scholarly journals Gastrointestinal-Sparing Effects of Novel NSAIDs in Rats with Compromised Mucosal Defence

PLoS ONE ◽  
2012 ◽  
Vol 7 (4) ◽  
pp. e35196 ◽  
Author(s):  
Rory Blackler ◽  
Stephanie Syer ◽  
Manlio Bolla ◽  
Ennio Ongini ◽  
John L. Wallace
Keyword(s):  
Mucosal Defence

Transepithelial transport and mucosal defence I: the role of M cells

1992 ◽  
Vol 2 (5) ◽  
pp. 134-138 ◽  
Author(s):  
Marian R. Neutra ◽  
Jean-Pierre Kraehenbuhl
Keyword(s):  
Transepithelial Transport ◽  
M Cells ◽  
Mucosal Defence

Intestinal mast cell response and mucosal defence against Strongyloides venezuelensis in interleukin-3-hyporesponsive mice

2002 ◽  
Vol 20 (6) ◽  
pp. 279-284 ◽  
Author(s):  
KOBAYASHI ◽  
TSUCHIYA ◽  
HARA ◽  
NAKAHATA ◽  
KUROKAWA ◽  
...  
Keyword(s):  
Mast Cell ◽  
Cell Response ◽  
Interleukin 3 ◽  
Strongyloides Venezuelensis ◽  
Mucosal Defence

scholarly journals Nitric oxide as a mediator of gastrointestinal mucosal injury?—Say it ain't so

1995 ◽  
Vol 4 (6) ◽  
pp. 397-405 ◽  
Author(s):  
Paul Kubes ◽  
John L. Wallace
Keyword(s):  
Nitric Oxide ◽  
Gastrointestinal Tract ◽  
Inflammatory Responses ◽  
Tissue Injury ◽  
Mucosal Blood Flow ◽  
Mucosal Injury ◽  
Experimental Models ◽  
Radical Species ◽  
Overwhelming Evidence ◽  
Mucosal Defence

Nitric oxide has been suggested as a contributor to tissue injury in various experimental models of gastrointestinal inflammation. However, there is overwhelming evidence that nitric oxide is one of the most important mediators of mucosal defence, influencing such factors as mucus secretion, mucosal blood flow, ulcer repair and the activity of a variety of mucosal immunocytes. Nitric oxide has the capacity to down-regulate inflammatory responses in the gastrointestinal tract, to scavenge various free radical species and to protect the mucosa from injury induced by topical irritants. Moreover, questions can be raised regarding the evidence purported to support a role for nitric oxide in producing tissue injury. In this review, we provide an overview of the evidence supporting a role for nitric oxide in protecting the gastrointestinal tract from injury.

Regulating factors affecting gut mucosal defence

1994 ◽  
pp. 48-75
Author(s):  
D. M. McKay ◽  
V. J. Djuric ◽  
M. H. Perdue ◽  
J. Bienenstock
Keyword(s):  
Factors Affecting ◽  
Mucosal Defence

Characterisation of α2-adrenoceptor subtypes involved in gastric emptying, gastric motility and gastric mucosal defence

2005 ◽  
Vol 528 (1-3) ◽  
pp. 150-157 ◽  
Author(s):  
Katalin Fülöp ◽  
Zoltán Zádori ◽  
András Z. Rónai ◽  
Klára Gyires
Keyword(s):  
Gastric Emptying ◽  
Gastric Motility ◽  
Α2 Adrenoceptor ◽  
Mucosal Defence

Effects of estrogen-deficiency on gastric mucosal defence and nitric oxide synthase activity

2000 ◽  
Vol 118 (4) ◽  
pp. A1279
Author(s):  
Eva Morschl ◽  
Ildiko Bretus ◽  
Lajos Topa ◽  
Zsoka Weiszhar ◽  
Ferenc Laszlo
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Estrogen Deficiency ◽  
Oxide Synthase ◽  
Nitric Oxide Synthase Activity ◽  
Mucosal Defence

The C5a chemoattractant receptor mediates mucosal defence to infection

Nature ◽  
1996 ◽  
Vol 383 (6595) ◽  
pp. 86-89 ◽  
Author(s):  
Uta E. Höpken ◽  
Bao Lu ◽  
Norma P. Gerard ◽  
Craig Gerard
Keyword(s):  
Mucosal Defence
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