scholarly journals In vivo two-dimensional quantitative imaging of skin and cutaneous microcirculation with perturbative spatial frequency domain imaging (p-SFDI)

2021 ◽  
Author(s):  
Wei Lin ◽  
YANG ZHENG ◽  
ZHEN LI ◽  
Xin Jin ◽  
Zili Cao ◽  
...  
Keyword(s):  
Spatial Frequency ◽  
Frequency Domain ◽  
Quantitative Imaging ◽  
Two Dimensional ◽  
Spatial Frequency Domain Imaging ◽  
Cutaneous Microcirculation ◽  
Spatial Frequency Domain

360 In Vivo Characterization of Burn Wound and Skin Graft Healing in a Porcine Model using Spatial Frequency Domain Imaging

2019 ◽  
Vol 40 (Supplement_1) ◽  
pp. S157-S157
Author(s):  
G T Kennedy ◽  
R Stone II ◽  
A C Kowalczweski ◽  
R Rowland ◽  
J H Chen ◽  
...  
Keyword(s):  
Spatial Frequency ◽  
Frequency Domain ◽  
Skin Graft ◽  
Porcine Model ◽  
Burn Wound ◽  
Spatial Frequency Domain Imaging ◽  
In Vivo Characterization ◽  
Spatial Frequency Domain

scholarly journals Wide-field quantitative imaging of tissue microstructure using sub-diffuse spatial frequency domain imaging

Optica ◽  
2016 ◽  
Vol 3 (6) ◽  
pp. 613 ◽  
Author(s):  
David M. McClatchy ◽  
Elizabeth J. Rizzo ◽  
Wendy A. Wells ◽  
Philip P. Cheney ◽  
Jeeseong C. Hwang ◽  
...  
Keyword(s):  
Spatial Frequency ◽  
Frequency Domain ◽  
Quantitative Imaging ◽  
Wide Field ◽  
Tissue Microstructure ◽  
Spatial Frequency Domain Imaging ◽  
Spatial Frequency Domain

scholarly journals Spatial frequency domain imaging: a quantitative, noninvasive tool for in vivo monitoring of burn wound and skin graft healing

2019 ◽  
Vol 24 (07) ◽  
pp. 1 ◽  
Author(s):  
Gordon T. Kennedy ◽  
Randolph Stone ◽  
Andrew C. Kowalczewski ◽  
Rebecca Rowland ◽  
Jeffrey H. Chen ◽  
...  
Keyword(s):  
Spatial Frequency ◽  
Frequency Domain ◽  
Skin Graft ◽  
Burn Wound ◽  
In Vivo Monitoring ◽  
Graft Healing ◽  
Spatial Frequency Domain Imaging ◽  
Spatial Frequency Domain

scholarly journals Halftone spatial frequency domain imaging enables kilohertz high-speed label-free non-contact quantitative mapping of optical properties for strongly turbid media

2021 ◽  
Vol 10 (1) ◽  
Author(s):  
Yanyu Zhao ◽  
Bowen Song ◽  
Ming Wang ◽  
Yang Zhao ◽  
Yubo Fan
Keyword(s):  
Optical Properties ◽  
Spatial Frequency ◽  
Frequency Domain ◽  
High Speed ◽  
Turbid Media ◽  
Wide Field ◽  
Label Free ◽  
Spatial Frequency Domain Imaging ◽  
Spatial Frequency Domain

AbstractThe ability to quantify optical properties (i.e., absorption and scattering) of strongly turbid media has major implications on the characterization of biological tissues, fluid fields, and many others. However, there are few methods that can provide wide-field quantification of optical properties, and none is able to perform quantitative optical property imaging with high-speed (e.g., kilohertz) capabilities. Here we develop a new imaging modality termed halftone spatial frequency domain imaging (halftone-SFDI), which is approximately two orders of magnitude faster than the state-of-the-art, and provides kilohertz high-speed, label-free, non-contact, wide-field quantification for the optical properties of strongly turbid media. This method utilizes halftone binary patterned illumination to target the spatial frequency response of turbid media, which is then mapped to optical properties using model-based analysis. We validate the halftone-SFDI on an array of phantoms with a wide range of optical properties as well as in vivo human tissue. We demonstrate with an in vivo rat brain cortex imaging study, and show that halftone-SFDI can longitudinally monitor the absolute concentration as well as spatial distribution of functional chromophores in tissue. We also show that halftone-SFDI can spatially map dual-wavelength optical properties of a highly dynamic flow field at kilohertz speed. Together, these results highlight the potential of halftone-SFDI to enable new capabilities in fundamental research and translational studies including brain science and fluid dynamics.

scholarly journals Preclinical evaluation of spatial frequency domain-enabled wide-field quantitative imaging for enhanced glioma resection

2017 ◽  
Vol 22 (7) ◽  
pp. 076007 ◽  
Author(s):  
Mira Sibai ◽  
Carl Fisher ◽  
Israel Veilleux ◽  
Jonathan T. Elliott ◽  
Frederic Leblond ◽  
...  
Keyword(s):  
Spatial Frequency ◽  
Frequency Domain ◽  
Quantitative Imaging ◽  
Wide Field ◽  
Preclinical Evaluation ◽  
Glioma Resection ◽  
Spatial Frequency Domain
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