Deep-tissue Fluorescence Imaging using Ultrasound-encoded Digitally Time-reversed Light

2012 ◽  
Author(s):  
Ying Min Wang ◽  
Benjamin Judkewitz ◽  
Charles A. DiMarzio ◽  
Changhuei Yang
Keyword(s):  
Fluorescence Imaging ◽  
Deep Tissue ◽  
Tissue Fluorescence

scholarly journals 3D Tissue Reconstruction by using Deep Tissue Fluorescence Imaging System and FLIM

2014 ◽  
Vol 106 (2) ◽  
pp. 400a
Author(s):  
Sohail Jahid ◽  
Alexander S. Dvornikov ◽  
Michelle Digman ◽  
Enrico Gratton
Keyword(s):  
Fluorescence Imaging ◽  
Imaging System ◽  
Deep Tissue ◽  
Tissue Reconstruction ◽  
Fluorescence Imaging System ◽  
Tissue Fluorescence

scholarly journals Deep tissue fluorescence imaging andin vivobiological applications

2012 ◽  
Vol 17 (11) ◽  
pp. 116023 ◽  
Author(s):  
Viera Crosignani ◽  
Alexander Dvornikov ◽  
Jose S Aguilar ◽  
Chiara Stringari ◽  
Robert Edwards ◽  
...  
Keyword(s):  
Fluorescence Imaging ◽  
Deep Tissue ◽  
Tissue Fluorescence

scholarly journals Numerical Simulation of a Scanning Illumination System for Deep Tissue Fluorescence Imaging

2019 ◽  
Vol 5 (11) ◽  
pp. 83
Author(s):  
Qimei Zhang ◽  
Anna M. Grabowska ◽  
Philip A. Clarke ◽  
Stephen P. Morgan
Keyword(s):  
Fluorescence Imaging ◽  
Spatial Resolution ◽  
Near Infrared ◽  
Scanning System ◽  
Deep Tissue ◽  
Full Field ◽  
Infrared Wavelength ◽  
Tissue Optical Properties ◽  
Illumination System ◽  
Tissue Fluorescence

The spatial resolution and light detected in fluorescence imaging for small animals are limited by light scattering, absorption and autofluorescence. To address this, novel near-infrared fluorescent contrast agents and imaging configurations have been investigated. In this paper, the influence of the light wavelength and imaging configurations (full-field illumination system and scanning system) on fluorescence imaging are compared quantitatively. The surface radiance for both systems is calculated by modifying the simulation tool Near-Infrared Fluorescence and Spectral Tomography. Fluorescent targets are embedded within a scattering medium at different positions. The surface radiance and spatial resolution are obtained for emission wavelengths between 620 nm and 1000 nm. It was found that the spatial resolution of the scanning system is independent of the tissue optical properties, whereas for full-field illumination, the spatial resolution degrades at longer wavelength. The full width at half maximum obtained by the scanning system is 25% lower than that obtained by the full-field illumination system when the targets are located in the middle of the phantom. The results indicate that although imaging at near-infrared wavelength can achieve a higher surface radiance, it may produce worse spatial resolution.

scholarly journals Bi2O3 boosts Brightness, Biocompatibility and Stability of Mn-doped Ba3(VO4)2 as NIR-II Contrast Agent

2021 ◽  
Author(s):  
Pascal Gschwend ◽  
Kerda Keevend ◽  
Marianne Aellen ◽  
Alexander Gogos ◽  
Frank Krumeich ◽  
...  
Keyword(s):  
Contrast Agent ◽  
Contrast Agents ◽  
Fluorescence Imaging ◽  
Chemical Stability ◽  
Biocompatible Materials ◽  
Deep Tissue ◽  
Limited Availability ◽  
Tissue Fluorescence ◽  
Mn Doped

Deep-tissue fluorescence imaging remains a major challenge as there is limited availability of bright biocompatible materials with high photo- and chemical stability. Contrast agents with emission wavelengths above 1000 nm...

scholarly journals A deep tissue fluorescence imaging system with enhanced SHG detection capabilities

2014 ◽  
Vol 77 (5) ◽  
pp. 368-373 ◽  
Author(s):  
Viera Crosignani ◽  
Sohail Jahid ◽  
Alexander S. Dvornikov ◽  
Enrico Gratton
Keyword(s):  
Fluorescence Imaging ◽  
Imaging System ◽  
Deep Tissue ◽  
Fluorescence Imaging System ◽  
Tissue Fluorescence ◽  
Detection Capabilities

Deep tissue fluorescence imaging using time-reversed light

2012 ◽  
Vol 18 (S2) ◽  
pp. 1218-1219
Author(s):  
Y.M. Wang ◽  
B. Judkewitz ◽  
C. Yang ◽  
M. Cui ◽  
C. DiMarzio
Keyword(s):  
Fluorescence Imaging ◽  
Deep Tissue ◽  
Tissue Fluorescence

Extended abstract of a paper presented at Microscopy and Microanalysis 2012 in Phoenix, Arizona, USA, July 29 – August 2, 2012.

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