scholarly journals Real-time in vivo diagnosis of laryngeal carcinoma with rapid fiber-optic Raman spectroscopy

2016 ◽  
Vol 7 (9) ◽  
pp. 3705 ◽  
Author(s):  
Kan Lin ◽  
Wei Zheng ◽  
Chwee Ming Lim ◽  
Zhiwei Huang
Keyword(s):  
Raman Spectroscopy ◽  
Real Time ◽  
Laryngeal Carcinoma ◽  
Fiber Optic ◽  
In Vivo Diagnosis

scholarly journals Real-time In vivo Diagnosis of Nasopharyngeal Carcinoma Using Rapid Fiber-Optic Raman Spectroscopy

Theranostics ◽  
2017 ◽  
Vol 7 (14) ◽  
pp. 3517-3526 ◽  
Author(s):  
Kan Lin ◽  
Wei Zheng ◽  
Chwee Ming Lim ◽  
Zhiwei Huang
Keyword(s):  
Raman Spectroscopy ◽  
Nasopharyngeal Carcinoma ◽  
Real Time ◽  
Fiber Optic ◽  
In Vivo Diagnosis

Sa1831 Image-Guided Raman Spectroscopy for Real-Time In Vivo Diagnosis of Barrett's Esophagus During Endoscopic Examination

2012 ◽  
Vol 142 (5) ◽  
pp. S-336 ◽  
Author(s):  
Mads Sylvest Bergholt ◽  
Wei Zheng ◽  
Khek-Yu Ho ◽  
Ming Teh ◽  
Khay Guan Yeoh ◽  
...  
Keyword(s):  
Raman Spectroscopy ◽  
Real Time ◽  
Barrett’S Esophagus ◽  
Barrett's Esophagus ◽  
Endoscopic Examination ◽  
Image Guided ◽  
In Vivo Diagnosis

Fiberoptic Confocal Raman Spectroscopy for Real-Time In Vivo Diagnosis of Dysplasia in Barrett's Esophagus

2014 ◽  
Vol 146 (1) ◽  
pp. 27-32 ◽  
Author(s):  
Mads Sylvest Bergholt ◽  
Wei Zheng ◽  
Khek Yu Ho ◽  
Ming Teh ◽  
Khay Guan Yeoh ◽  
...  
Keyword(s):  
Raman Spectroscopy ◽  
Real Time ◽  
Barrett’S Esophagus ◽  
Barrett's Esophagus ◽  
Confocal Raman Spectroscopy ◽  
Confocal Raman ◽  
In Vivo Diagnosis

Fiber-optic Raman spectroscopy for in vivo diagnosis of gastric dysplasia

2016 ◽  
Vol 187 ◽  
pp. 377-392 ◽  
Author(s):  
Jianfeng Wang ◽  
Kan Lin ◽  
Wei Zheng ◽  
Khek Yu Ho ◽  
Ming Teh ◽  
...  
Keyword(s):  
Raman Spectroscopy ◽  
Real Time ◽  
Raman Spectra ◽  
Fiber Optic ◽  
Endoscopic Examination ◽  
Great Promise ◽  
Gastric Tissue ◽  
Spectroscopy Technique ◽  
Gastric Dysplasia

This study aims to assess the clinical utility of a rapid fiber-optic Raman spectroscopy technique developed for enhancingin vivodiagnosis of gastric precancer during endoscopic examination. We have developed a real-time fiber-optic Raman spectroscopy system capable of simultaneously acquiring both fingerprint (FP) (i.e., 800–1800 cm−1) and high-wavenumber (HW) (i.e., 2800–3600 cm−1) Raman spectra from gastric tissuein vivoat endoscopy. A total of 5792 high-qualityin vivoFP/HW Raman spectra (normal (n= 5160); dysplasia (n= 155), and adenocarcinoma (n= 477)) were acquired in real-time from 441 tissue sites (normal (n= 396); dysplasia (n= 11), and adenocarcinoma (n= 34)) of 191 gastric patients (normal (n= 172); dysplasia (n= 6), and adenocarcinoma (n= 13)) undergoing routine endoscopic examinations. Partial least squares discriminant analysis (PLS-DA) together with leave-one-patient-out cross validation (LOPCV) were implemented to develop robust spectral diagnostic models. The FP/HW Raman spectra differ significantly between normal, dysplasia and adenocarcinoma of the stomach, which can be attributed to changes in proteins, lipids, nucleic acids, and the bound water content. PLS-DA and LOPCV show that the fiber-optic FP/HW Raman spectroscopy provides diagnostic sensitivities of 96.0%, 81.8% and 88.2%, and specificities of 86.7%, 95.3% and 95.6%, respectively, for the classification of normal, dysplastic and cancerous gastric tissue, superior to either the FP or HW Raman techniques alone. Further dichotomous PLS-DA analysis yields a sensitivity of 90.9% (10/11) and specificity of 95.9% (380/396) for the detection of gastric dysplasia using FP/HW Raman spectroscopy, substantiating its clinical advantages over white light reflectance endoscopy (sensitivity: 90.9% (10/11), and specificity: 51.0% (202/396)). This work demonstrates that the fiber-optic FP/HW Raman spectroscopy technique has great promise for enhancingin vivodiagnosis of gastric precancer during routine endoscopic examination.

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