scholarly journals Differential flow signal strength of choroidal neovascular membrane on optical coherence tomography angiography in central serous chorioretinopathy

2019 ◽  
Vol 12 (12) ◽  
pp. e232295
Author(s):  
Rajan Gupta ◽  
Jay Chhablani
Keyword(s):  
Optical Coherence Tomography ◽  
Central Serous Chorioretinopathy ◽  
Optical Coherence Tomography Angiography ◽  
Signal Strength ◽  
Optical Coherence ◽  
Flow Signal ◽  
New Type ◽  
Associated Risk Factors

A 62-year-old woman with no associated risk factors was diagnosed as a case of type 1 choroidal neovascularisation (CNV) associated with central serous chorioretinopathy in both the eyes based on clinical features and multimodal imaging. She was primarily treated with low fluence photodynamic therapy and responded well to the treatment. There was persistence of neovascular network seen on optical coherence tomography angiography (OCTA) without any signs of activity on optical coherence tomography. However, after 5 years she developed recurrent CNV in the left eye with a new type 2 CNV as seen on OCTA which had a higher flow signal strength as compared with the previous type 1 CNV. Following two doses of intravitreal ziv-aflibercept, the new type 2 CNV network regressed as evident on OCTA along with improvement in best corrected visual acuity.

scholarly journals Comparison of optical coherence tomography angiography features in type 1 versus type 2 choroidal neovascular membranes secondary to age-related macular degeneration

2021 ◽  
Vol 10 (2) ◽  
pp. 25-31
Author(s):  
Yasin Sakir Goker ◽  
Gokhan Demir
Keyword(s):  
Optical Coherence Tomography ◽  
Macular Degeneration ◽  
Optical Coherence Tomography Angiography ◽  
Age Related Macular Degeneration ◽  
Optical Coherence ◽  
Dead Tree ◽  
Flow Area ◽  
Age Related

Background: Optical coherence tomography angiography (OCTA) is an advanced imaging modality that provides high resolution images at the level of different retinal layers. This study aime to evaluate choroidal neovascular membranes (CNVMs) secondary to age-related macular degeneration (AMD) quantitatively and qualitatively, according to their classification, morphological features, and flow areas, using OCTA. Methods: In this descriptive, comparative, cross-sectional study, CNVMs were divided into 2 groups according to their classification as type 1 or type 2 neovascularization. Mixed CNVMs were excluded from the study. The size (mm2) and the flow area (mm2) of the CNVMs were calculated via OCTA and the presence of the perivascular halo and loop anastomoses were analyzed. The morphological appearance of the CNVMs were classified as: medusa, sea-fan, lacy-wheel, glomerular, dead tree, and mature vascular networks. Results: Of the 85 eyes assessed for eligibility, 45 eyes of 34 individuals with CNVM were enrolled in this retrospective study. Twenty-eight eyes had type 1 and 17 eyes had type 2 CNVMs. The mean size and flow area were greater in type 1 than in type 2 CNVMs (mean ± standard deviation [SD], 6.69 ± 4.54 and 3.61 ± 3.56 mm2 versus 3.04 ± 1.98 and 1.77 ± 1.62 mm2; P = 0.044 and 0.046, respectively). Among the 22 eyes with type 1 CNVMs and the 9 eyes with type 2 CNVMs, 31 eyes had exudative membranes. Among the eyes with exudative CNVMs, 22 eyes had a perivascular halo and 22 eyes had loop anastomoses; this was significantly more than in the non-exudative eyes (P = 0.042 and 0.041, respectively). The lacy-wheel (38.7%) and dead tree (71.4%) patterns were the most frequent morphological appearance of the CNVMs in the exudative and non-exudative membranes, respectively. Conclusions: OCTA provides objective documantation about CNVMs. A perivascular dark halo around CNVMs could be a criterion to define exudative membranes activity. How to cite this article: Goker YS, Demir G. Comparison of optical coherence tomography angiography features in type 1 versus type 2 choroidal neovascular membranes secondary to age-related macular degeneration. Med Hypothesis Discov Innov Ophthalmol. 2021 Summer; 10(2): 25-31. https://doi.org/10.51329/mehdiophthal1423

scholarly journals Vascular maturity of type 1 and type 2 choroidal neovascularization evaluated by optical coherence tomography angiography

PLoS ONE ◽  
2019 ◽  
Vol 14 (4) ◽  
pp. e0216304 ◽  
Author(s):  
Yuyako Nakano ◽  
Keiko Kataoka ◽  
Jun Takeuchi ◽  
Ai Fujita ◽  
Hiroki Kaneko ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Choroidal Neovascularization ◽  
Optical Coherence Tomography Angiography ◽  
Optical Coherence

scholarly journals Assessment of choriocapillary blood flow changes in response to half-dose photodynamic therapy in chronic central serous chorioretinopathy using optical coherence tomography angiography

2020 ◽  
Author(s):  
Juejun Liu ◽  
Changzheng Chen ◽  
Lu Li ◽  
Yishuang Xu ◽  
Zuohuizi Yi ◽  
...  
Keyword(s):  
Blood Flow ◽  
Optical Coherence Tomography ◽  
Photodynamic Therapy ◽  
Central Serous Chorioretinopathy ◽  
Optical Coherence Tomography Angiography ◽  
Optical Coherence ◽  
Chronic Central Serous Chorioretinopathy ◽  
Half Dose ◽  
Flow Changes

Abstract Background: Optical coherence tomography angiography (OCTA) is a newly developed imaging quantitative technique for analysis of choriocapillaris (CC) flow changes, thereby exploring the pathological mechanism of chronic central serous chorioretinopathy (CCSC) and the therapeutic effects of photodynamic therapy (PDT). In this study, we sought to quantify the blood flow changes in CC of CCSC patients receiving half-dose PDT using OCTA.Methods: A total of 28 affected eyes and 24 unaffected eyes of 26 CCSC patients receiving half-dose PDT, and 40 eyes of 20 healthy gender- and age-matched subjects were retrospectively enrolled in this study. The proportion of total areas of flow signal voids (FSV, %) in CC level of OCTA was assessed in both eyes of the CCSC patients at baseline and repeated in multiple sections at 1-week, 1-month, 3-month and 6-month intervals after PDT. In addition, the CC patterns in response to PDT at early stage and the subsequent morphologic changes were qualitatively documented using OCTA.Results: For affected eyes, FSV at 6-m follow-up was significantly lower than that at 1-m follow-up (p=0.036). When compared to normal control eyes, FSV in affected eyes was significantly higher at 1-m, 3-m and 6-m follow-up (p<0.05 for all), and FSV in unaffected eyes was significantly higher at baseline, 1-w, 1-m and 3-m follow-up (p<0.05 for all). Three CC patterns of early response to PDT were identified, including signs of recovery with more even flow signals, transient appearance of worse ischemia and secondary neovascularization within CC level.Conclusion: Abnormal CC flow attenuation remains in completely resolved eyes of CCSC patients treated with half-dose PDT.

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