Remediation of polluted sediments in the Ashtabula River Area of Concern on Lake Erie:

There is no doubt that the immense amount of information that is being generated by the initial sequencing and secondary interrogation of various genomes will change the face of glycobiological research. However, a major area of concern is that detailed structural knowledge of the ultimate products of genes that are identified as being involved in glycoconjugate biosynthesis is still limited. This is illustrated clearly by the nematode worm Caenorhabditis elegans, which was the first multicellular organism to have its entire genome sequenced. To date, only limited structural data on the glycosylated molecules of this organism have been reported. Our laboratory is addressing this problem by performing detailed MS structural characterization of the N-linked glycans of C. elegans; high-mannose structures dominate, with only minor amounts of complex-type structures. Novel, highly fucosylated truncated structures are also present which are difucosylated on the proximal N-acetylglucosamine of the chitobiose core as well as containing unusual Fucα1–2Gal1–2Man as peripheral structures. The implications of these results in terms of the identification of ligands for genomically predicted lectins and potential glycosyltransferases are discussed in this chapter. Current knowledge on the glycomes of other model organisms such as Dictyostelium discoideum, Saccharomyces cerevisiae and Drosophila melanogaster is also discussed briefly.

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Drug-coated Balloons – History and Peripheral Vascular Opportunities

Interventional Cardiology Review ◽

10.15420/icr.2010.5.1.70 ◽

2010 ◽

Vol 5 (1) ◽

pp. 70

Author(s):

Bruno Scheller ◽

Bodo Cremers ◽

Stephanie Schmitmeier ◽

Beatrix Schnorr ◽

Yvonne Clever ◽

...

Keyword(s):

Arterial Disease ◽

Local Drug Delivery ◽

Term Outcome ◽

Long Term Outcome ◽

Late Lumen Loss ◽

Short Term Exposure ◽

History Of ◽

Area Of Concern ◽

Peripheral Arterial ◽

Drug Coated Balloon

One of the most innovative fields of modern medical research is the percutaneous transluminal treatment of vascular disease. During recent decades considerable advances have been made in intravascular interventions for the treatment of coronary and peripheral arterial disease. Despite these advances, the long-term outcome remains an area of concern in many applications. Restenosis is still a challenge in endovascular medicine and has thus been referred to as the Achilles’ heel of percutaneous intervention. Therefore, novel strategies have been developed to overcome this problem. These include drug-eluting stents and the more recently introduced non-stent-based local drug delivery systems (in particular the drug-coated balloon). Results from several pre-clinical and clinical studies indicate that short-term exposure of injured arteries to paclitaxel delivered from regular angioplasty balloons may be sufficient to reduce late lumen loss and restenosis rates during a critical period of time after the angioplasty of diseased coronary and peripheral arteries. Although the number of published trials and patients treated is still limited, data available seem to prove that restenosis inhibition by immediate drug release is feasible. This article reviews the history of the drug-coated balloon and then focuses on peripheral artery trials.

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Life History and Production of Walleyes of the 1959 Year-Class in Western Lake Erie, 1959–62

Transactions of the American Fisheries Society ◽

10.1577/1548-8659(1972)101<655:lhapow>2.0.co;2 ◽

1972 ◽

Vol 101 (4) ◽

pp. 655-661 ◽

Cited By ~ 2

Author(s):

John W. Parsons

Keyword(s):

Life History ◽

Lake Erie ◽

Western Lake ◽

Western Lake Erie

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Quota Management and “People Problems”: A Case History of Canadian Lake Erie Fisheries

Transactions of the American Fisheries Society ◽

10.1577/1548-8659(1987)116<494:qmapp>2.0.co;2 ◽

1987 ◽

Vol 116 (3) ◽

pp. 494-502 ◽

Cited By ~ 7

Author(s):

Fikret Berkes ◽

Dorothy Pocock

Keyword(s):

Case History ◽

Lake Erie ◽

History Of ◽

Quota Management

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On Haslanger’s Meta-Metaphysics: Social Structures and Metaphysical Deflationism

Disputatio ◽

10.2478/disp-2018-0013 ◽

2018 ◽

Vol 10 (50) ◽

pp. 201-216

Author(s):

E. Díaz-León

Keyword(s):

Social Structures ◽

Gender And Race ◽

Area Of Concern ◽

Analytic Metaphysics

Abstract The metaphysics of gender and race is a growing area of concern in contemporary analytic metaphysics, with many different views about the nature of gender and race being submitted and discussed. But what are these debates about? What questions are these accounts trying to answer? And is there real disagreement between advocates of differ- ent views about race or gender? If so, what are they really disagreeing about? In this paper I want to develop a view about what the debates in the metaphysics of gender and race are about, namely, a version of metaphysical deflationism, according to which these debates are about how we actually use or should use the terms ‘gender’ and ‘race’ (and other related terms), where moral and political considerations play a central role. I will also argue that my version of the view can overcome some recent and powerful objections to metaphysical deflationism of- fered by Elizabeth Barnes (2014, 2017).

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