scholarly journals Abnormalities in substance P neurokinin-1 receptor binding in key brainstem nuclei in sudden infant death syndrome related to prematurity and sex

PLoS ONE ◽  
2017 ◽  
Vol 12 (9) ◽  
pp. e0184958 ◽  
Author(s):  
Fiona M. Bright ◽  
Robert Vink ◽  
Roger W. Byard ◽  
Jhodie R. Duncan ◽  
Henry F. Krous ◽  
...  
Keyword(s):  
Substance P ◽  
Sudden Infant Death Syndrome ◽  
Receptor Binding ◽  
Infant Death ◽  
Sudden Infant Death ◽  
Sudden Infant ◽  
Neurokinin 1 Receptor ◽  
Brainstem Nuclei ◽  
Neurokinin 1

Relationship of substance P and gliosis in medulla oblongata in neonatal sudden infant death syndrome

1996 ◽  
Vol 15 (3) ◽  
pp. 189-192 ◽  
Author(s):  
Toshimasa Obonai ◽  
Sachio Takashima ◽  
Laurence E. Becker ◽  
Masami Asanuma ◽  
Ryuzo Mizuta ◽  
...  
Keyword(s):  
Substance P ◽  
Sudden Infant Death Syndrome ◽  
Medulla Oblongata ◽  
Infant Death ◽  
Sudden Infant Death ◽  
Sudden Infant ◽  
Relationship Of

scholarly journals Brainstem 3H-Nicotine Receptor Binding in the Sudden Infant Death Syndrome

1998 ◽  
Vol 57 (11) ◽  
pp. 1018-1025 ◽  
Author(s):  
Dara B. Nachmanoff ◽  
Ashok Panigrahy ◽  
James J. Filiano ◽  
Frederick Mandell ◽  
Lynn A. Sleeper ◽  
...  
Keyword(s):  
Sudden Infant Death Syndrome ◽  
Receptor Binding ◽  
Infant Death ◽  
Sudden Infant Death ◽  
Sudden Infant ◽  
Nicotine Receptor

scholarly journals Decreased Kainate Receptor Binding in the Arcuate Nucleus of the Sudden Infant Death Syndrome

1997 ◽  
Vol 56 (11) ◽  
pp. 1253-1261 ◽  
Author(s):  
ASHOK PANIGRAHY ◽  
JAMES J. FILIANO ◽  
LYNN A. SLEEPER ◽  
FREDERICK MANDELL ◽  
MARIE VALDES-DAPENA ◽  
...  
Keyword(s):  
Sudden Infant Death Syndrome ◽  
Receptor Binding ◽  
Infant Death ◽  
Arcuate Nucleus ◽  
Sudden Infant Death ◽  
Kainate Receptor ◽  
Sudden Infant

Decreased muscarinic receptor binding in the arcuate nucleus in sudden infant death syndrome

Science ◽  
1995 ◽  
Vol 269 (5229) ◽  
pp. 1446-1450 ◽  
Author(s):  
H. Kinney ◽  
J. Filiano ◽  
L. Sleeper ◽  
F. Mandell ◽  
M. Valdes-Dapena ◽  
...  
Keyword(s):  
Muscarinic Receptor ◽  
Sudden Infant Death Syndrome ◽  
Receptor Binding ◽  
Infant Death ◽  
Arcuate Nucleus ◽  
Sudden Infant Death ◽  
Sudden Infant

Neuropathological Developments in Sudden Infant Death Syndrome

2018 ◽  
Vol 21 (6) ◽  
pp. 515-521 ◽  
Author(s):  
Fiona M Bright ◽  
Robert Vink ◽  
Roger W Byard
Keyword(s):  
Sudden Infant Death Syndrome ◽  
Infant Death ◽  
Risk Model ◽  
Sudden Infant Death ◽  
Reproducible Research ◽  
Sudden Infant ◽  
Unexpected Death ◽  
Integrated Network ◽  
Neurokinin 1 ◽  
Medullary Nuclei

A wide variety of neuropathological abnormalities have been investigated in infants who have died of sudden infant death syndrome (SIDS). Issues which detracted from early studies included failure to use uniform definitions of SIDS and lack of appropriately matched control populations. Development of the triple risk model focused attention on the concept of an inherent susceptibility to unexpected death in certain infants, with research demonstrating a role for the neurotransmitter serotonin within the brainstem. However, it now appears that neuropathological abnormalities in SIDS infants are more complex than a simple serotonergic deficiency in certain medullary nuclei but instead could involve failure of an integrated network of neurochemical transmitters in a variety of subcortical locations. The following overview examines recent research developments looking particularly at the potential role of the peptide neurotransmitter substance P and its neurokinin-1 receptor in multiple nuclei within the brainstem, asymmetry and microdysgenesis of the hippocampus, and decreased orexin levels within dorsomedial, perifornical, and lateral levels in the hypothalamus. Whether such research will lead to identifiable biomarker for infants at risk of SIDS is yet to be established. Use of standardized and consistent methods of classifying and categorizing infant deaths will be pivotal in generating reproducible research results.

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