scholarly journals Numerical modeling of light propagation in biological tissues: time-resolved 3D simulations based on light diffusion model and FDTD solution of Maxwell's equations

2011 ◽  
Author(s):  
N. Ortega-Quijano ◽  
O. G. Romanov ◽  
F. Fanjul-Vélez ◽  
I. Salas-García ◽  
A. L. Tolstik ◽  
...  
Keyword(s):  
Numerical Modeling ◽  
Diffusion Model ◽  
Maxwell’S Equations ◽  
Maxwell's Equations ◽  
Light Propagation ◽  
Biological Tissues ◽  
Time Resolved ◽  
3D Simulations ◽  
Light Diffusion

Analysis of Ultrafast Laser Propagation in Biological Tissues With Embedded Tumors and Large Blood Vessels

2006 ◽  
Author(s):  
Jianhua Zhou ◽  
Yuwen Zhang ◽  
J. K. Chen
Keyword(s):  
Refractive Index ◽  
Blood Vessels ◽  
Light Propagation ◽  
Monte Carlo Model ◽  
Biological Tissues ◽  
Propagation Path ◽  
Direct Result ◽  
Time Resolved ◽  
Laser Propagation ◽  
Foreign Objects

Time-resolved optical imaging technique offers the promise for development of safe, noninvasive, and inexpensive clinical imaging modalities with diagnostic ability. However, the presence of mismatched refractive-index boundaries in a soft tissue will tremendously change light propagation path, which in turn, makes the optical image obscure if not indiscernible. In this article, a time-resolved Monte Carlo model, which takes into account the photon reflection/transmission behavior at the mismatched refractive-index boundaries, is developed to investigate transient light propagation in biological tissues with embedded tumors and blood vessels. The results show that the temporal reflection signal displays two peak values when refractive-index mismatched foreign objects, such as tumors or blood vessels, are embedded in the tissue. One peak is a direct result arising from the pulse nature of the incident laser light, and the other is due to the backscattering from the refractive-index mismatched boundaries. This suggests that the occurrence of the "second peak" be an indication for the location and size of tumors inside the tissue.

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