scholarly journals Leishmania major Infection in Humanized Mice Induces Systemic Infection and Provokes a Nonprotective Human Immune Response

2012 ◽  
Vol 6 (7) ◽  
pp. e1741 ◽  
Author(s):  
Anja Kathrin Wege ◽  
Christian Florian ◽  
Wolfgang Ernst ◽  
Nicole Zimara ◽  
Ulrike Schleicher ◽  
...  
2008 ◽  
Vol 22 (S2) ◽  
pp. 422-422
Author(s):  
Daisy Vanitha John ◽  
Laura Crisa ◽  
Gabrielle Cauvi ◽  
Mohey Eldin El Shikh ◽  
John G Tew ◽  
...  

2015 ◽  
Vol 212 (3) ◽  
pp. 435-444 ◽  
Author(s):  
Janin Knop ◽  
Frank Hanses ◽  
Teresa Leist ◽  
Nancie M. Archin ◽  
Stefan Buchholz ◽  
...  

2021 ◽  
Vol 27 (4) ◽  
pp. 571-572 ◽  
Author(s):  
Roberto Burioni ◽  
Eric J. Topol

2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
Diane Williamson

This review considers the steps required to evaluate a candidate biodefense vaccine or therapy as it emerges from the research phase, in order to transition it to development. The options for preclinical modelling of efficacy are considered in the context of the FDA’s Animal Rule.


1989 ◽  
Vol 21 (4) ◽  
pp. 386???392 ◽  
Author(s):  
LEONARD H. CALABRESE ◽  
SUSAN M. KLEINER ◽  
BARBARA P. BARNA ◽  
CHRISTINE I. SKIBINSKI ◽  
DONALD T. KIRKENDALL ◽  
...  

2007 ◽  
Vol 1004 ◽  
Author(s):  
David B. Fenner ◽  
David I Rosen ◽  
Anthony A Ferrante ◽  
Amy E Stevens ◽  
Chad E Bigelow ◽  
...  

AbstractDevelopment of field portable apparatus and methods for cytokine assay of human saliva by fluorescent-reporting microarray plates is described. Multiplexed assay of 12 cytokines for minimally-processed saliva is read with a CCD-based imager under LED excitation. Immune responsive cytokines are measured at levels significant for indication of human disease state. The motivational context for the new apparatus development, the general optical design issues, saliva protocol, and image analysis are described.


Hybridoma ◽  
1999 ◽  
Vol 18 (2) ◽  
pp. 121-129 ◽  
Author(s):  
WENDY A. HUTCHINS ◽  
THOMAS KIEBER-EMMONS ◽  
GEORGE M. CARLONE ◽  
M.A. JULIE WESTERINK

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