This chapter will provide a strategic approach and firsthand insight into the best practices for Nyack Hospital’s User Community “Gateway to NH Medical Library Resources” Virtual Library 24/7 service. In an effort to maximize Library and Information Services (LIS) while minimizing the department’s planned budget and licensing fees, the author will share current practices of the knowledge-based information needs of the Hospital: Nyack Hospital and LIS Mission/Goals/Objectives, US Federal Government Mandates for Electronic Medical Records (EMR), Nyack’s McKesson Paragon Hospital Information System, Coordination of Knowledge Management – eResources (Web-version) and the function of hard copy, Acquisition, Annual Licensing Agreement (Institutional), Dissemination, and Preservation of Information Resources, Coordination with Southeastern New York Library Research Council (SENYLRC) and Hospital Library Program Services (HLSP), Extensive Literature Search and Document Delivery Services thru NLM/DOCLINE and ILL, End-User Orientation and Training, Continuing Medical Education (CME) Services. The author will present the current status of the state-of-the-art Med Lib Research Info Center and conclude with the future direction of the Research Learning Center.