scholarly journals MANAGEMENT OF INFECTED FRACTURE NON-UNION OF LONG BONES BY MASQUELET TECHNIQUE IN PATIENTS WITH BONE LOSS LESS THAN 4 CM

2018 ◽  
Vol 7 (33) ◽  
pp. 3715-3720
Author(s):  
Bellary Mohammed Ghouse ◽  
Koti Satish ◽  
Buchireddy Jayachandra Reddy ◽  
Zeeshan Mujahid
Biomedicine ◽  
2021 ◽  
Vol 41 (4) ◽  
pp. 811-814
Author(s):  
Senthil Loganathan ◽  
Sradha Murali ◽  
U. Thiyagarajan ◽  
D. Gokulraj

Introduction and Aim: Masquelet’s technique is a 2-staged procedure, for treatment of infected segmental bone defect. 1st stage involves radical debridement with antibiotic-induced cement spacer. During second stage, the spacer is removed and the autologous bone graft is applied into the biomembrane formed. In this study, we evaluate the Masquelet’s technique for the management of infective non-union of long bones.   Materials and Methods: 15 patients with infective non-union of long bones- tibia, femur and a case of congenital pseudoarthrosis of tibia, were treated with Masquelet’s technique. They underwent 2 stages of procedures 6-8 weeks apart and was followed up for about 9 months and radiological and clinical outcomes were assessed.   Results: Out of 15 patients with infective non-union, 8 patients attained union. Out of the 7 patients with failure of the technique, higher failure rates were attributed to Pseudomonas infection.   Conclusion: Masquelet’s technique is a cost-effective method for treating infective segmental non-unions, not requiring special training or sophisticated instruments. This method shows good results with Gram positive infections. Although, the outcome with Pseudomonas aeruginosa infection, have not shown satisfactory results.


2021 ◽  
Vol 4 (1) ◽  
Author(s):  
Lei Qin ◽  
Xuekun Fu ◽  
Jing Ma ◽  
Manxia Lin ◽  
Peijun Zhang ◽  
...  

AbstractOsteocytes act as mechanosensors in bone; however, the underlying mechanism remains poorly understood. Here we report that deleting Kindlin-2 in osteocytes causes severe osteopenia and mechanical property defects in weight-bearing long bones, but not in non-weight-bearing calvariae. Kindlin-2 loss in osteocytes impairs skeletal responses to mechanical stimulation in long bones. Control and cKO mice display similar bone loss induced by unloading. However, unlike control mice, cKO mice fail to restore lost bone after reloading. Osteocyte Kindlin-2 deletion impairs focal adhesion (FA) formation, cytoskeleton organization and cell orientation in vitro and in bone. Fluid shear stress dose-dependently increases Kindlin-2 expression and decreases that of Sclerostin by downregulating Smad2/3 in osteocytes; this latter response is abolished by Kindlin-2 ablation. Kindlin-2-deficient osteocytes express abundant Sclerostin, contributing to bone loss in cKO mice. Collectively, we demonstrate an indispensable novel role of Kindlin-2 in maintaining skeletal responses to mechanical stimulation by inhibiting Sclerostin expression during osteocyte mechanotransduction.


Injury ◽  
1979 ◽  
Vol 10 (2) ◽  
pp. 92-98 ◽  
Author(s):  
V.P. Okhotsky ◽  
A.G. Souvalyan
Keyword(s):  

1967 ◽  
Vol 38 (1-4) ◽  
pp. 341-358 ◽  
Author(s):  
L. E. Laurent ◽  
A. Langenskiöld
Keyword(s):  

2018 ◽  
Vol 42 (12) ◽  
pp. 2933-2939 ◽  
Author(s):  
Gamal Ahmed Hosny ◽  
Abdel-Salam Abdel-Aleem Ahmed ◽  
Mohamed Abd-Elaal Hussein

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