scholarly journals A Case Definition for Children with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

2008 ◽  
Vol 1 ◽  
pp. CMPed.S978 ◽  
Author(s):  
Leonard A. Jason ◽  
Nicole Porter ◽  
Elizabeth Shelleby ◽  
David S. Bell ◽  
Charles W. Lapp ◽  
...  
Keyword(s):  
Chronic Fatigue Syndrome ◽  
Children And Adolescents ◽  
Sensitivity And Specificity ◽  
International Association ◽  
Chronic Fatigue ◽  
Case Definition ◽  
Myalgic Encephalomyelitis ◽  
Fatigue Syndrome ◽  
Reliable Instrument

The case definition for chronic fatigue syndrome was developed for adults (Fukuda et al. 1994), and this case definition may not be appropriate for use with children and adolescents. The lack of application of a consistent pediatric definition for this illness and the lack of a reliable instrument to assess it might lead to studies which lack sensitivity and specificity. In this article, a case definition is presented that has been endorsed by the International Association of ME/CFS.

scholarly journals Chronic fatigue syndrome and myalgic encephalomyelitis: towards an empirical case definition

2015 ◽  
Vol 3 (1) ◽  
pp. 82-93 ◽  
Author(s):  
Leonard A. Jason ◽  
Bobby Kot ◽  
Madison Sunnquist ◽  
Abigail Brown ◽  
Meredyth Evans ◽  
...  
Keyword(s):  
Chronic Fatigue Syndrome ◽  
Chronic Fatigue ◽  
Case Definition ◽  
Myalgic Encephalomyelitis ◽  
Fatigue Syndrome

scholarly journals Cell-Based Blood Biomarkers for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

2020 ◽  
Vol 21 (3) ◽  
pp. 1142
Author(s):  
Daniel Missailidis ◽  
Oana Sanislav ◽  
Claire Y. Allan ◽  
Sarah J. Annesley ◽  
Paul R. Fisher
Keyword(s):  
Chronic Fatigue Syndrome ◽  
Sensitivity And Specificity ◽  
Respiratory Function ◽  
Death Rate ◽  
Frozen Storage ◽  
Chronic Fatigue ◽  
Myalgic Encephalomyelitis ◽  
Healthy Controls ◽  
Fatigue Syndrome ◽  
Mitochondrial Respiratory

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a devastating illness whose biomedical basis is now beginning to be elucidated. We reported previously that, after recovery from frozen storage, lymphocytes (peripheral blood mononuclear cells, PBMCs) from ME/CFS patients die faster in culture medium than those from healthy controls. We also found that lymphoblastoid cell lines (lymphoblasts) derived from these PBMCs exhibit multiple abnormalities in mitochondrial respiratory function and signalling activity by the cellular stress-sensing kinase Target Of Rapamycin Complex 1 (TORC1). These differences were correlated with disease severity, as measured by the Richardson and Lidbury weighted standing test. The clarity of the differences between these cells derived from ME/CFS patient blood and those from healthy controls suggested that they may provide useful biomarkers for ME/CFS. Here, we report a preliminary investigation into that possibility using a variety of analytical classification tools, including linear discriminant analysis, logistic regression and receiver operating characteristic (ROC) curve analysis. We found that results from three different tests—lymphocyte death rate, mitochondrial respiratory function and TORC1 activity—could each individually serve as a biomarker with better than 90% sensitivity but only modest specificity vís a vís healthy controls. However, in combination, they provided a cell-based biomarker with sensitivity and specificity approaching 100% in our sample. This level of sensitivity and specificity was almost equalled by a suggested protocol in which the frozen lymphocyte death rate was used as a highly sensitive test to triage positive samples to the more time consuming and expensive tests measuring lymphoblast respiratory function and TORC1 activity. This protocol provides a promising biomarker that could assist in more rapid and accurate diagnosis of ME/CFS.

A Pediatric Case Definition for Myalgic Encephalomyelitis and Chronic Fatigue Syndrome

2006 ◽  
Vol 13 (2-3) ◽  
pp. 1-44 ◽  
Author(s):  
Leonard A. Jason ◽  
Karen Jordan ◽  
Teruhisa Miike ◽  
David S. Bell ◽  
Charles Lapp ◽  
...  
Keyword(s):  
Chronic Fatigue Syndrome ◽  
Chronic Fatigue ◽  
Case Definition ◽  
Myalgic Encephalomyelitis ◽  
Pediatric Case ◽  
Fatigue Syndrome

scholarly journals Cell-Based Blood Biomarkers for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

2020 ◽  
Author(s):  
Daniel Missailidis ◽  
Oana Sanislav ◽  
Claire Allan ◽  
Sarah Annesley ◽  
Paul Fisher
Keyword(s):  
Chronic Fatigue Syndrome ◽  
Sensitivity And Specificity ◽  
Respiratory Function ◽  
Death Rate ◽  
Frozen Storage ◽  
Chronic Fatigue ◽  
Myalgic Encephalomyelitis ◽  
Healthy Controls ◽  
Fatigue Syndrome ◽  
Mitochondrial Respiratory

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a devastating illness whose biomedical basis is now beginning to be elucidated. We reported previously that, after recovery from frozen storage, lymphocytes (peripheral blood monocytic cells, PBMCs) from ME/CFS patients die faster in culture medium than those from healthy controls. We also found that lymphoblastoid cell lines (lymphoblasts) derived from these PBMCs exhibit multiple abnormalities in mitochondrial respiratory function and signalling activity by the cellular stress-sensing kinase TORC1. These differences were correlated with disease severity, as measured by the Richardson and Lidbury Weighted Standing Test. The clarity of the differences between these cells derived from ME/CFS patient blood and those from healthy controls suggested that they may provide useful biomarkers for ME/CFS. Here we report a preliminary investigation into that possibility using a variety of analytical classification tools, including linear discriminant analysis, logistic regression and Receiver Operating Characteristic (ROC) curve analysis. We found that results from three different tests, lymphocyte death rate, mitochondrial respiratory function and TORC1 activity could each individually serve as biomarker with better than 90% sensitivity but only modest specificity vís a vís healthy controls. However, in combination they provided a cell-based biomarker with sensitivity and specificity approaching 100% in our sample. This level of sensitivity and specificity was almost equalled by a suggested protocol in which the frozen lymphocyte death rate was used as a highly sensitive test to triage positive samples to the more time consuming and expensive tests measuring lymphoblast respiratory function and TORC1 activity. This protocol provides a promising biomarker that could assist in more rapid and accurate diagnosis of ME/CFS.

Chronic Fatigue Immune Dysfunction Syndrome: An Epidemic?

PEDIATRICS ◽  
1992 ◽  
Vol 89 (4) ◽  
pp. 804-804
Author(s):  
MUDR ALEŠ KMINEK ◽  
MUDR IVO SIMUNEK
Keyword(s):  
Chronic Fatigue Syndrome ◽  
Children And Adolescents ◽  
Immune Dysfunction ◽  
Chronic Fatigue ◽  
Case Definition ◽  
Fatigue Syndrome ◽  
Definition Of ◽  
Mild Fever

To the Editor.— We read with great interest the article "Chronic Fatigue in Adolescents" by Smith et al in the August 1991 issue.1 We appreciate the statement by the authors that "the CDC-recommended criteria for case definition of the chronic fatigue syndrome (CFS) were developed mainly from adult populations and may not be appropriate for children and adolescents." We have studied children suffering from unexplained fatigue, mild fever, nonexudative pharyngitis, lymphadenopathia, etc, since 1987, ie, prior to publication of CDC-recommended criteria of CFS.2

scholarly journals Sensitivity and Specificity of the CDC Empirical Chronic Fatigue Syndrome Case Definition

Psychology ◽  
2010 ◽  
Vol 01 (01) ◽  
pp. 9-16 ◽  
Author(s):  
Leonard A. Jason ◽  
Meredyth Evans ◽  
Abigail Brown ◽  
Molly Brown ◽  
Nicole Porter ◽  
...  
Keyword(s):  
Chronic Fatigue Syndrome ◽  
Sensitivity And Specificity ◽  
Chronic Fatigue ◽  
Case Definition ◽  
Chronic Fatigue Syndrome Case ◽  
Fatigue Syndrome

scholarly journals Review of case definitions for myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)

2020 ◽  
Vol 18 (1) ◽  
Author(s):  
Eun-Jin Lim ◽  
Chang-Gue Son
Keyword(s):  
Chronic Fatigue Syndrome ◽  
Orthostatic Intolerance ◽  
Chronic Fatigue ◽  
Case Definition ◽  
Myalgic Encephalomyelitis ◽  
Case Definitions ◽  
Fatigue Syndrome ◽  
Mesh Terms ◽  
Duration Of Illness ◽  
Primary Disorder

Abstract Background Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating disease with unknown causes. From the perspectives on the etiology and pathophysiology, ME/CFS has been labeled differently, which influenced changes in case definitions and terminologies. This review sought to feature aspects of the history, developments, and differential symptoms in the case definitions. Methods A search was conducted through PubMed published to February 2020 using the following search keywords: case definition AND chronic fatigue syndrome [MeSH Terms]. All reference lists of the included studies were checked. Of the included studies, the number of citations and the visibility in the literatures of the definitions were considered for comparisons of the criteria. Results Since the first 'ME' case definition was developed in 1986, 25 case definitions/diagnostic criteria were created based on three conceptual factors (etiology, pathophysiology, and exclusionary disorders). These factors can be categorized into four categories (ME, ME/CFS, CFS, and SEID) and broadly characterized according to primary disorder (ME-viral, CFS-unknown, ME/CFS-inflammatory, SEID-multisystemic), compulsory symptoms (ME and ME/CFS-neuroinflammatory, CFS and SEID-fatigue and/or malaise), and required conditions (ME-infective agent, ME/CFS, CFS, SEID-symptoms associated with fatigue, e.g., duration of illness). ME and ME/CFS widely cover all symptom categories, while CFS mainly covers neurologic and neurocognitive symptoms. Fatigue, cognitive impairment, PEM, sleep disorder, and orthostatic intolerance were the overlapping symptoms of the 4 categories, which were included as SEID criteria. Conclusions This study comprehensively described the journey of the development of case definitions and compared the symptom criteria. This review provides broader insights and explanations to understand the complexity of ME/CFS for clinicians and researchers.

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