process to have higher efficiency of disintegration by shock wave, and (2) the effects of gradient of cytokine concentration on neutrophile motion in liquid by observing the concentration transport process with adding cytokine for developing drug delivery systems.

scholarly journals Influence of process route on the mechanical properties of polymer based intravaginal drug delivery systems

2017 ◽  
Author(s):  
K. Eggenreich ◽  
S. Schrank ◽  
G. Koscher ◽  
K. Nickisch ◽  
E. Roblegg ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Process Route
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