COMPARATIVE STUDY OF PLATELET COUNT IN DIABETIC AND NON-DIABETIC GERIATRIC POPULATION

Geriatric population (> 60 years) is rapidly increasing in India, It has been increased upto 8.6% in 2011. Diabetes Mellitus (DM) is a metabolic disorder and a major health problem, a?ecting a large section of the Indian population, especially as its incidence increases with advancing age. Host of complications are associated with this disease, one of which is the e?ect on platelet count. This study compares platelet count between diabetic and non-diabetic elderly. It is observed that Hyperglycaemia in diabetic persons is responsible for increased Thrombopoietin production at the cellular level, which leads to raised platelet count -Reticulated Thrombocytosis – when compared to non diabetics. Platelets, especiallyreticulated thrombocytes are associated with uncontrolled blood sugar levels in the body and are well known for their role in artherosclerotic cardiovascular disease (CVD). Keywords: platelet count, diabetic and non-diabetic & geriatric.

Comparison of Routine Risk Factors for Atherosclerosis in Arab and Lor Patients

Background: The awareness of the risk factors of atherosclerosis and attempts to correct and control them can effectively reduce the risk of complications. Objectives: This study was performed to evaluate the risk factors for routine atherosclerosis in patients with symptoms of heart disease in the Arab race, compared to those of Lor patients. Methods: This descriptive-analytical study was conducted on 200 patients with symptoms of heart disease. A food frequency questionnaire was used for data collection. Results: Out of 200 patients, 101 (51.5%) and 99 (48.5%) participants were Lor and Arab, respectively. Significant differences were observed between the two races for cholesterol and fasting blood sugar levels (P < 0.05). Additionally, no significant difference was observed between different quarters of following dietary patterns and lipid-glucose factors (P > 0.05). Conclusions: Risk factors for cardiovascular diseases, such as atherosclerosis, are multifactorial. Various factors can effectively affect the prevalence of this disease in each region, which necessitates the identification of risk factors to take steps to correct risk factors and improve the quality of patients’ life.

Physical Activity and Blood Sugar Levels in People with Diabetes Mellitus: Evidence from Indonesia

Diabetes mellitus (DM) is a slowly deadly disease. Indonesia has the 4th highest number of diabetes mellitus after China, India and the United States. People with diabetes have grown from 8.4 million in 2000 and will become 21.3 million in 2030. This study aims to determine the relationship between body movement and blood sugar levels in patients with type 2 diabetes mellitus. This type of research is quantitative, with a design analytical research and cross-sectional approach. The sample of this study was 131 people with the criteria for suffering from type 2 diabetes mellitus. Data collection used the Global Body Movement Questionnaire (GPAQ) questionnaire, and the statistical test used was the Chi-Square statistical test. The results showed that there was a relationship between physical activity and blood sugar levels in patients with type 2 diabetes mellitus, so it is recommended that DM patients should routinely carry out body movements and control blood sugar levels in health care facilities and take advantage of health services such as health workers if they experience problems in performing body movements and follow a diabetic diet according to the advice of a nutritionist. In-depth conclusions and implications are discussed.

The Response of Cowpea (Vigna unguiculata) Plants to Three Abiotic Stresses Applied with Increasing Intensity: Hypoxia, Salinity, and Water Deficit

Exposing plants to gradually increasing stress and to abiotic shock represents two different phenomena. The knowledge on plants’ responses following gradually increasing stress is limited, as many of the studies are focused on abiotic shock responses. We aimed to investigate how cowpea (Vigna unguiculata (L.) Walp.) plants respond to three common agricultural abiotic stresses: hypoxia (applied with the increasing time of exposure to nitrogen gas), salinity (gradually increasing NaCl concentration), and water deficit (gradual decrease in water supply). We hypothesized that the cowpea plants would increase in tolerance to these three abiotic stresses when their intensities rose in a stepwise manner. Following two weeks of treatments, leaf and whole-plant fresh weights declined, soluble sugar levels in leaves decreased, and lipid peroxidation of leaves and roots and the levels of leaf electrolyte leakage increased. Polyphenol oxidase activity in both roots and leaves exhibited a marked increase as compared to catalase and peroxidase. Leaf flavonoid content decreased considerably after hypoxia, while it increased under water deficit treatment. NO emission rates after 3 h in the hypoxically treated plants were similar to the controls, while the other two treatments resulted in lower values of NO production, and these levels further decreased with time. The degree of these changes was dependent on the type of treatment, and the observed effects were more substantial in leaves than in roots. In summary, the responses of cowpea plants to abiotic stress depend on the type and the degree of stress applied and the plant organs.

Modulation of sugar feeding behavior by Gymnema sylvestre in Drosophila melanogaster

Introduction: Sugar is the main source of energy for nearly all animals. However, consumption of a high amount of sugars can lead to many metabolic disorders hence, balancing calorie intake in the form of sugar is required. Various herbs are in use to control body weight, cure diabetes and control elevated blood sugar levels. One such herb is Gymnema sylvestre commonly called Gurmar (destroyer of sugar). Gurmar selectively inhibits sugar sensation by mechanisms that are still elusive. Objectives: The primary objective of this study is to understand the effect of gurmar on sweet taste feeding behaviour in insects using the invertebrate model system Drosophila melanogaster. Methods: For this study, we used feeding assays, spectrophotometry and Proboscis Extension Reflex (PER) assay to determine how flies detect gurmar. Additionally, life span analysis, egg-laying behaviour and developmental profiles were used to probe the role of gurmar on the overall health of the flies. During the whole study, we used only the raw powdered form of gurmar (dried leaves) to examine its effect on sweet taste feeding behaviour. Results: Our data demonstrate that whole gurmar in a raw powdered form is aversive to flies and inhibits sugar evoked PER and feeding responses. Also, we observed it takes at least 24 h of starvation time to reduce the consumption of sugar in flies pre-fed on gurmar. Flies lay a fewer number of eggs on gurmar media and show developmental defects. Our data suggest that flies detect gurmar using both taste and olfactory cues. Conclusion: Understanding how gurmar reshapes taste curves to promote reduced consumption of sugars in flies will open up avenues to help people with health issues related to high sugar consumption, but our data also highlights that its consumption should be carefully considered since gurmar is aversive to flies and has detrimental effects on development.

Pathological and radiological irregularities in patients with chronic kidney disease - An observational study

Background: Chronic kidney disease (CKD) encompasses a spectrum of different pathophysiologic processes associated with abnormal renal function and progressive decline in glomerular filtration rate (GFR). Aims and Objectives: The objectives of the study are 1) to assess basic tests and kidney function tests in patients with CKD, (2) to assess coagulation profile, sugar levels, and platelets levels in patients of CKD, (3) to do the urine analysis in patients with CKD, and (4) to assess GFR among the study population. Materials and Methods: After taking the informed consent, detailed history was taken and clinical examination of patient was done. Pathological tests such as hemogram, renal function tests, liver function tests, coagulation profile, blood sugar levels, urine routine, and microscopy were performed. Ultrasonography of abdomen and pelvis was done. Correlation was done between severity of sepsis and mortality in patients. Results: Anemia was moderate (7–8.9 g/dl) in 38%, mild (9–10.9 g/dl) in 31%, while severe (<6.9) in 29 patients, that is, 29%. Thrombocytopenia was present in 58% of patients. Mean serum albumin in patients was 2.67±0.551 mg/dl; serum globulin was 3.89±0.345 mg/dl. Mean blood sugar of study subjects was 127.41±61.387 mg/dl fasting, 199.67±114.827 mg/dl post-prandial, and mean glycated hemoglobin was 5.63 ± 1.668. On ultrasound acute pyelonephritis, 25 (25%) was the most common finding. Conclusion: Correlation of clinical findings with pathological and radiological findings is very important in patients with CKD. Severity of sepsis directly correlates with mortality of patients.

Telemedicine-Based Diabetic Care Powered With Artificial Intelligence

Diabetes is one of the chronic diseases which keep increasing at an alarming rate, and the patients need to visit the clinic to routinely check their sugar levels and adjust their treatment plans. Artificial intelligence-enabled telemedicine is found to be a promising approach to monitor the health status of diabetic patients. Some of the promising artificial intelligence technologies for treating diabetic patients are a reactive machine, limited memory, theory of minds, and self-awareness. Each of these techniques is discussed with architecture, characteristics, algorithms, advantages, and applications. Performance analysis is carried out towards the performance metrics like accuracy, medical error rate, speed, and learning rate, and the performance achieved by self-awareness artificial intelligence technique is found to be better in delivering telemedicine-based care for diabetic patients with a very high level of precision and speed of operation.

Hypoglycemic Effect of Lycopersicon esculentum (Tomato) on Alloxan-Induced Diabetic Rats

Diabetes mellitus has been a key degenerative disease affecting the world’s population. Lycopersicon esculentum (Tomato), a fruit consumed by many and known to have certain phytochemicals was used to determine its hypoglycemic effect on alloxan induced diabetic rats. The tomato was dried, pulverized and dissolved in distilled water and administered orally to albino rats in various concentrations according to their body weight. 30 albino rats were divided into 6 groups of 5 rats each. Groups I and II served as normal and diabetic control respectively, while groups III to VI were induced with diabetes and treated with different concentrations of the prepared tomato. After 14 days of treatment with various concentrations of tomato, there was a marked decrease in blood sugar levels at all the study concentrations. The result of the lipid profile a significant increase (p<0.05) in total cholesterol (150.67±7.02 mg/dL), triglyceride (159.33±5.03 mg/dL), LDL-Cholesterol (77.53±1.83 mg/dL) and a decrease in HCL-Cholesterol (51.67±1.00 mg/dL) levels in untreated diabetic rats when compared to the normal control. Upon treatment with 200 mg/kg of tomato, there was a significant decrease (p< 0.05) in the levels of Triglyceride, total cholesterol and LDL-cholesterol and an increase in the HDL-cholesterol. These results suggest that tomato may have the ability to reduce blood sugar level and the risk of cardiovascular disease.

The Role of Atom Shadow on Sorbitol Molecules to Heal Diabetic Diseases

Sorbitol has a low calorie value, this is due to the presence of a pair of O-H free electrons on the sorbitol molecule. The pair of free electrons can be removed by the Tunnel method (through the shadow of the sorbitol container). Sorbitol which has lost a pair of free electrons from the O-H group is called sorbitol switching. The instrument used to prove the release of a pair of free electrons in the O-H group is to use FTIR and clinical trials conducted on mice given sorbitol to prove the effectiveness between sorbitol and sorbitol switching. The results show that sorbitol switching is able to maintain the stability of blood sugar levels in the body of mice and can reduce blood sugar levels.

Nutritional Content and Health Profile of Single-Serve Non-Dairy Plant-Based Beverages

A growing number of people are seeking a non-dairy plant-based beverage both for their personal health, and for the health of the planet. The aim of this study was to conduct a cross-sectional survey of single-serve plant-based beverages to assess their nutritional content and health profile. A total of 51 non-dairy plant-based beverages were analyzed from the nutrition label listed on the commercial package. The various beverages contained extracts of soy (n = 14), almonds (n = 13), oats (n = 12), peas (n = 7), banana (n = 2), coconut (n = 2), and rice (n = 1). Almost one-half (45%) of the single-serve beverages had 5 g or more of protein/serving. A total of 75% and 65% of the single-serve beverages had calcium and vitamin B12 levels, respectively, fortified to at least 20% of the Daily Value (DV), while only 28% had vitamin D fortification at the 20% DV level. Two-thirds of the single-serve beverages had high sugar levels, while 39% were low in sodium, 63% were low in fat, and 96% were low in saturated fat. The single-serve plant-based beverages had more protein, calcium, vitamin B12, and sugar but less fat than the non-dairy, multi-serve plant-based beverages/ serving. A limited number of single-serve beverages met the requirements of school meal programs.