Clinical evidence in the phenomenon of Alien Abduction

Purpose: Starting from the classic definition of “alien abduction”, the present research, starting from the study published in 2020 on the proposed clinical classification of this particular phenomenon, is aimed at confirming the theoretical assumption of psychopathological origin. Methods: Clinical interview, based on narrative-anamnestic and documentary evidence and the basis of the Perrotta Human Emotions Model (PHEM) concerning their emotional and perceptual-reactive experience, and administration of the battery of psychometric tests published in international scientific journals by the author of this work: 1) Perrotta Integrative Clinical Interviews (PICI-2), to investigate functional and dysfunctional personality traits; 2) Perrotta Individual Sexual Matrix Questionnaire (PSM-Q), to investigate the individual sexual matrix; 3) Perrotta Affective Dependence Questionnaire (PAD-Q), to investigate the profiles of affective and relational dependence; 4) Perrotta Human Defense Mechanisms Questionnaire (PDM-Q), to investigate the defence mechanisms of the Ego. Results: Preliminary results from the interviews and the anamnestic form would suggest that the phenomenon of alien abductions has a greater tendency to occur in the female group, in the adult and mature group (and tends to diminish but not disappear with advancing age) and in the group geographically originating in central-northern Italy (due to lower religious influences but greater openness to the typical contents of ufological and mystery narratives). Moreover, the subsequent results would lead us to deduce with almost total certainty, concerning the selected sample, that the phenomenon of alien abductions has an absolute prevalence in the believing population concerning the existence of paranormal phenomena per se, even in the absence of objective and/or scientific evidence. It is a phenomenon that is almost completely linked (110/112, 98.2%) to a medium-low or not fully educated cultural level. Based on the PICI-2 it emerged that the primary emerging disorder is alternatively the delusional disorder, the dissociative disorder and the narcissistic disorder; followed, as secondary disorders, by the delusional disorder (if it is not considered as primary disorder), the schizoid disorder, the borderline disorder, the obsessive disorder and the psychopathic disorder. The analysis of functional traits also reported the marked dysfunctional tendency of the classes referring to self-control, sensitivity, Ego-Es comparison, emotionality, ego stability, security and relational functionality, confirming here too the marked dysfunctional tendency of the clinical population. According to the PSM-Q, almost 2/3 of the participants (73/112, 65.2%) present a dysfunctional tendency to sexual behaviour and a marked tendency to chronicle feelings of shame in avoidance behaviour or hyposexuality. Furthermore, 100% of the sample of the population surveyed report having suffered significant or serious psychological or physical abuse at a young age, or intra-parental relational imbalances, or in any case a sexual upbringing that was not open and lacking in free communication. According to the PDM-Q, 27.7% (31/112) are affected by affective dependency, with greater emphasis on types I (neurotic), VI (covert narcissist), V (borderline) and III (histrionic), in that order of descent. Finally, the PDM-Q reveals the widespread psychopathological tendency of the functional ego framework for the mechanisms of isolation, denial, regression, reactive formation, denial, projection, removal, withdrawal, instinct, repression and idealisation. Conclusion: This research confirms the psychopathological nature of the alien abduction phenomenon, which deserves to be treated using a psychotherapeutic approach (preferably cognitive-behavioural and/or strategic) and possibly also pharmacological in serious cases, depending on the symptoms manifested and the severity of the morbid condition.

CBT for Childhood Anxiety: Reviewing the State of Personalised Intervention Research

This article presents a mini-review of the state of personalised intervention research in the field of child and adolescent anxiety. We evaluated narrative, systematic and meta-analytic reviews of key research methodologies and how they relate to current approaches for personalising CBT, specifically. Preliminary evidence of predictors (severity of primary disorder, social anxiety disorder (SoAD), comorbid depression, parental psychopathology, parental involvement and duration of treatment), moderators (type of primary disorder) and mediators (self-talk, coping, problem-solving and comorbid symptoms) of CBT outcomes provides content for several personalised approaches to treatment. Finally, we present a novel conceptual model depicting the state of personalised intervention research in childhood anxiety and propose a research agenda for continued progress.

Auto Fluorescence Allows Us to Detect Early Signs of Oral Cancer and Much More

This paper introduces a novel approach, using autofluorescence, to objectively examine the oral cavity for inflammation and infection. Many systemic diseases are perpetuated by microorganisms that colonize in the oral environment. They enter the cardiovascular system by enzymatic processes that open the oral mucosa to allow their entry. A majority of the microbes are anaerobes and/or facultative anaerobes. When they enter the host, they metabolize blood. Their waste by products contains iron elements within a compound called porphyrin. Porphyrin will fluoresce when exposed to certain wavelengths of light. Healthcare providers can utilize this natural occurring process to objectively see these harmful pathogens. This may indicate that the host has a Sleep Related Breathing Disorder (SRBD). Sleep apnea is a primary disorder of SRBD’s. This technology offers medical and dental fields a screening tool for a pandemic healthcare problem.

Secondary health conditions in individuals with acquired long-term disabilities

The aim of this study is to advance our understanding of the secondary health conditions (SHCs) experienced by individuals with acquired long-term disabilities. This review is based on published literature and addresses the nature and perspectives associated with the phenomenon of disability, as well as the terminology used to describe it. The current understanding of SHCs limits and explains the range of information on somatic and mental illness with respect to the following criteria: SHCs are secondary to the primary disorder, they are preventable and modifiable, they manifest in different ways and for different durations of time, and that they exacerbate the severity of the primary condition. This review attempts to describe particular aspects associated with functioning in the context of acquired physical disabilities, practical implications of research on this subject, and perspectives for the future.

Case Report: Psychopathological Syndromes in the Course of Lupus Erythematosus and the Co-occurrence of Lupus Erythematous With Mental Disorders

Background: Systemic lupus erythematosus (SLE) is an autoimmune disease that leads to a chronic inflammatory process in tissues and organs. The neuropsychiatric systemic lupus erythematosus (NPSLE) is a set of neuropsychiatric symptoms that derive from the central and peripheral nervous system and are observed in the course of SLE.Case Report and Final Diagnostic and Therapeutic Results: A diagnostic and therapeutic process in a patient with the signs and symptoms of SLE and bipolar disorder (BD) has been described. Bipolar disorder has been diagnosed as a primary disorder while SLE as a comorbid disease.Discussion: Common immunological mechanisms in BD and SLE are the reason for difficulties in diagnosing BD with co-occurring SLE. It should be determined whether BD is a primary disorder or a secondary component of a clinical picture of SLE (NPSLE) or whether mood and/or psychotic disorders are the result of steroid therapy in the course of SLE (steroid-induced mood and psychotic disorders, SIMPD).Conclusion and the Patient's Perspective: The presented case report is a unique description of a patient with a primary diagnosis of BD with comorbid SLE.

Selection of Anti-Depressants in Geriatric Dermatoses- A Questionnaire Study of Dermatologists in Western Rajasthan, India

Background: The Global Wealth Migration Review 2019 report, published by New World Wealth, estimated that 48% of India's total wealth was held by high-net worth individuals. Distinct factors dominate the prescription of anti-depressants in the geriatric population. Accordingly, the intention of pharmacotherapy in geriatric psycho dermatoses is deciphered in the study. . Objective: To survey and analyze the selection of anti-depressants by the dermatologists in the practice of geriatric pharmacotherapy. Methods: A questionnaire was designed and circulated among ninety-three dermatologists in three sessions and the data collected was analyzed through the cross-sectional study statistics. Results: The typical senior people attending the specialist were 25-50%. A sizeable familiarity of psycho cutaneous disturbance was attributed to dermatophyte infections, lichen simplex chronic, and Prurigo in descending order. The largely established primary disorder was neurotic excoriation. The prescription pattern was classified and 51.9% dermatologists are customary with psychotropic agent Doxepin over other agents. The discipline of the multidisciplinary approach was also studied. Limitation: Small sample size, uniregional study, prevalence study. Conclusions: The survey aids in evaluating mental health in cutaneous dermatoses of the elderly and assists the dermatologists to offer understated economical options and amend existing guidelines.

Suspected Agomelatine-induced restless legs syndrome: a case report

Background Restless Legs Syndrome (RLS) is a sensorimotor disorder characterized by unpleasant and distressing sensations in the lower limbs that are more pronounced in the evening, commence or worsen at rest, and show partial or complete relief following movement. It can occur as a primary disorder, secondary to medical conditions or treatment with medications including but not limited to antidepressants or antipsychotics. Case presentation A 32-year old man with major depressive disorder showed partial response to Escitalopram 10 mg daily. Agomelatine 25 mg at night was added to Escitalopram to treat his residual depressive symptoms, namely insomnia and tiredness. Within two days he developed restlessness and unpleasant sensations in his legs which were worse at night. Symptom severity increased over the following days, prompting an urgent consultation a week later. The patient’s presentation met the criteria for RLS. Agomelatine was discontinued leaving the patient on Escitalopram alone. The patient’s symptoms improved within 24 h of stopping Agomelatine, with complete resolution four days later. There was no recurrence of RLS during follow-up. The patient scored 6 on Naranjo’s adverse drug reaction probability scale, indicating a probable adverse drug reaction caused by Agomelatine. Conclusions To the best of our knowledge, this is the first case report of suspected Agomelatine-induced RLS. Clinicians need to be aware of RLS to enable prompt diagnosis and management. We suggest adding Agomelatine to the list of agents that can potentially induce RLS.

Dysplasia, malformation, or deformity? - explanation of the basis of hip development disorders and suggestions for future diagnostics and treatment

This publication focuses on processes that disrupt the proper development of the hip. Four pathomechanisms underlying human developmental defects are described in the literature, i.e. dysplasia, malformation, disruption, and deformity. In the case of hip development, arguably the greatest challenge involves confusion between dysplasia and deformity, which often leads to misdiagnosis, incorrect nomenclature, and incorrectly chosen treatment. The paper presents a description of hip joint development disorders in the context of their pathomechanisms. An attempt was made to answer the question of whether these disorders are rooted in a primary disorder of tissue growth, resulting in its incorrect anatomy, or are the result of anatomical deformation with secondary modifications in tissue structures of a degenerative or adaptive nature, based on Deplesch-Heuter-Volkmann growth and remodeling laws. In addition, the emphasis is placed on attention to the presence of the so-called clinically and diagnostically mute cases. The need to augment diagnostic procedures with genetic tests to increase the sensitivity of screening has also been suggested. Based on the arguments presented in the paper, a new division of developmental hip disorders has been proposed.

Intralymphatic Histiocytosis: An Unusual Presentation

Intralymphatic histiocytosis (ILH) is a rare cutaneous condition initially described in 1994 by O’Grady et al. It often appears as a red to violaceous, livedoid patch or plaque usually on the extremities. We present a 71-year-old female with a history of psoriasis, 50 pack years smoking and recent Legionnaires disease who came to us complaining of a red to violaceous, blanching, edematous, mildly tender lesion covering the left lower lip and extending to the chin and anterior neck. After multiple biopsies, ILH was confirmed and the patient was initially started on tacrolimus 0.1% ointment b.i.d., but there was no response. Then, she was started on oral pentoxifylline and intermittent topical steroids, as well as continuing the topical tacrolimus. There was again no response, so now she is taking a TNF-ɑ inhibitor as it appears to be a granulomatous process. These ILH cases are very rare and there is limited literature that describes one treatment as a cure. Treatment of ILH is very difficult, but several different therapies have been reported with varying success. If the disease is secondary to an underlying inflammatory disease or malignancy, then treatment of the primary disorder can lead to resolution of the ILH.

Endocrine Causes of Secondary Osteoporosis in Adults: Mechanisms and Evaluation

Osteoporosis and fragility fractures are a major public health issue. Secondary osteoporosis is characterised by the presence of an underlying disease, deficiency, or use of a drug. Conditions that increase speculation for secondary osteoporosis include fragility fractures amongst the younger men or premenopausal women, markedly decreased Bone Mineral Density (BMD) values, and fractures despite conforming to anti-osteoporotic therapy. Since the emphasis is on the treatment of the primary disorder, a diagnosis of osteoporosis and thus the opportunity of preventive intervention can be missed. With this review, the authors objective is to emphasise the importance of secondary osteoporosis, discuss the causes and their mechanism and summarise treatment options.