Projection resolved optical coherence tomography angiography to distinguish flow signal in retinal angiomatous proliferation from flow artifact

A case of retinal arterial macroaneurysm (RAM) is presented with multimodal imaging, including commercially available optical coherence tomography angiography (OCT-A). Following treatment with intravitreal bevacizumab, reduction of flow signal through the RAM is documented. OCT-A provides useful information for the diagnosis and management of at least some patients with RAM, without the need for traditional fluorescein angiography.

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Differential flow signal strength of choroidal neovascular membrane on optical coherence tomography angiography in central serous chorioretinopathy

BMJ Case Reports ◽

10.1136/bcr-2019-232295 ◽

2019 ◽

Vol 12 (12) ◽

pp. e232295

Author(s):

Rajan Gupta ◽

Jay Chhablani

Keyword(s):

Optical Coherence Tomography ◽

Central Serous Chorioretinopathy ◽

Optical Coherence Tomography Angiography ◽

Signal Strength ◽

Optical Coherence ◽

Flow Signal ◽

New Type ◽

Associated Risk Factors

A 62-year-old woman with no associated risk factors was diagnosed as a case of type 1 choroidal neovascularisation (CNV) associated with central serous chorioretinopathy in both the eyes based on clinical features and multimodal imaging. She was primarily treated with low fluence photodynamic therapy and responded well to the treatment. There was persistence of neovascular network seen on optical coherence tomography angiography (OCTA) without any signs of activity on optical coherence tomography. However, after 5 years she developed recurrent CNV in the left eye with a new type 2 CNV as seen on OCTA which had a higher flow signal strength as compared with the previous type 1 CNV. Following two doses of intravitreal ziv-aflibercept, the new type 2 CNV network regressed as evident on OCTA along with improvement in best corrected visual acuity.

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Characterisation of vascular changes in different stages of Stargardt disease using double swept-source optical coherence tomography angiography

BMJ Open Ophthalmology ◽

10.1136/bmjophth-2019-000318 ◽

2019 ◽

Vol 4 (1) ◽

pp. e000318 ◽

Cited By ~ 1

Author(s):

Michael Reich ◽

Andreas Glatz ◽

Bertan Cakir ◽

Daniel Böhringer ◽

Stefan Lang ◽

...

Keyword(s):

Optical Coherence Tomography ◽

Optical Coherence Tomography Angiography ◽

Optical Coherence ◽

Vascular Changes ◽

Stargardt Disease ◽

Swept Source ◽

Rarefied Flow ◽

Stage Of Disease ◽

Flow Signal ◽

Avascular Zone

ObjectiveTo describe vascular changes in different stages of Stargardt disease (STGD) via double swept-source optical coherence tomography angiography.Methods and analysisProspective, cross-sectional case–control study. Twenty-three patients (45 eyes) with ABCA4 mutations graded according to the Fishman STGD classification and 23 controls (23 eyes) were included. Two independent investigators quantified the foveal avascular zone (FAZ) in the superficial and deep capillary plexus (SCP/DCP) and the areas presenting rarefied flow and complete vascular atrophy in the outer retina to choriocapillaris (ORCC) and choriocapillaris (CC) slab.ResultsThe mean age at first diagnosis of STGD was 24.0 years (range 9–50) and 37.9 years (range 18–74) at the time of examination. Eleven patients were assigned to the Fishman STGD classification stage (S) 1, three to S2, eight to S3 and one to S4. The FAZ in SCP and DCP was increased in all stages compared with controls (p<0.01). Areas with rarefied flow signal and vascular atrophy were detected in the ORCC and the CC layer and grew with increasing stage of disease (p<0.01). The duration of disease correlated with the extent of the enlarged FAZ in the SCP/DCP and with the area of reduced flow in the ORCC and CC layer (p<0.01). Best corrected visual acuity correlated negatively with the extent of the enlarged FAZ in the SCP/DCP (p<0.0001), as well as with enlarged atrophic area in the ORCC and CC layer (p=0.026 and p=0.074).ConclusionsPatients with STGD reveal vascular changes in the retina and CC in all disease stages. The avascular zone in the SCP/DCP and areas with rarefied flow signal in the ORCC/CC increase with the duration and stage of disease, indicating progressive vascular decay most likely secondary to retinal pigment epithelium and neuronal loss. Furthermore, increased vascular damage is associated with decreased vision.

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Optical Coherence Tomography Angiography of Two Choroidal Nevi Variants

Case Reports in Ophthalmological Medicine ◽

10.1155/2017/1368581 ◽

2017 ◽

Vol 2017 ◽

pp. 1-4

Author(s):

Victor M. Villegas ◽

Armando L. Monroig ◽

Lazaro H. Aguero ◽

Stephen G. Schwartz

Keyword(s):

Optical Coherence Tomography ◽

Optical Coherence Tomography Angiography ◽

Retinal Layer ◽

Optical Coherence ◽

Flow Signal ◽

Retinal Layers ◽

Vascular Flow ◽

Choroidal Nevus ◽

Choroidal Vasculature ◽

Choroidal Nevi

Optical coherence tomography angiography (OCT-A) is a recently established noninvasive technology for evaluation of the retinal and choroidal vasculature. The literature regarding the findings in choroidal nevi is scarce. We report the OCT-A findings associated with two different variants. Subject one had decreased vascular flow signal in the choroidal, choriocapillaris, deep retinal, and superficial retinal layers. Subject two had decreased vascular flow signal in the choroidal, choriocapillaris, and deep retinal layers with a normal vascular flow signal in the superficial retinal layer. To our knowledge, these patterns of decreased vascular flow signals have not been previously reported using OCT-A. This may be due to blockage from the choroidal nevus, true diminished blood flow (ischemia), or other factors.

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