scholarly journals Posterior reversible encephalopathy syndrome following sepsis in a Crohn’s disease patient: A case report

2016 ◽  
Vol 4 (4) ◽  
pp. 103 ◽  
Author(s):  
Ioannis Papaconstantinou ◽  
Dionysios S Mantzos ◽  
Eirini Pantiora ◽  
Marios K Tasoulis ◽  
Sofia Vassilopoulou ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Case Report ◽  
Crohn's Disease ◽  
Posterior Reversible Encephalopathy Syndrome ◽  
Disease Patient ◽  
Posterior Reversible Encephalopathy ◽  
Reversible Encephalopathy

scholarly journals Posterior Reversible Encephalopathy Syndrome following Ustekinumab Induction for Crohn’s Disease

2018 ◽  
Vol 12 (2) ◽  
pp. 521-527 ◽  
Author(s):  
Avantika Mishra ◽  
Darren N. Seril
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Posterior Reversible Encephalopathy Syndrome ◽  
Human Monoclonal Antibody ◽  
Interleukin 12 ◽  
Cytokine Signaling ◽  
Acute Encephalopathy ◽  
Posterior Reversible Encephalopathy ◽  
Inflammatory Bowel ◽  
Reversible Encephalopathy

Biological agents are frequently used in the management of inflammatory bowel disease, and it is important to understand the potential adverse effects of these therapies. Ustekinumab is a human monoclonal antibody that interferes with interleukin-12 and -23 cytokine signaling and is approved for the treatment of moderate to severe Crohn’s disease. We report 2 cases of neurological adverse events, one of which is consistent with posterior reversible encephalopathy syndrome (PRES), in the setting of ustekinumab therapy for Crohn’s disease. The first patient had a seizure and classic neuroimaging features of PRES following induction with ustekinumab. The second patient presented with acute encephalopathy and atypical imaging findings concerning for PRES after ustekinumab induction. Both patients recovered fully following cessation of ustekinumab therapy. PRES associated with ustekinumab is uncommon, but must be a consideration in Crohn’s disease patients receiving this therapy who present with focal neurological symptoms or change in mentation.

scholarly journals Neurological manifestations related to Crohn’s disease: a boon for the workforce

2017 ◽  
Vol 7 (4) ◽  
pp. 291-297 ◽  
Author(s):  
Reza Nemati ◽  
Somayeh Mehdizadeh ◽  
Hooman Salimipour ◽  
Ehsan Yaghoubi ◽  
Zeinab Alipour ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Optic Neuropathy ◽  
Posterior Reversible Encephalopathy Syndrome ◽  
Chronic Inflammatory Demyelinating Polyneuropathy ◽  
Ischemic Optic Neuropathy ◽  
Neurological Manifestations ◽  
Posterior Reversible Encephalopathy ◽  
Inflammatory Demyelinating Polyneuropathy ◽  
Reversible Encephalopathy

Abstract The neurological manifestations of Crohn’s disease and its prevalence are not well known. Here, we report five patients of confirmed Crohn’s disease with different neurological presentations. The neurological presentations include anterior ischemic optic neuropathy, myelopathy, posterior reversible encephalopathy syndrome, chronic inflammatory demyelinating polyneuropathy, and chronic axonal sensory and motor polyneuropathy. These manifestations should be kept in mind in the assessment of Crohn’s disease.

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