scholarly journals Fibroblast Growth Factor 21 (FGF21) Protects against High Fat Diet Induced Inflammation and Islet Hyperplasia in Pancreas

PLoS ONE ◽  
2016 ◽  
Vol 11 (2) ◽  
pp. e0148252 ◽  
Author(s):  
Garima Singhal ◽  
ffolliott Martin Fisher ◽  
Melissa J. Chee ◽  
Tze Guan Tan ◽  
Abdelfattah El Ouaamari ◽  
...  
Keyword(s):  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
High Fat Diet ◽  
Fibroblast Growth Factor 21 ◽  
Fibroblast Growth ◽  
High Fat ◽  
Islet Hyperplasia

Effect of vanillic acid and exercise training on fatty liver and insulin resistance in rats: Possible role of fibroblast growth factor 21 and autophagy

2021 ◽  
Keyword(s):  
Growth Factor ◽  
Fatty Liver ◽  
Fibroblast Growth Factor ◽  
Vanillic Acid ◽  
High Fat Diet ◽  
Male Rats ◽  
Swimming Exercise ◽  
Fibroblast Growth Factor 21 ◽  
Fibroblast Growth ◽  
High Fat

Abstract Background and aims The prevalence of non-alcoholic fatty liver disease has been alarmingly increased with no lines of effective treatment. Vanillic acid is a naturally occurring polyphenol with promising therapeutic effects. Exercise is well known to be an effective tool against obesity and its consequences. Thus, we aim to study the effect of vanillic acid alone and along with exercise on fatty liver induced by a high-fat diet in a rat model and to investigate possible novel mechanisms involved in their action. Methods In this study, 40 male rats were divided equally into five groups: control (standard chow diet), HFD (high-fat diet), HFD+VA (HFD+ vanillic acid (50 mg/kg/day orally), HFD+EX (HFD+ swimming exercise 5 days/week), HFD+VA+EX (HFD+ vanillic acid+ swimming exercise) for eight weeks. Results Body mass, liver weight, liver enzymes, cholesterol, and triglycerides were significantly decreased in the combined VA+EX group, with marked improvement in hyperglycemia, hyperinsulinemia, and consequently HOMA-IR index compared to the HFD group. These improvements were also reflected in the pathological view. VA and swimming, either solely or in combination, markedly increased hepatic and circulating fibroblast growth factor 21. Additionally, VA and swimming increased the immunohistochemical expression of the autophagosomal marker LC3 and decreased the expression of P62, which is selectively degraded during autophagy. Conclusions These results suggest the hepatoprotective effect of VA and swimming exercise against fatty liver and the involvement of FGF21 and autophagy in their effect.

Long-term high-fat diet links the regulation of the insulin-sensitizing fibroblast growth factor-21 and visfatin

Cytokine ◽  
2012 ◽  
Vol 59 (1) ◽  
pp. 131-137 ◽  
Author(s):  
Bin Sun ◽  
Gangyi Yang ◽  
Mengliu Yang ◽  
Hua Liu ◽  
Guenther Boden ◽  
...  
Keyword(s):  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
High Fat Diet ◽  
Fibroblast Growth Factor 21 ◽  
Fibroblast Growth ◽  
High Fat

scholarly journals Increased plasma FGF21 level as an early biomarker for insulin resistance and metabolic disturbance in obese insulin-resistant rats

2018 ◽  
Vol 15 (3) ◽  
pp. 263-269 ◽  
Author(s):  
Pongpan Tanajak ◽  
Wanpitak Pongkan ◽  
Siriporn C Chattipakorn ◽  
Nipon Chattipakorn
Keyword(s):  
Insulin Resistance ◽  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
High Fat Diet ◽  
Density Lipoprotein ◽  
Cardiac Fibroblast ◽  
Normal Diet ◽  
Fibroblast Growth Factor 21 ◽  
Fibroblast Growth ◽  
High Fat

Propose: To investigate the temporal relationship between plasma fibroblast growth factor 21 levels, insulin resistance, metabolic dysfunction and cardiac fibroblast growth factor 21 resistance in long-term high-fat diet–induced obese rats. Methods: In total, 36 male Wistar rats were fed with either a normal diet or high-fat diet for 12 weeks. Blood was collected from the tail tip, and plasma was used to determine metabolic profiles and fibroblast growth factor 21 levels. Rats were sacrificed at weeks 4, 8 and 12, and the hearts were rapidly removed for the determination of cardiac fibroblast growth factor 21 signalling pathways. Results: Body weight and plasma fibroblast growth factor 21 levels were increased after 4 weeks of consumption of a high-fat diet. At weeks 8 and 12, high-fat diet rats had significantly increased body weight and plasma fibroblast growth factor 21 levels, together with increased plasma insulin, HOMA index, area under the curve of glucose, plasma total cholesterol, plasma low-density lipoprotein cholesterol, serum malondialdehyde and cardiac malondialdehyde levels. However, plasma high-density lipoprotein cholesterol levels and cardiac fibroblast growth factor 21 signalling proteins (p-FGFR1 Tyr154, p-ERK1/2 Thr202/Tyr204 and p-Akt Ser473) were decreased, compared with normal diet rats. Conclusion: These findings suggest that plasma fibroblast growth factor 21 levels could be an early predictive biomarker prior to the development of insulin resistance, metabolic disturbance and cardiac fibroblast growth factor 21 resistance.

scholarly journals Phosphorus restriction does not prevent the increase in fibroblast growth factor 23 elicited by high fat diet

PLoS ONE ◽  
2018 ◽  
Vol 13 (6) ◽  
pp. e0198481 ◽  
Author(s):  
Rafael Rios ◽  
Carmen Pineda ◽  
Ignacio Lopez ◽  
Juan Muñoz-Castañeda ◽  
Mariano Rodriguez ◽  
...  
Keyword(s):  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
High Fat Diet ◽  
Fibroblast Growth Factor 23 ◽  
Fibroblast Growth ◽  
High Fat

scholarly journals Fibroblast growth factor 21 is required for beneficial effects of exercise during chronic high-fat feeding

2016 ◽  
Vol 121 (3) ◽  
pp. 687-698 ◽  
Author(s):  
Christine Loyd ◽  
I. Jack Magrisso ◽  
Michael Haas ◽  
Sowmya Balusu ◽  
Radha Krishna ◽  
...  
Keyword(s):  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Metabolic Effects ◽  
Fibroblast Growth Factor 21 ◽  
Protein Kinase Activity ◽  
Fibroblast Growth ◽  
High Fat ◽  
Glucagon Receptor ◽  
The Metabolic Syndrome ◽  
Physiological Tests

Exercise is an effective therapy against the metabolic syndrome. However, the molecular pathways underlying the advantageous effects of exercise are elusive. Glucagon receptor signaling is essential for exercise benefits, and recent evidence indicates that a downstream effector of glucagon, fibroblast growth factor 21 (FGF21), is implicated in this response. Therefore, we tested the hypothesis that FGF21 action is necessary in mediating metabolic effects of exercise. We utilized acute exhaustive treadmill exercise in Wistar rats to identify a putative, concomitant increase in plasma glucagon and FGF21 with the increase in glucose and lactate following exercise. To test the necessity of FGF21 action in the exercise response, we exposed FGF21 congenitally deficient mice ( Fgf21 −/−) and their wild-type (Wt) littermates to chronic high-fat (HF) feeding and inoperable (sedentary) or operable (exercise) voluntary running wheels. Physiological tests were performed to assess the role of FGF21 in the beneficial effect of exercise on glucose metabolism. Wt and Fgf21 −/− littermates exhibited similar running behavior, and exercise was effective in suppressing weight and fat mass gain and dyslipidemia independently of genotype. However, exercise failed to positively affect hepatic triglyceride content and glucose tolerance in HF diet-fed Fgf21 −/− mice. Furthermore, Fgf21 −/− mice exhibited an impaired adaptation to exercise training, including reduced AMP-activated protein kinase activity in skeletal muscle. This study demonstrates that FGF21 action is necessary to achieve the full metabolic benefits of exercise during chronic HF feeding.

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