Classical Cornelia de Lange syndrome in a neonate

Cornelia de Lange syndrome is a rare developmental disorder syndrome involving multiple systems characterized by facial dysmorphism limb deformities, hirsutism, cardiac defects, growth and cognitive retardation, and gastrointestinal abnormalities. The features of this disorder range from mild to severe. We present here a case of preterm newborn with Classical Cornelia de Lange syndrome with heterozygous mutation in NIBPL gene.

Level of Anxiety among the Mothers of Preterm Newborn Admitted in Nicu Ward

Background: Premature birth has a great impact on the parents. In India, 27 million babies are born each year out of which 3.5 million babies are born premature. This study included premature infants <37 weeks of gestation. Preterm birth may have a negative impact on parents’ experience as well In fact, the premature birth of the baby suddenly interrupts the building of parents’ mental representations and expectations. Aim and Objective: The purpose of this study was to assess the level of anxiety among the mothers of preterm newborn admitted in NICU ward and to find out the association between the level of anxiety among the mothers of preterm newborn with their demographic variable. Design and Methods: A descriptive study was carried out on 50 mothers of premature newborn. Who were admitted to the neonatal intensive care unit of selected hospital, vadodara. Purposive sampling technique was used to collect the data. Descriptive and inferential statistics were applied to analyses the data by using SPSS-20 software. The samples in this study was selected by non randomised sampling technique. Mothers anxiety regarding the newborn were determined by Hamilton anxiety rating scale. Data was collected by applying Inclusion Criteria like Mothers of preterm who were willing to participate , who were admitted in the hospital. Results: The majority of mothers the study finding of qualitative data reveals that the mothers level of anxiety 10% mild, 10% moderate, 22% severe, 58% very severe. The linear regression analysis showed that anxiety level was at significance of 0.05 level. Association between age and birth weight in demographic variables. Conclusion: The present study concluded level of anxiety 10% mothers of having mild anxiety, 10% were having moderate anxiety, 22% were having severe anxiety, 58% were having very severe anxiety. The linear regression analysis showed that anxiety level was at significance of 0.05 level.

Preterm Newborn Adaptive Responses to Daily Nursing during Neonatal Intensive Care Unit Stay, Associate with Neurodevelopment, 2 Years Later

Objective This study aimed to evaluate if adaptive responses of very preterm newborns to neonatal intensive care unit (NICU) daily nursing, specifically bathing and weighing procedures are associated with their neurodevelopment after 2 years. Study Design Twenty-six very preterm newborns, with a gestational age <32 weeks, were enrolled. Infants' adaptive responses to daily nursing were evaluated, at 30 to 32 to 35 postmenstrual age (PMA) weeks by an observational sheet. Neurodevelopment was assessed at 24 months of corrected age by the Bayley Scales of Infant and Toddler Development, third edition. Autonomic, motor, and self-regulatory responses to NICU nursing were analyzed by Spearman's correlation coefficient and multivariate linear regression with Bayley's cognitive, language, and motor scales. Results Significant (p < 0.05) positive correlations of self-regulatory and autonomic responses to nursing with all Bayley's scales were found at 30- and 32-week PMA. At 35-week PMA, only self-regulatory responses had significant positive correlations with all Bayley's scales. When adjusted for birth weight and sex, the significant associations were confirmed only at 30- and 32-week PMA. Conclusion Very preterm newborn adaptive responses to NICU daily nursing reveal to be positively related to forthcoming neurodevelopment 2 years later, as early as the 30-week PMA. Helping preterm babies to adapt to daily NICU nursing may promote their future neurobehavior. Key Points

Preterm newborn adaptive responses to daily nursing, during NICU stay, associate with the neurodevelopment, two years later

Objective: To evaluate if adaptive responses of very preterm newborns to NICU daily nursing, specifically bathing and weighing procedures, are associated with their neurodevelopment two years later. Study design: Twenty-six very preterm newborns, with a gestational age < 32 weeks, were enrolled. Infants' adaptive responses to daily nursing were evaluated, at 30-32-35 postmenstrual age (PMA) weeks, by an observational sheet. Neurodevelopment was assessed, at 24 months of corrected age, by the Bayley Scales of Infant and Toddler Development, third edition. Autonomic, motor, and self-regulatory responses to NICU nursing were analyzed, by Spearman's correlation coefficient and multivariate linear regression, with Bayley’s cognitive, language, and motor scales. Results: Significant (P < 0.05) positive correlations of self-regulatory and autonomic responses to nursing with all Bailey’s scales were found at 30- and 32-weeks PMA. At 35 weeks PMA, only self-regulatory responses had significant positive correlations with all Bailey’s scales. When adjusted for birth weight and sex, the significant associations were confirmed only at 30- and 32-weeks PMA. Conclusion: Very preterm newborn adaptive responses to NICU daily nursing reveal to be positively related to forthcoming neurodevelopment two years later, as early as the 30th week PMA. Helping preterm babies to adapt to daily NICU nursing may promote their future neurobeahaviour.

Neonatal SARS-CoV-2 infection: is this a vertical transmission?

Neonatal COVID-19, its manifestations and transmission, remains unclear. As the pandemic continues more evidence will emergebut so far, vertical transmission of COVID-19 is rare with just a few reports in the literature. We share our experience of managinga preterm newborn with COVID-19 in our neonatal intensive care unit (NICU) where the vertical route seems the most likelymode of transmission.