A Pediatric Case Definition for Myalgic Encephalomyelitis and Chronic Fatigue Syndrome

2006 ◽  
Vol 13 (2-3) ◽  
pp. 1-44 ◽  
Author(s):  
Leonard A. Jason ◽  
Karen Jordan ◽  
Teruhisa Miike ◽  
David S. Bell ◽  
Charles Lapp ◽  
...  
Keyword(s):  
Chronic Fatigue Syndrome ◽  
Chronic Fatigue ◽  
Case Definition ◽  
Myalgic Encephalomyelitis ◽  
Pediatric Case ◽  
Fatigue Syndrome

scholarly journals Chronic fatigue syndrome and myalgic encephalomyelitis: towards an empirical case definition

2015 ◽  
Vol 3 (1) ◽  
pp. 82-93 ◽  
Author(s):  
Leonard A. Jason ◽  
Bobby Kot ◽  
Madison Sunnquist ◽  
Abigail Brown ◽  
Meredyth Evans ◽  
...  
Keyword(s):  
Chronic Fatigue Syndrome ◽  
Chronic Fatigue ◽  
Case Definition ◽  
Myalgic Encephalomyelitis ◽  
Fatigue Syndrome

scholarly journals A Case Definition for Children with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

2008 ◽  
Vol 1 ◽  
pp. CMPed.S978 ◽  
Author(s):  
Leonard A. Jason ◽  
Nicole Porter ◽  
Elizabeth Shelleby ◽  
David S. Bell ◽  
Charles W. Lapp ◽  
...  
Keyword(s):  
Chronic Fatigue Syndrome ◽  
Children And Adolescents ◽  
Sensitivity And Specificity ◽  
International Association ◽  
Chronic Fatigue ◽  
Case Definition ◽  
Myalgic Encephalomyelitis ◽  
Fatigue Syndrome ◽  
Reliable Instrument

The case definition for chronic fatigue syndrome was developed for adults (Fukuda et al. 1994), and this case definition may not be appropriate for use with children and adolescents. The lack of application of a consistent pediatric definition for this illness and the lack of a reliable instrument to assess it might lead to studies which lack sensitivity and specificity. In this article, a case definition is presented that has been endorsed by the International Association of ME/CFS.

scholarly journals Review of case definitions for myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)

2020 ◽  
Vol 18 (1) ◽  
Author(s):  
Eun-Jin Lim ◽  
Chang-Gue Son
Keyword(s):  
Chronic Fatigue Syndrome ◽  
Orthostatic Intolerance ◽  
Chronic Fatigue ◽  
Case Definition ◽  
Myalgic Encephalomyelitis ◽  
Case Definitions ◽  
Fatigue Syndrome ◽  
Mesh Terms ◽  
Duration Of Illness ◽  
Primary Disorder

Abstract Background Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating disease with unknown causes. From the perspectives on the etiology and pathophysiology, ME/CFS has been labeled differently, which influenced changes in case definitions and terminologies. This review sought to feature aspects of the history, developments, and differential symptoms in the case definitions. Methods A search was conducted through PubMed published to February 2020 using the following search keywords: case definition AND chronic fatigue syndrome [MeSH Terms]. All reference lists of the included studies were checked. Of the included studies, the number of citations and the visibility in the literatures of the definitions were considered for comparisons of the criteria. Results Since the first 'ME' case definition was developed in 1986, 25 case definitions/diagnostic criteria were created based on three conceptual factors (etiology, pathophysiology, and exclusionary disorders). These factors can be categorized into four categories (ME, ME/CFS, CFS, and SEID) and broadly characterized according to primary disorder (ME-viral, CFS-unknown, ME/CFS-inflammatory, SEID-multisystemic), compulsory symptoms (ME and ME/CFS-neuroinflammatory, CFS and SEID-fatigue and/or malaise), and required conditions (ME-infective agent, ME/CFS, CFS, SEID-symptoms associated with fatigue, e.g., duration of illness). ME and ME/CFS widely cover all symptom categories, while CFS mainly covers neurologic and neurocognitive symptoms. Fatigue, cognitive impairment, PEM, sleep disorder, and orthostatic intolerance were the overlapping symptoms of the 4 categories, which were included as SEID criteria. Conclusions This study comprehensively described the journey of the development of case definitions and compared the symptom criteria. This review provides broader insights and explanations to understand the complexity of ME/CFS for clinicians and researchers.

scholarly journals Examining case definition criteria for chronic fatigue syndrome and myalgic encephalomyelitis

2013 ◽  
Vol 2 (1) ◽  
pp. 40-56 ◽  
Author(s):  
Leonard A. Jason ◽  
Madison Sunnquist ◽  
Abigail Brown ◽  
Meredyth Evans ◽  
Suzanne D. Vernon ◽  
...  
Keyword(s):  
Chronic Fatigue Syndrome ◽  
Chronic Fatigue ◽  
Case Definition ◽  
Myalgic Encephalomyelitis ◽  
Fatigue Syndrome

scholarly journals Clinical criteria versus a possible research case definition in chronic fatigue syndrome/myalgic encephalomyelitis

2017 ◽  
Vol 5 (2) ◽  
pp. 89-102 ◽  
Author(s):  
Leonard A. Jason ◽  
Stephanie McManimen ◽  
Madison Sunnquist ◽  
Julia L. Newton ◽  
Elin Bolle Strand
Keyword(s):  
Chronic Fatigue Syndrome ◽  
Chronic Fatigue ◽  
Case Definition ◽  
Myalgic Encephalomyelitis ◽  
Clinical Criteria ◽  
Fatigue Syndrome

scholarly journals Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): Major Impact on Lives of Both Patients and Family Members

Medicina ◽  
2021 ◽  
Vol 57 (1) ◽  
pp. 43
Author(s):  
Esme Brittain ◽  
Nina Muirhead ◽  
Andrew Y. Finlay ◽  
Jui Vyas
Keyword(s):  
Quality Of Life ◽  
Chronic Fatigue Syndrome ◽  
Physical Health ◽  
Family Members ◽  
Chronic Fatigue ◽  
Myalgic Encephalomyelitis ◽  
World Health ◽  
Life Questionnaire ◽  
Fatigue Syndrome

Background and objectives: To explore the impacts that Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) has on the patient and their family members using the WHOQOL-BREF (Abbreviated World Health Organisation Quality of Life questionnaire) and FROM-16 (Family Reported Outcome Measure-16) quality of life assessments. Materials and Methods: A quantitative research study using postal questionnaires was conducted. A total of 39 adult volunteers expressed an interest in participating in the study: 24 returned appropriately completed questionnaires. Patients with ME/CFS completed the WHOQOL-BREF and up to four of their family members completed the FROM-16 questionnaire. Results: ME/CFS negatively affects the quality of life of the patient (median scores WHOQOL-BREF: Physical health = 19, Psychological = 44, Social relationships = 37.5, Environment = 56, n = 24) and their family members’ quality of life (FROM-16: Emotional = 9.5, Personal and social = 11.5, Overall = 20.5, n = 42). There was a significant correlation between the patient’s reported quality of life scores and their family members’ mean FROM-16 total scores. Conclusions: This study identifies the major impact that having an adult family member with ME/CFS has on the lives of partners and of other family members. Quality of life of ME/CFS patients was reduced most by physical health compared to the other domains. Quality of life of family members was particularly impacted by worry, family activities, frustration and sadness. This highlights the importance of measuring the impact on the lives of family members using tools such as the FROM-16 in the ME/CFS clinical encounter and ensuring appropriate support is widely available to family members.

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