THE INHALED MUSCARINIC RECEPTOR ANTAGONIST, GLYCOPYRROLATE, HAS A FAVORABLE SIDE EFFECT PROFILE IN A BROWN NORWAY RAT LUNG FUNCTION MODEL WHEN COMPARED WITH TIOTROPIUM

CHEST Journal ◽  
2007 ◽  
Vol 132 (4) ◽  
pp. 530A ◽  
Author(s):  
Alexandre Trifilieff ◽  
Nathan Cope ◽  
Barbara Bohacek ◽  
Lazzaro Mazzoni ◽  
Collingwood Steve
Keyword(s):  
Lung Function ◽  
Receptor Antagonist ◽  
Side Effect ◽  
Brown Norway ◽  
Side Effect Profile ◽  
Rat Lung ◽  
Function Model ◽  
Norway Rat ◽  
Brown Norway Rat ◽  
Favorable Side Effect Profile

scholarly journals Inducible nitric oxide synthase after sensitization and allergen challenge of Brown Norway rat lung

1997 ◽  
Vol 121 (7) ◽  
pp. 1241-1246 ◽  
Author(s):  
Shu Fang Liu ◽  
El-Bdaoui Haddad ◽  
Ian Adcock ◽  
Michael Salmon ◽  
Hiro Koto ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Inducible Nitric Oxide Synthase ◽  
Allergen Challenge ◽  
Brown Norway ◽  
Rat Lung ◽  
Norway Rat ◽  
Brown Norway Rat ◽  
Oxide Synthase ◽  
Inducible Nitric Oxide

scholarly journals Effet of Combined Nitrogen Dioxide and Carbon Nanoparticle Exposure on Lung Function During Ovalbumin Sensitization in Brown Norway Rat

PLoS ONE ◽  
2012 ◽  
Vol 7 (9) ◽  
pp. e45687 ◽  
Author(s):  
Skander Layachi ◽  
Françoise Rogerieux ◽  
Franck Robidel ◽  
Ghislaine Lacroix ◽  
Sam Bayat
Keyword(s):  
Lung Function ◽  
Nitrogen Dioxide ◽  
Brown Norway ◽  
Carbon Nanoparticle ◽  
Norway Rat ◽  
Nanoparticle Exposure ◽  
Combined Nitrogen ◽  
Brown Norway Rat

MEL-N16: A Series of Novel Endomorphin Analogs with Good Analgesic Activity and a Favorable Side Effect Profile

2017 ◽  
Vol 8 (10) ◽  
pp. 2180-2193 ◽  
Author(s):  
Xin Liu ◽  
Long Zhao ◽  
Yuan Wang ◽  
Jingjing Zhou ◽  
Dan Wang ◽  
...  
Keyword(s):  
Analgesic Activity ◽  
Side Effect ◽  
Side Effect Profile ◽  
Favorable Side Effect Profile

scholarly journals Knockdown of Add3 impairs the myogenic response of renal afferent arterioles and middle cerebral arteries

2017 ◽  
Vol 312 (6) ◽  
pp. F971-F981 ◽  
Author(s):  
Fan Fan ◽  
Mallikarjuna R. Pabbidi ◽  
Ying Ge ◽  
Longyang Li ◽  
Shaoxun Wang ◽  
...  
Keyword(s):  
Vascular Reactivity ◽  
Vascular Dysfunction ◽  
Cerebral Arteries ◽  
Chromosome 1 ◽  
Brown Norway ◽  
Myogenic Response ◽  
Norway Rat ◽  
Vasoconstrictor Response ◽  
Brown Norway Rat ◽  
Interfering Rna

We have reported that the myogenic response of the renal afferent arteriole (Af-art) and middle cerebral artery (MCA) and autoregulation of renal and cerebral blood flow are impaired in Fawn-Hooded Hypertensive (FHH) rats. Transfer of a region of chromosome 1 containing γ-adducin (Add3) from the Brown Norway rat rescued the vascular dysfunction and the development of renal disease. To examine whether Add3 is a viable candidate gene altering renal and cerebral hemodynamics in FHH rats, we knocked down the expression of Add3 in rat Af-arts and MCAs cultured for 36-h using a 27-mer Dicer-substrate short interfering RNA (DsiRNA). Control Af-arts constricted by 10 ± 1% in response to an elevation in pressure from 60 to 120 mmHg but dilated by 4 ± 3% when treated with Add3 DsiRNA. Add3 DsiRNA had no effect on the vasoconstrictor response of the Af-art to norepinephrine (10−7 M). Add3 DsiRNA had a similar effect on the attenuation of the myogenic response in the MCA. Peak potassium currents were threefold higher in smooth muscle cells isolated from Af-arts or MCAs transfected with Add3 DsiRNA than in nontransfected cells isolated from the same vessels. This is the first study demonstrating that Add3 plays a role in the regulation of potassium channel function and vascular reactivity. It supports the hypothesis that sequence variants in Add3, which we previously identified in FHH rats, may play a causal role in the impaired myogenic response and autoregulation in the renal and cerebral circulation.

Sign in / Sign up

Export Citation Format

Share Document