scholarly journals Impact of Obesity and Alanine Aminotransferase Levels on the Diagnostic Accuracy for Advanced Liver Fibrosis of Noninvasive Tools in Patients With Nonalcoholic Fatty Liver Disease

2019 ◽  
Vol 114 (6) ◽  
pp. 916-928 ◽  
Author(s):  
Salvatore Petta ◽  
Vincent Wai-Sun Wong ◽  
Elisabetta Bugianesi ◽  
Anna Ludovica Fracanzani ◽  
Calogero Cammà ◽  
...  
Keyword(s):  
Liver Disease ◽  
Liver Fibrosis ◽  
Diagnostic Accuracy ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Alanine Aminotransferase ◽  
Fatty Liver Disease ◽  
Nonalcoholic Fatty Liver ◽  
Advanced Liver Fibrosis

scholarly journals The BARD score and the NAFLD fibrosis score in the assessment of advanced liver fibrosis in nonalcoholic fatty liver disease

2012 ◽  
Vol 18 (12) ◽  
pp. CR735-CR740 ◽  
Author(s):  
Halina Cichoż-Lach ◽  
Krzysztof Celiński ◽  
Beata Prozorow-Król ◽  
Jarosław Swatek ◽  
Maria Słomka ◽  
...  
Keyword(s):  
Liver Disease ◽  
Liver Fibrosis ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Fatty Liver Disease ◽  
Fibrosis Score ◽  
Nonalcoholic Fatty Liver ◽  
Nafld Fibrosis Score ◽  
Advanced Liver Fibrosis

scholarly journals The Appropriate Opportunity for Evaluating Liver Fibrosis by Using the FIB-4 Index in Patients with Nonalcoholic Fatty Liver Disease in Japan

Diagnostics ◽  
2020 ◽  
Vol 10 (10) ◽  
pp. 842
Author(s):  
Yuya Seko ◽  
Kota Yano ◽  
Aya Takahashi ◽  
Shinya Okishio ◽  
Seita Kataoka ◽  
...  
Keyword(s):  
Liver Disease ◽  
Liver Fibrosis ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Predictive Factor ◽  
Fatty Liver Disease ◽  
Cutoff Point ◽  
Advanced Fibrosis ◽  
Nonalcoholic Fatty Liver ◽  
Advanced Liver Fibrosis

In patients with nonalcoholic fatty liver disease (NAFLD), liver fibrosis is the predictive factor for liver-related events and prognosis. This retrospective study aimed to evaluate longitudinal changes in the FIB-4 index and to determine a strategy for diagnosing and following patients with NAFLD using this index. We analyzed the FIB-4 index at baseline and after 1 and 5 years in 272 consecutive patients with biopsy-proven NAFLD. Of these, 52 patients underwent serial biopsies. The change in the FIB-4 index was correlated with changes in the fibrosis stage among these patients (p = 0.048). The median FIB-4 index was 1.64 at baseline, 1.45 at 1 year, and 1.74 at 5 years. The negative predictive value for advanced fibrosis at a low cutoff point was 90.4/90.1 at baseline/1 year. Its specificity at a high cutoff point increased from 65.0% at baseline to 82.3% at 1 year. Multivariate analysis identified the FIB-4 index at 1 year as a predictive factor for a FIB-4 index > 2.67 at 5 years. A FIB-4 index < 1.30 was acceptable for excluding advanced fibrosis at baseline. In contrast, to evaluate and predict advanced liver fibrosis with the FIB-4 index at a high cutoff point, we should use the index at 1 year after appropriate therapy.

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