scholarly journals Functional Analysis of the Cathepsin-Like Cysteine Protease Genes in Adult Brugia malayi Using RNA Interference

2009 ◽  
Vol 3 (2) ◽  
pp. e377 ◽  
Author(s):  
Louise Ford ◽  
Jun Zhang ◽  
Jing Liu ◽  
Sarwar Hashmi ◽  
Juliet A. Fuhrman ◽  
...  
Keyword(s):  
Functional Analysis ◽  
Rna Interference ◽  
Cysteine Protease ◽  
Brugia Malayi

scholarly journals Functional analysis of microRNA activity in Brugia malayi

2015 ◽  
Vol 45 (9-10) ◽  
pp. 579-583 ◽  
Author(s):  
Canhui Liu ◽  
Denis Voronin ◽  
Catherine B. Poole ◽  
Saheed Bachu ◽  
Matthew B. Rogers ◽  
...  
Keyword(s):  
Functional Analysis ◽  
Brugia Malayi

Functional analysis of cholesterol biosynthesis by RNA interference

2007 ◽  
Vol 104 (3-5) ◽  
pp. 105-109 ◽  
Author(s):  
Christina Guggenberger ◽  
Denise Ilgen ◽  
Jerzy Adamski
Keyword(s):  
Functional Analysis ◽  
Rna Interference ◽  
Cholesterol Biosynthesis

scholarly journals Structure-Function of Falcipains: Malarial Cysteine Proteases

2012 ◽  
Vol 2012 ◽  
pp. 1-11 ◽  
Author(s):  
Kailash C. Pandey ◽  
Rajnikant Dixit
Keyword(s):  
Functional Analysis ◽  
Drug Development ◽  
Protease Inhibitors ◽  
Cysteine Protease ◽  
Essential Role ◽  
Cysteine Proteases ◽  
Structural Studies ◽  
Cysteine Protease Inhibitors ◽  
Hemoglobin Binding ◽  
Structural Insight

Evidence indicates that cysteine proteases play essential role in malaria parasites; therefore an obvious area of investigation is the inhibition of these enzymes to treat malaria. Studies with cysteine protease inhibitors and manipulating cysteine proteases genes have suggested a role for cysteine proteases in hemoglobin hydrolysis. The best characterizedPlasmodiumcysteine proteases are falcipains, which are papain family enzymes. Falcipain-2 and falcipain-3 are major hemoglobinases ofP. falciparum. Structural and functional analysis of falcipains showed that they have unique domains including a refolding domain and a hemoglobin binding domain. Overall, the complexes of falcipain-2 and falcipain-3 with small and macromolecular inhibitors provide structural insight to facilitate the design or modification of effective drug treatment against malaria. Drug development targeting falcipains should be aided by a strong foundation of biochemical and structural studies.

scholarly journals Functional analysis of a novel parasitic nematode-specific protein of Setaria digitata larvae in Culex quinquefasciatus by siRNA mediated RNA interference

2018 ◽  
Vol 11 (1) ◽  
Author(s):  
Magalla Bastian Chalitha Lakmal Somarathne ◽  
Yasanthi Illika Nilmini Silva Gunawardene ◽  
Naduvilath Vishvanath Chandrasekharan ◽  
Arjuna Nisantha Bandara Ellepola ◽  
Ranil Samantha Dassanayake
Keyword(s):  
Functional Analysis ◽  
Rna Interference ◽  
Culex Quinquefasciatus ◽  
Parasitic Nematode ◽  
Specific Protein ◽  
Setaria Digitata

FUNCTIONAL ANALYSIS OF NKX3.1 BY RNA INTERFERENCE IN LNCAP PROSTATE CANCER CELLS

2008 ◽  
Vol 7 (3) ◽  
pp. 173
Author(s):  
M. Possner ◽  
S. Kaulfuss ◽  
A. Strauss ◽  
W. Schulz ◽  
R.H. Ringert ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Functional Analysis ◽  
Rna Interference ◽  
Cancer Cells ◽  
Prostate Cancer Cells

scholarly journals Femcoat, a novel eggshell protein in Drosophila: functional analysis by double stranded RNA interference

2002 ◽  
Vol 110 (1-2) ◽  
pp. 61-70 ◽  
Author(s):  
Chun Kim ◽  
Kyulee Han ◽  
Juri Kim ◽  
Jin Soo Yi ◽  
Changsoo Kim ◽  
...  
Keyword(s):  
Functional Analysis ◽  
Rna Interference ◽  
Double Stranded Rna
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