scholarly journals Prepulse Inhibition of Acoustic Startle Reflex as a Function of the Frequency Difference between Prepulse and Background Sounds in Mice

PLoS ONE ◽  
2012 ◽  
Vol 7 (9) ◽  
pp. e45123 ◽  
Author(s):  
Sidhesh Basavaraj ◽  
Jun Yan
Keyword(s):  
Prepulse Inhibition ◽  
Acoustic Startle ◽  
Startle Reflex ◽  
Acoustic Startle Reflex ◽  
Frequency Difference

Roles of the glutamate receptor ε2 and δ2 subunits in the potentiation and prepulse inhibition of the acoustic startle reflex

2001 ◽  
Vol 14 (1) ◽  
pp. 153-160 ◽  
Author(s):  
Tomonori Takeuchi ◽  
Yuji Kiyama ◽  
Kazuhiro Nakamura ◽  
Mika Tsujita ◽  
Ikuo Matsuda ◽  
...  
Keyword(s):  
Prepulse Inhibition ◽  
Glutamate Receptor ◽  
Acoustic Startle ◽  
Startle Reflex ◽  
Acoustic Startle Reflex

scholarly journals Prepulse Inhibition of the Acoustic Startle Reflex in High Functioning Autism

PLoS ONE ◽  
2014 ◽  
Vol 9 (3) ◽  
pp. e92372 ◽  
Author(s):  
Sina Kohl ◽  
Carolin Wolters ◽  
Theo O. J. Gruendler ◽  
Kai Vogeley ◽  
Joachim Klosterkötter ◽  
...  
Keyword(s):  
Prepulse Inhibition ◽  
High Functioning Autism ◽  
Acoustic Startle ◽  
Startle Reflex ◽  
Acoustic Startle Reflex ◽  
High Functioning

Prepulse inhibition of the acoustic startle reflex in pigs and its disruption by d-amphetamine

2004 ◽  
Vol 155 (2) ◽  
pp. 217-222 ◽  
Author(s):  
Nanna M. Lind ◽  
Sidse M. Arnfred ◽  
Ralf P. Hemmingsen ◽  
Axel K. Hansen
Keyword(s):  
Prepulse Inhibition ◽  
Acoustic Startle ◽  
Startle Reflex ◽  
Acoustic Startle Reflex

scholarly journals  Life-Course Contribution of Prenatal Stress in Regulating the Neural Modulation Network Underlying the Prepulse Inhibition of the Acoustic Startle Reflex in Male Alzheimer’s Disease Mice

2019 ◽  
Vol 30 (1) ◽  
pp. 311-325 ◽  
Author(s):  
Zahra Jafari ◽  
Bryan E Kolb ◽  
Majid H Mohajerani
Keyword(s):  
Prepulse Inhibition ◽  
Hpa Axis ◽  
Prenatal Stress ◽  
Acoustic Startle ◽  
Sensorimotor Gating ◽  
Startle Reflex ◽  
Underlying Mechanism ◽  
Acoustic Startle Reflex ◽  
Abnormal Development ◽  
Brain Areas

Abstract The prepulse inhibition (PPI) of the acoustic startle reflex (ASR), as an index of sensorimotor gating, is one of the most extensively used paradigms in the field of neuropsychiatric disorders. Few studies have examined how prenatal stress (PS) regulates the sensorimotor gating during the lifespan and how PS modifies the development of amyloid-beta (Aβ) pathology in brain areas underlying the PPI formation. We followed alternations in corticosterone levels, learning and memory, and the PPI of the ASR measures in APPNL-G-F/NL-G-F offspring of dams exposed to gestational noise stress. In-depth quantifications of the Aβ plaque accumulation were also performed at 6 months. The results indicated an age-dependent deterioration of sensorimotor gating, long-lasting PS-induced abnormalities in PPI magnitudes, as well as deficits in spatial memory. The PS also resulted in a higher Aβ aggregation predominantly in brain areas associated with the PPI modulation network. The findings suggest the contribution of a PS-induced hypothalamic-pituitary-adrenal (HPA) axis hyperactivity in regulating the PPI modulation substrates leading to the abnormal development of the neural protection system in response to disruptive stimuli. The long-lasting HPA axis dysregulation appears to be the major underlying mechanism in precipitating the Aβ deposition, especially in brain areas contributed to the PPI modulation network.

Personality Correlates of Prepulse Inhibition of the Startle Reflex at Three Lead Intervals

2002 ◽  
Vol 16 (2) ◽  
pp. 82-91 ◽  
Author(s):  
Philip J. Corr ◽  
Allison Tynan ◽  
Veena Kumari
Keyword(s):  
Prepulse Inhibition ◽  
Acoustic Startle ◽  
Sensorimotor Gating ◽  
Startle Reflex ◽  
Incentive Motivation ◽  
Acoustic Startle Reflex ◽  
Pulse Interval ◽  
Causal Explanations ◽  
Psychosis Proneness ◽  
Psychometric Measures

Abstract The acoustic startle reflex (ASR) is modulated by a number of experimental factors, the most important of which in the field of psychopathology is weak prestimulation: The ASR is reliably reduced if preceded briefly by a weaker stimulus (i. e., the prepulse), an effect known as prepulse inhibition (PPI). PPI is thought to reflect centrally-mediated sensorimotor gating of stimuli, preventing cognitive overload and behavioural confusion. PPI is impaired in a variety of psychiatric disorders, notably schizophrenia, as well as in individuals who score high on psychometric measures of psychosis proneness. Two experiments examined the association of personality (trait emotionality) and PPI at three prepulse-to-pulse intervals (30, 60 and 120 ms). Consistent with previous reports, findings from both experiments showed highly significant PPI (defined as percentage reduction in the amplitude of the ASR), which increased with prepulse-to-pulse interval (30 < 60 < 120 ms). A novel finding was that, in both experiments 1 (N = 36) and 2 (N = 63), the trait of neuroticism was negatively correlated with PPI; in addition, a measure of positive incentive motivation (i. e., Behavioural Activation System, Drive subscale; BAS-Drive) was also negatively correlated with PPI. These trait emotionality associations were independent of gender. Possible causal explanations of these personality associations are outlined. It is concluded that, in order to clarify the aetiological role of sensorimotor gating in psychopathological conditions (e. g., schizophrenia, often entailing emotional activation), trait emotionality variance should be routinely examined in future PPI studies.

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