Gene Silencing Using Small Interference RNA in Mast Cells

Mast Cells ◽  
2005 ◽  
pp. 333-340
Author(s):  
Deling Yin ◽  
Charles A. Stuart
Keyword(s):  
Mast Cells ◽  
Gene Silencing ◽  
Small Interference Rna ◽  
Interference Rna

Gene Silencing in Rat-Liver and Limb Grafts by Rapid Injection of Small Interference RNA

2005 ◽  
Vol 79 (2) ◽  
pp. 240-243 ◽  
Author(s):  
Yuki Sato ◽  
Takashi Ajiki ◽  
Seiichiro Inoue ◽  
Jun Fujishiro ◽  
Hiroyuki Yoshino ◽  
...  
Keyword(s):  
Gene Silencing ◽  
Rat Liver ◽  
Small Interference Rna ◽  
Rapid Injection ◽  
Interference Rna

Gene Silencing using siRNA for Preventing Liver Ischaemia-Reperfusion Injury

2018 ◽  
Vol 24 (23) ◽  
pp. 2692-2700 ◽  
Author(s):  
H. Susana Marinho ◽  
Paulo Marcelino ◽  
Helena Soares ◽  
Maria Luísa Corvo
Keyword(s):  
Gene Silencing ◽  
Reperfusion Injury ◽  
Therapeutic Potential ◽  
Major Complication ◽  
Ischaemia Reperfusion Injury ◽  
Small Interference Rna ◽  
Ischaemia Reperfusion ◽  
Promising Therapeutic Approach ◽  
Sirna Therapy

Background: Ischaemia-reperfusion injury (IRI), a major complication occurring during organ transplantation, involves an initial ischemia insult, due to loss of blood supply, followed by an inflammation-mediated reperfusion injury. A variety of molecular targets and pathways involved in liver IRI have been identified. Gene silencing through RNA interference (RNAi) by means of small interference RNA (siRNA) targeting mediators of IRI is a promising therapeutic approach. Objective: This study aims at reviewing the use of siRNAs as therapeutic agents to prevent IRI during liver transplantation. Method: We review the crucial choice of siRNA targets and the advantages and problems of the use of siRNAs. Results: We propose possible targets for siRNA therapy during liver IRI. Moreover, we discuss how drug delivery systems, namely liposomes, may improve siRNA therapy by increasing siRNA stability in vivo and avoiding siRNA off-target effects. Conclusion: siRNA therapeutic potential to preclude liver IRI can be improved by a better knowledge of what molecules to target and by using more efficient delivery strategies.

scholarly journals Identification of Human Kinases Involved in Hepatitis C Virus Replication by Small Interference RNA Library Screening

2007 ◽  
Vol 283 (1) ◽  
pp. 29-36 ◽  
Author(s):  
Lubica Supekova ◽  
Frantisek Supek ◽  
Jongkook Lee ◽  
Shawn Chen ◽  
Nathanael Gray ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Virus Replication ◽  
Library Screening ◽  
Small Interference Rna ◽  
Interference Rna

scholarly journals Magnetic gold nanoparticle-mediated small interference RNA silencing Bag-1 gene for colon cancer therapy

2015 ◽  
Vol 35 (2) ◽  
pp. 978-984 ◽  
Author(s):  
WENBAI HUANG ◽  
ZHAN'AO LIU ◽  
GUANZHOU ZHOU ◽  
AILING TIAN ◽  
NIANFENG SUN
Keyword(s):  
Colon Cancer ◽  
Cancer Therapy ◽  
Gold Nanoparticle ◽  
Rna Silencing ◽  
Small Interference Rna ◽  
Interference Rna
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