scholarly journals Astrocyte responses to experimental glaucoma in mouse optic nerve head

PLoS ONE ◽  
2020 ◽  
Vol 15 (8) ◽  
pp. e0238104 ◽  
Author(s):  
Sarah Quillen ◽  
Julie Schaub ◽  
Harry Quigley ◽  
Mary Pease ◽  
Arina Korneva ◽  
...  
Keyword(s):  
Optic Nerve ◽  
Optic Nerve Head ◽  
Experimental Glaucoma

scholarly journals Static Blood Flow Autoregulation in the Optic Nerve Head in Normal and Experimental Glaucoma

2014 ◽  
Vol 55 (2) ◽  
pp. 873 ◽  
Author(s):  
Lin Wang ◽  
Claude F. Burgoyne ◽  
Grant Cull ◽  
Simon Thompson ◽  
Brad Fortune
Keyword(s):  
Blood Flow ◽  
Optic Nerve ◽  
Optic Nerve Head ◽  
Experimental Glaucoma

scholarly journals Experimental Glaucoma Causes Optic Nerve Head Neural Rim Tissue Compression: A Potentially Important Mechanism of Axon Injury

2016 ◽  
Vol 57 (10) ◽  
pp. 4403 ◽  
Author(s):  
Brad Fortune ◽  
Juan Reynaud ◽  
Christy Hardin ◽  
Lin Wang ◽  
Ian A. Sigal ◽  
...  
Keyword(s):  
Optic Nerve ◽  
Optic Nerve Head ◽  
Axon Injury ◽  
Experimental Glaucoma ◽  
Tissue Compression

Movement of retinal vessels toward the optic nerve head after increasing intraocular pressure in monkey eyes with experimental glaucoma

2017 ◽  
Vol 162 ◽  
pp. 110-115 ◽  
Author(s):  
Atsumi Kuroda ◽  
Nobuko Enomoto ◽  
Kyoko Ishida ◽  
Masamitsu Shimazawa ◽  
Tetsuro Noguchi ◽  
...  
Keyword(s):  
Intraocular Pressure ◽  
Optic Nerve ◽  
Optic Nerve Head ◽  
Retinal Vessels ◽  
Experimental Glaucoma

scholarly journals In Vivo Changes in Lamina Cribrosa Microarchitecture and Optic Nerve Head Structure in Early Experimental Glaucoma

PLoS ONE ◽  
2015 ◽  
Vol 10 (7) ◽  
pp. e0134223 ◽  
Author(s):  
Kevin M. Ivers ◽  
Nripun Sredar ◽  
Nimesh B. Patel ◽  
Lakshmi Rajagopalan ◽  
Hope M. Queener ◽  
...  
Keyword(s):  
Optic Nerve ◽  
Optic Nerve Head ◽  
Lamina Cribrosa ◽  
Experimental Glaucoma

scholarly journals The role of aquaporin-4 in optic nerve head astrocytes in experimental glaucoma

PLoS ONE ◽  
2021 ◽  
Vol 16 (2) ◽  
pp. e0244123
Author(s):  
Elizabeth Kimball ◽  
Julie Schaub ◽  
Sarah Quillen ◽  
Casey Keuthan ◽  
Mary Ellen Pease ◽  
...  
Keyword(s):  
Optic Nerve ◽  
Optic Nerve Head ◽  
Aquaporin 4 ◽  
Ocular Tissue ◽  
Aqp4 Expression ◽  
Experimental Glaucoma ◽  
Axon Loss ◽  
Channel Expression ◽  
Iop Elevation ◽  
Bead Injection

Purpose To study aquaporin channel expression in astrocytes of the mouse optic nerve (ON) and the response to IOP elevation in mice lacking aquaporin 4 (AQP4 null). Methods C57BL/6 (B6) and AQP4 null mice were exposed to bead-induced IOP elevation for 3 days (3D-IOP), 1 and 6 weeks. Mouse ocular tissue sections were immunolabeled against aquaporins 1(AQP1), 4(AQP4), and 9(AQP9). Ocular tissue was imaged to identify normal AQP distribution, ON changes, and axon loss after IOP elevation. Ultrastructure examination, cell proliferation, gene expression, and transport block were also analyzed. Results B6 mice had abundant AQP4 expression in Müller cells, astrocytes of retina and myelinated ON (MON), but minimal AQP4in prelaminar and unmyelinated ON (UON). MON of AQP4 nulls had smaller ON area, smaller axon diameter, higher axon density, and larger proportionate axon area than B6 (all p≤0.05). Bead-injection led to comparable 3D-IOP elevation (p = 0.42) and axonal transport blockade in both strains. In B6, AQP4 distribution was unchanged after 3D-IOP. At baseline, AQP1 and AQP9 were present in retina, but not in UON and this was unaffected after IOP elevation in both strains. In 3D-IOP mice, ON astrocytes and microglia proliferated, more in B6 than AQP4 null. After 6 week IOP elevation, axon loss occurred equally in the two mouse types (24.6%, AQP4 null vs. 23.3%, B6). Conclusion Lack of AQP4 was neither protective nor detrimental to the effects of IOP elevation. The minimal presence of AQP4 in UON may be a vital aspect of the regionally specific phenotype of astrocytes in the mouse optic nerve head.

scholarly journals Changes in the Biomechanical Response of the Optic Nerve Head in Early Experimental Glaucoma

2010 ◽  
Vol 51 (11) ◽  
pp. 5675 ◽  
Author(s):  
Michael D. Roberts ◽  
Ian A. Sigal ◽  
Yi Liang ◽  
Claude F. Burgoyne ◽  
J. Crawford Downs
Keyword(s):  
Optic Nerve ◽  
Optic Nerve Head ◽  
Experimental Glaucoma ◽  
Biomechanical Response

scholarly journals The Connective Tissue Components of Optic Nerve Head Cupping in Monkey Experimental Glaucoma Part 1: Global Change

2015 ◽  
Vol 56 (13) ◽  
pp. 7661 ◽  
Author(s):  
Hongli Yang ◽  
Ruojin Ren ◽  
Howard Lockwood ◽  
Galen Williams ◽  
Vincent Libertiaux ◽  
...  
Keyword(s):  
Optic Nerve ◽  
Global Change ◽  
Connective Tissue ◽  
Optic Nerve Head ◽  
Experimental Glaucoma

Optic Nerve Head Blood Flow in Chronic Experimental Glaucoma

1985 ◽  
Vol 103 (7) ◽  
pp. 956-962 ◽  
Author(s):  
H. A. Quigley ◽  
R. M. Hohman ◽  
R. Sanchez ◽  
E. M. Addicks
Keyword(s):  
Blood Flow ◽  
Optic Nerve ◽  
Optic Nerve Head ◽  
Experimental Glaucoma
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