Nuclear PYHIN proteins target the host transcription factor Sp1 thereby restricting HIV-1 in human macrophages and CD4+ T cells

Matteo Bosso; Caterina Prelli Bozzo; Dominik Hotter; Meta Volcic; Christina M. Stürzel; Annika Rammelt; Yi Ni; Stephan Urban; Miriam Becker; Mario Schelhaas; Sabine Wittmann; Maria H. Christensen; Florian I. Schmidt; Thomas Gramberg; Konstantin M. J. Sparrer; Daniel Sauter; Frank Kirchhoff

doi:10.1371/journal.ppat.1008752

Nuclear PYHIN proteins target the host transcription factor Sp1 thereby restricting HIV-1 in human macrophages and CD4+ T cells

PLoS Pathogens ◽

10.1371/journal.ppat.1008752 ◽

2020 ◽

Vol 16 (8) ◽

pp. e1008752 ◽

Cited By ~ 3

Author(s):

Matteo Bosso ◽

Caterina Prelli Bozzo ◽

Dominik Hotter ◽

Meta Volcic ◽

Christina M. Stürzel ◽

...

Keyword(s):

T Cells ◽

Transcription Factor ◽

Cd4 T Cells ◽

Human Macrophages ◽

Transcription Factor Sp1 ◽

Hiv 1

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The γc-cytokine regulated transcription factor, STAT5, increases HIV-1 production in primary CD4 T cells

Virology ◽

10.1016/j.virol.2005.09.063 ◽

2006 ◽

Vol 344 (2) ◽

pp. 283-291 ◽

Cited By ~ 28

Author(s):

Nithianandan Selliah ◽

Mingce Zhang ◽

Dennis DeSimone ◽

Hellen Kim ◽

Michael Brunner ◽

...

Keyword(s):

T Cells ◽

Transcription Factor ◽

Cd4 T Cells ◽

Hiv 1

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Bioclinical Evaluation of 2 Biomarkers of Aviremic HIV-1 in CD4+ T Cells of Adults Undergoing Treatment

Case Medical Research ◽

10.31525/ct1-nct03940521 ◽

2019 ◽

Author(s):

Keyword(s):

T Cells ◽

Cd4 T Cells ◽

Hiv 1

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Faculty Opinions recommendation of HIV-1 viremia prevents the establishment of interleukin 2-producing HIV-specific memory CD4+ T cells endowed with proliferative capacity.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1016864.201588 ◽

2004 ◽

Author(s):

Luis J Montaner

Keyword(s):

T Cells ◽

Cd4 T Cells ◽

Interleukin 2 ◽

Proliferative Capacity ◽

Specific Memory ◽

Memory Cd4 T Cells ◽

Hiv 1

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Faculty Opinions recommendation of The contribution of transcription factor IRF1 to the interferon-gamma-interleukin 12 signaling axis and TH1 versus TH-17 differentiation of CD4+ T cells.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1099170.555385 ◽

2008 ◽

Author(s):

Rachel R Caspi

Keyword(s):

T Cells ◽

Transcription Factor ◽

Interferon Gamma ◽

Cd4 T Cells ◽

Interleukin 12 ◽

Th 17 ◽

Signaling Axis

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Faculty Opinions recommendation of Transcription factor FOXO3a controls the persistence of memory CD4(+) T cells during HIV infection.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1104534.569097 ◽

2008 ◽

Author(s):

Vicente Planelles

Keyword(s):

T Cells ◽

Transcription Factor ◽

Hiv Infection ◽

Cd4 T Cells ◽

Memory Cd4 T Cells

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Faculty Opinions recommendation of Induction of HIV-1 latency and reactivation in primary memory CD4+ T cells.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1135842.592930 ◽

2008 ◽

Author(s):

David Camerini ◽

Alvaro Galvis

Keyword(s):

T Cells ◽

Cd4 T Cells ◽

Primary Memory ◽

Memory Cd4 T Cells ◽

Hiv 1

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Faculty Opinions recommendation of [CONFERENCE POSTER]: Intrinsic resistance to HIV-1 of macrophages and CD4+ T cells from HIV controllers.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.12527956.13754054 ◽

2011 ◽

Author(s):

Gabriella Scarlatti ◽

Simone Pensieroso

Keyword(s):

T Cells ◽

Cd4 T Cells ◽

Intrinsic Resistance ◽

Hiv Controllers ◽

Hiv 1

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Faculty Opinions recommendation of HIV-1 DNA is detected in bone marrow populations containing CD4+ T cells but is not found in purified CD34+ hematopoietic progenitor cells in most patients on antiretroviral therapy.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.13829974.15269081 ◽

2012 ◽

Author(s):

Mark Wainberg ◽

Richard Sloan

Keyword(s):

Bone Marrow ◽

T Cells ◽

Antiretroviral Therapy ◽

Progenitor Cells ◽

Cd4 T Cells ◽

Hematopoietic Progenitor Cells ◽

Hematopoietic Progenitor ◽

Hiv 1

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Faculty Opinions recommendation of Distinct gene-expression profiles associated with the susceptibility of pathogen-specific CD4 T cells to HIV-1 infection.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.717980795.793471790 ◽

2013 ◽

Author(s):

Paul Goepfert ◽

Anju Bansal

Keyword(s):

Gene Expression ◽

T Cells ◽

Cd4 T Cells ◽

Expression Profiles ◽

Gene Expression Profiles ◽

Distinct Gene ◽

Hiv 1

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Faculty Opinions recommendation of Lifespan of effector memory CD4+ T cells determined by replication-incompetent integrated HIV-1 provirus.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.718264442.793491515 ◽

2014 ◽

Author(s):

Andrew Badley ◽

Nathan Cummins

Keyword(s):

T Cells ◽

Cd4 T Cells ◽

Effector Memory ◽

Memory Cd4 T Cells ◽

Hiv 1

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