A Photonic Crystal Fiber based on Surface Plasmon Resonance (PCF-SPR) temperature sensor with liquid core is proposed in this paper. Glycerin liquid with a high refractive index is filled in the central air hole of the hollow core photonic bandgap (PBG) PCF, the transmission type of PCF will change to total internal reflection (TIR), which will significantly broaden its transmission bands. The refractive index of glycerin changes with temperature within a certain temperature range and can be detected by measuring the transmission spectra, thus the accurate ambient temperature can be obtained. Numerical results indicate that the plasmon on the surface of the gold-coated channels containing glycerin liquid can be intensively excited by the core-guided mode and the excitation of the plasmon mode is sensitive to the change of the temperature. Resolution of the PCF-SPR temperature sensor with liquid core is demonstrated to be as low as 4 × 10-6 RIU, where RIU means refractive index unit.