Concurrent MRI and Diffuse Correlation & Near-Infrared Spectroscopic Measurement of Cerebral Hemodynamic Response to Hypercapnia and Hyperoxia

We studied cerebral hemodynamic response to a sequential motor task in 56 subjects to investigate the time course and distribution of blood oxygenation changes as monitored by near-infrared spectroscopy (NIRS). To address whether response is modulated by different performance velocities, a group of subjects (n = 12) was examined while performing the motor task at 1, 2, and 3 Hz. The results demonstrate that 1) the NIRS response reflects localized changes in cerebral hemodynamics, 2) the response, consisting of an increase in oxygenated hemoglobin concentration [oxy-Hb] and a decrease in deoxygenated hemoglobin concentration ([deoxy-Hb]), is lateralized and increases in amplitude with higher performance rates, and 3) changes in [oxy-Hb] and [deoxy-Hb] differ in time course. Changes in [oxy-Hb] are biphasic, with a fast initial increase and a pronounced poststimulus undershoot. The stimulus-associated decrease in [deoxy-Hb] is monophasic, and response latency is greater. We conclude that NIRS is able to detect even small changes in cerebral hemodynamic response to functional stimulation.

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A review on recent near infrared spectroscopic measurement setups and their challenges

Measurement ◽

10.1016/j.measurement.2020.108732 ◽

2021 ◽

Vol 171 ◽

pp. 108732

Author(s):

Fan Wei Hong ◽

Kim Seng Chia

Keyword(s):

Near Infrared ◽

Spectroscopic Measurement ◽

Infrared Spectroscopic

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Age-dependent cerebral hemodynamic effects of indomethacin in the newborn piglet

Journal of Applied Physiology ◽

10.1152/japplphysiol.01396.2003 ◽

2004 ◽

Vol 97 (5) ◽

pp. 1880-1887 ◽

Cited By ~ 6

Author(s):

Derek W. Brown ◽

David Lee ◽

Vazhkudai S. Kumaran ◽

Ting-Yim Lee

Keyword(s):

Near Infrared ◽

Cerebral Blood Volume ◽

Ductus Arteriosus ◽

Hemodynamic Response ◽

Oxygen Extraction Fraction ◽

Postnatal Life ◽

Dependent Manner ◽

Hemodynamic Effects ◽

Cerebral Hemodynamic ◽

Age Dependent

With recent discussions in the literature regarding prophylactic use of early (within the first 12 h after birth), low-dose indomethacin to reduce the incidence and severity of intraventricular hemorrhage, knowledge pertaining to the cerebral hemodynamic effects of indomethacin in this age group is of significant interest. The cerebral circulation is known to undergo significant changes during the first few days of postnatal life. In the present study, we have investigated the hypothesis that postnatal adaptive changes influence the cerebral hemodynamic response to indomethacin in an age-dependent manner. Near-infrared spectroscopy with indocyanine green was used to measure cerebral hemodynamics, cerebral metabolic rate of oxygen, and cerebral oxygen extraction fraction in 39 newborn piglets. Piglets were grouped by age and received either 0.2 mg/kg indomethacin (14 were <13 h of age and 12 were >13 h of age) or saline (8 were <13 h of age and 5 were >13 h of age) infusions. In a subgroup of indomethacin-treated piglets (9 less than and 7 greater than 13 h of age), Doppler flow ultrasound was used to diagnose and monitor the presence and persistence of patent ductus arteriosus. Age was a significant factor in the cerebral hemodynamic response to indomethacin with piglets <13 h of age exhibiting delayed increases in cerebral blood flow and cerebral blood volume at 150 min post-indomethacin infusion.

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