scholarly journals Side effects of long-term antiepileptic drugs on renal tubules of Indonesian children

2018 ◽  
Vol 58 (2) ◽  
pp. 84-9
Author(s):  
Partini Pudjiastuti Trihono ◽  
Deasy Grafianti ◽  
Irawan Mangunatmadja ◽  
Mulya Rahma Karyanti
Keyword(s):  
Combination Therapy ◽  
Antiepileptic Drugs ◽  
Tubular Function ◽  
Control Group ◽  
Renal Tubules ◽  
Healthy Children ◽  
Renal Tubular Function ◽  
Long Term Treatment ◽  
Renal Tubular

Background Long-term treatment with antiepileptic drugs such as valproic acid (VPA) and carbamazepine (CBZ) may disrupt renal tubular function. Urinary N-acetyl-beta-D-glucosaminidase (NAG) may reflect tubular function and may be useful in detecting early-stage tubular injury. To date, no study has investigated the toxic effect of VPA and CBZ on renal tubules using urinary NAG in Indonesian children. Objectives To determine the toxicity of long-term VPA and/or CBZ treatment on renal tubules in children with epilepsy by measuring urinary NAG index (iNAG). Methods This cross-sectional study was conducted from January to March 2015 at Cipto Mangunkusumo Hospital and Anakku Clinic Pondok Pinang, Jakarta. We included children aged 3 to 16 years with epilepsy on VPA (n=36), CBZ (n=14), or VPA-CBZ combination (n=14) therapy. We measured urinary levels of creatinine and NAG. The urinary NAG reference value was obtained from age-matched healthy controls (n=30). To eliminate diurnal variations in NAG, iNAG was calculated by dividing urinary NAG by urinary creatinine. A urinary iNAG of more than two standard deviations above the mean for healthy children was considered elevated. Results Mean urinary iNAG values for the control, VPA, CBZ, and combination groups were 3.01, 5.9, 4.07, and 6.9 U/g, respectively. All treated groups had higher mean urinary iNAG values compared to the control group. Urinary iNAG was increased in 11/36 children on VPA, 2/14 children on CBZ, and 9/14 children on combination therapy. Conclusion Long-term VPA use may impair renal tubular function, as shown by the increased urinary iNAG. Combination therapy increases damage in the renal tubules.

scholarly journals Specificity of pH and osmolality of early morning urine sample in assessing distal renal tubular function in children: results in healthy children

BMJ ◽  
1996 ◽  
Vol 312 (7042) ◽  
pp. 1337-1338 ◽  
Author(s):  
R. Skinner ◽  
M. Cole ◽  
A. D J Pearson ◽  
M. G Coulthard ◽  
A. W Craft
Keyword(s):  
Urine Sample ◽  
Early Morning ◽  
Tubular Function ◽  
Healthy Children ◽  
Renal Tubular Function ◽  
Renal Tubular

scholarly journals Side Effects of Antiepileptic Drugs on Renal Tubular Function in Childhood-onset Epilepsy

2012 ◽  
Vol 71 (4) ◽  
pp. 248-251
Author(s):  
Ayumi Endo ◽  
Yukihiko Fujita ◽  
Tatsuo Fuchigami ◽  
Shori Takahashi ◽  
Hideo Mugishima
Keyword(s):  
Side Effects ◽  
Antiepileptic Drugs ◽  
Tubular Function ◽  
Childhood Onset ◽  
Renal Tubular Function ◽  
Renal Tubular

scholarly journals Momordica charantia (Bitter melon) in Combination with Metformin Potentiates Hypoglycemic and Hypolipidemic Effects in Alloxan-induced Diabetic Rats

2018 ◽  
Vol 21 (2) ◽  
pp. 109-117
Author(s):  
Monirul Islam ◽  
Md Saiful Islam ◽  
Shaheda Zannah ◽  
Golam Sadik ◽  
Mamunur Rashid
Keyword(s):  
Combination Therapy ◽  
Treatment Protocol ◽  
Liver Glycogen ◽  
Term Treatment ◽  
Fixed Dose ◽  
Control Group ◽  
Bitter Melon ◽  
Short Term ◽  
Long Term Treatment

The present study was designed to investigate the effects of bitter melon (Momordica charantia) in combination with a standard oral hypoglycemic agent metformin on alloxan induced diabetic rats (AIDRs). Both the plant extract and the drug, individually and in combination, were subjected in vivo for two weeks (short term) and four weeks (long term) treatment protocol to determine blood glucose level, lipid profile and liver glycogen level using Swiss Albino rats. In short term treatment protocol, bitter melon extract (BME) at a dose of 75, 150 and 300 mg/ kg body weight (bw) were administered in AIDRs by using oral gavages once daily and dose-dependent antihyperglycemic and antidyslipidemic effects were investigated. This short term study revealed that the most effective dose of BME was found as 300 mg/kg bw among the three doses. In long term treatment protocol, AIDRs in different groups received fixed dose monotherapy of BME (300 mg/kg bw) and metformin (15 mg/kg bw) and fixed dose BME (150 mg/kg bw) and metformin (7.5 mg/kg bw) combination therapy. The study showed that combination therapy significantly decreased the blood glucose level from 18.42 ± 0.95 to 6.80 ± 0.39 mmol/l in comparison to the control group after daily treatment for four weeks. In case of antidyslipidemic effect, combination therapy reduced total cholesterol (34.25%), triglycerides (11.92%) and LDL-cholesterol (57.73%) levels and increased HDL-cholesterol level (55.48%) in comparison with their respective control groups. Metformin, BME and their combination preserved the liver glycogen level by 35.21%, 22.54% and 49.01%, respectively in comparison to diabetic control group. These changes were significantly better than those of BME and metformin monotherapy. The results suggested that treatment with combination therapy was more effective than mono-therapy for preventing diabetes as bitter melon extract potentiates the effects of metformin on long term alloxan-induced diabetic rats.Bangladesh Pharmaceutical Journal 21(2): 109-117, 2018

scholarly journals Renal Tubular Function in Patients Receiving Anticonvulsant Therapy: A Long-Term Study

Epilepsia ◽  
2000 ◽  
Vol 41 (11) ◽  
pp. 1432-1435 ◽  
Author(s):  
A. Verrotti ◽  
R. Greco ◽  
R. Pascarella ◽  
V. Matera ◽  
G. Morgese ◽  
...  
Keyword(s):  
Anticonvulsant Therapy ◽  
Tubular Function ◽  
Term Study ◽  
Renal Tubular Function ◽  
Long Term Study ◽  
Renal Tubular

Radioiodinated peanut lectin: Clinical use as a tumour-imaging agent and potential use in assessing renal-tubular function

1986 ◽  
Vol 11 (9) ◽  
pp. 350-354 ◽  
Author(s):  
E. A. Abdi ◽  
V. J. Kamitomo ◽  
T. A. McPherson ◽  
Z. Catz ◽  
G. Boniface ◽  
...  
Keyword(s):  
Tubular Function ◽  
Imaging Agent ◽  
Clinical Use ◽  
Tumour Imaging ◽  
Peanut Lectin ◽  
Renal Tubular Function ◽  
Renal Tubular ◽  
Potential Use

Cystinosis: renal glomerular and renal tubular function in relation to compliance with cystine-depleting therapy

2014 ◽  
Vol 30 (6) ◽  
pp. 945-951 ◽  
Author(s):  
Galina Nesterova ◽  
Caitlyn Williams ◽  
Isa Bernardini ◽  
William A. Gahl
Keyword(s):  
Tubular Function ◽  
Renal Tubular Function ◽  
Renal Tubular
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