Methylene blue-filled biodegradable polymer particles as a contrast agent for optical coherence tomography

In this paper, the contrasting properties of titanium dioxide nanoparticles in various compositions were considered. In the course of the work, methods for the synthesis of oxide materials SiO2-TiO2, SiO2-ZrO2, TiO2-ZrO2 and SiO2-TiO2-ZrO2 were developed; the microstructure of oxide materials SiO2-TiO2, SiO2-ZrO2, TiO2-ZrO2and SiO2-TiO2-ZrO2was studied; the stability of oxide materials SiO2-TiO2, SiO2-ZrO2, TiO2-ZrO2and SiO2-TiO2-ZrO2 was determined. The elemental composition of the oxide materials SiO2-TiO2, SiO2-ZrO2, TiO2-ZrO2and SiO2-TiO2-ZrO2 has also been studied using SEM and XRD methods. It was found that SiO2-TiO2-ZrO2 nanocomposites with content of titanium dioxide from 8 to 9.5 % and zirconium dioxide from 0.5 to 2 % are completely insoluble in a highly alkaline medium. Thus, this composition is the most optimal for use as a contrast agent in optical coherence tomography.

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Quantitative evaluation of nanoshells as a contrast agent for optical coherence tomography

10.1117/12.632991 ◽

2005 ◽

Author(s):

Anant Agrawal ◽

Stanley Huang ◽

Min-Ho Lee ◽

T. J. Pfefer ◽

Rebekah Drezek

Keyword(s):

Optical Coherence Tomography ◽

Contrast Agent ◽

Quantitative Evaluation ◽

Optical Coherence

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Optical Coherence Tomography Angiography in Retinal Diseases

Güncel Retina Dergisi (Current Retina Journal) ◽

10.37783/crj-0011 ◽

2017 ◽

pp. 69-74

Keyword(s):

Optical Coherence Tomography ◽

Contrast Agent ◽

Optical Coherence Tomography Angiography ◽

Imaging Method ◽

Retinal Diseases ◽

Optical Coherence ◽

Vascular Networks ◽

Motion Contrast ◽

Choroidal Vasculature

Optical coherence tomography angiography (OCTA) is a new imaging method providing the assessment of retinal and choroidal vasculature without a contrast agent. In this angiography type, the vascular networks have been visualized in detail though detecting motion contrast of erythrocytes in the vessel, using serial optical coherence tomography B-scans. Currently, OCTA findings of many retinal diseases have been reported.

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P3385Difference of vascular healing after percutaneous coronary intervention between 4 kinds of new generation drug-eluting stents: an optical coherence tomography analysis

European Heart Journal ◽

10.1093/eurheartj/ehz745.0261 ◽

2019 ◽

Vol 40 (Supplement_1) ◽

Author(s):

Y Matsuhiro ◽

M Nishino ◽

H Nakamura ◽

K Yasumoto ◽

A Tanaka ◽

...

Keyword(s):

Optical Coherence Tomography ◽

Biodegradable Polymer ◽

Neointimal Hyperplasia ◽

Drug Eluting Stents ◽

P Value ◽

Optical Coherence ◽

Durable Polymer ◽

Drug Eluting ◽

New Generation

Abstract Background New generation drug eluting stents (DES) have improved target vessel failure as compared with early generation DES and bare metal stent. Contemporary several new generation DES are different each other regarding strut thickness and drug and polymer type. A little is known about which stent induces a more favorable vascular healing at follow up. Purpose In this study, we compared the vascular healing at 8-month follow up by optical coherence tomography (OCT) between 4 different kinds of new generation DES. Methods We enrolled 112 consecutive patients (121 lesions) who underwent PCI using 4 kinds of new generation DES including biodegradable-polymer everolimus-eluting stents (BP-EES), biodegradable-polymer sirolimus-eluting stents (BP-SES), durable-polymer everolimus-eluting stents (DP-EES) and durable-polymer zotarolimus-eluting stents (DP-ZES) and who underwent 8-month follow up angiogram and OCT between July 2016 and April 2018. We compared the OCT parameters including percentage of covered struts, uncovered struts, well-apposed and uncovered struts, malapposed strut and mean neointimal hyperplasia (NIH) thickness between them. Results BP-EES consisted of 29 lesions, BP-SES consisted of 25 lesions, DP-EES consisted of 38 lesions and DP-ZES consisted of 29 lesions. A total of 734 frames with 5163 struts in BP-EES, 481 frames with 4214 struts in BP-SES, 783 frames with 6119 struts in DP-EES and 583 frames with 4708 struts in DP-ZES were analyzed. As shown in a table, mean NIH thickness was significantly higher in BP-EES and BP-SES. Thus, we compared the OCT parameters between durable-polymer (DP) group including DP-ZES and DP-EES and biodegradable-polymer (BP) group including BP-EES and BP-SES. The percentage of uncovered struts was significantly lower and mean NIH thickness was significantly higher in BP group than DP group. Results of OCT parameters BP-EES (n=29) BP-SES (n=25) DP-EES (n=38) DP-ZES (n=29) P value BP group (n=54) DP group (n=67) P value Covered struts (%) 89.5±13.6 92.4±8.6 85.5±17.5 85.0±17.7 0.29 90.9±11.6 85.3±17.4 0.08 Uncovered struts (%) 8.8±10.8 7.1±8.7 14.5±17.5 15.0±17.7 0.14 8.0±9.9 14.7±17.4 0.03 Well-apposed and uncovered struts (%) 7.9±9.9 5.9±7.7 11.7±13.1 12.3±14.0 0.15 7.0±8.9 11.9±13.4 0.04 Malapposed struts (%) 0.8±1.6 1.3±2.2 2.7±5.8 2.7±4.7 0.33 1.0±1.9 2.7±5.3 0.07 Mean NIH thickness (μm) 102±57 121±48 78±28 88±33 <0.01 111±53 82±31 <0.01 Conclusion The present OCT study demonstrated that delayed neointimal healing characterized by the presence of uncovered struts and lower mean NIH thickness was less common in BP group than DP gruop. Biodegradable-polymer may be more favorable than durable-polymer from the point of view of vascular healing.

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