Effect of negative pressure therapy on repair of soft tissues of the lower extremities in patients with neuropathic and neuroischaemic forms of diabetic foot syndrome

Aim. To evaluate the efficiency of topical negative pressure wound therapy (NPWT) compared with standard therapy for the regeneration of the soft tissues of the lower extremities in patients with diabetic foot syndrome. Materials and Methods. The effects of negative pressure therapy on the clinical (size, tissue oxygenation), histological (light microscopy) and immunohistochemical (CD68, MMP-9, TIMP-1) aspects of repair of the soft tissue of the lower extremities in patients with diabetes mellitus were compared with those of standard treatment. Thirty-one patients with diabetic foot ulcers were included in the study from the moment of debridement until the plastic closure of the wound. During the perioperative period, 13 patients received NPWT (-90 to -120 mmHg) and 18 patients received standard therapy. Results. A reduction of the wound area (26.6%?17.2%) and the depth of the defects (40.5%?25.6%) were achieved with negative pressure therapy compared with baseline data. In the control group, the corresponding values were 25.3%?19.4% and 21.8%?21.6%, respectively. The results of transcutaneous oximetry showed a greater increase in the level of local hemodynamics in the study group (p

Download Full-text

Negative Pressure Therapy in the Surgical Treatment of Diabetic Foot

Revista de Chimie ◽

10.37358/rc.17.7.5736 ◽

2017 ◽

Vol 68 (7) ◽

pp. 1648-1651

Author(s):

Bogdan Mihnea Ciuntu ◽

Ciprian Vasiluta ◽

Robert Negru ◽

Roxana Hultoana ◽

Roxana Ciuntu ◽

...

Keyword(s):

Abdominal Wall ◽

Negative Pressure ◽

Diabetic Foot ◽

Bacterial Load ◽

Abdominal Wall Defects ◽

Negative Pressure Therapy ◽

Simultaneous Application ◽

Average Hospital ◽

Pressure Therapy ◽

Days Of Therapy

The study aims to assess the significance of negative pressure therapy in the treatment of diabetic foot.The objectives intend to evaluate the healing time required after applying the method and the functional consequences for the patient. A prospective study was conducted on a sample of 37 patients with diabetic foot were monitored their clinical course between September 2014 - April 2017, following negative pressure therapy. There were used vacuum assisted closure devices (VAC � -Hartman) in order to apply negative pressure to the wound, while complying with specified settings (negative pressure, time of use of a kit) in accordance with patients� outcome.There were monitored changes in wound size (planimetric and volumetric measurement), their bacterial load and duration of treatment. Healing was obtained in all cases, to an average hospital stay of 27.3 days and 8 days of therapy application.The negative result of microbial cultures was obtained after an average of 6.45 days by simultaneous application of negative pressure and antibiotic treatment according to the antibiogram. Skin grafts were necessary to close the defect in 4 cases. After basic treatment of the wound, auxiliary methods such as negative pressure contribute to the healing.In patients with diabetic foot who were required surgical intervention, the use of negative pressure therapy yielded a significant benefit in the preservation of the affected limb, after minimal excision.The results we obtained throughout our experience recommend use of NPTW technique as indication for abdominal wall surgery in closing abdominal wall defects, compartment syndrome and surgical site infection after prosthetic mesh.

Download Full-text

Negative pressure therapy in diabetic foot wounds

The Lancet ◽

10.1016/s0140-6736(06)68295-0 ◽

2006 ◽

Vol 367 (9512) ◽

pp. 726 ◽

Cited By ~ 3

Author(s):

Ernst Chantelau

Keyword(s):

Negative Pressure ◽

Diabetic Foot ◽

Negative Pressure Therapy ◽

Pressure Therapy

Download Full-text

Nurse Approach in the Treatment of Piabetic Foot Ulcers with the Management of Negative Pressure Therapy

10.47363/jdrr/2020(3)119 ◽

2021 ◽

pp. 1-4

Author(s):

Astasio Picado Álvaro ◽

Keyword(s):

Negative Pressure ◽

Diabetic Foot ◽

Bacterial Load ◽

Foot Ulcers ◽

Diabetic Foot Ulcers ◽

Negative Pressure Therapy ◽

Novel Therapy ◽

Pressure Therapy ◽

Advanced Therapy ◽

Global Increase

The global increase of Diabetes Mellitus represents serious complications for those who suffer from it, the most frequent complications are diabetic foot ulcers and amputations derived from them. Currently, negative pressure therapy (NPT) is used as an advanced therapy for the treatment of this type of ulcers. This novel therapy promises numerous advantages for the nursing approach to patients with diabetic foot ulcers. Therefore, the objective of this narrative review is to prove the effectiveness of the negative pressure therapy as a treatment for diabetic foot ulcers. The search of the articles was carried out in several scientific databases with the help of a searching chain, which combined the keywords and boolean operators. 16 studies were selected, which indicated that NPT as a treatment for diabetic foot ulcers provides benefits such as promoting the formation of granulation tissue, healing and closing of the ulcer in a shorter time, as well as reducing ulcer depth and area and even decreases the bacterial load, the rate of amputations and reulcerations. Hence, NPT is an effective therapy that should be applied to clinical practice

Download Full-text

Negative pressure therapy in diabetic foot wounds – Authors' reply

The Lancet ◽

10.1016/s0140-6736(06)68296-2 ◽

2006 ◽

Vol 367 (9512) ◽

pp. 726-727 ◽

Cited By ~ 3

Author(s):

David G Armstrong ◽

Lawrence A Lavery

Keyword(s):

Negative Pressure ◽

Diabetic Foot ◽

Negative Pressure Therapy ◽

Pressure Therapy

Download Full-text

Bubbling Treatment Option in the Complex Therapy of Diabetic Foot Syndrome

Vestnik of Experimental and Clinical Surgery ◽

10.18499/2070-478x-2021-14-3-210-215 ◽

2021 ◽

Vol 14 (3) ◽

pp. 210-215

Author(s):

Anton Petrovich Ostroushko ◽

Alexander Alekseevich Andreev ◽

Alexander Alexandrovich Shmarin ◽

Vladislav Valeryevich Novomlinsky ◽

Anastasia Yurievna Laptiyova ◽

...

Keyword(s):

Treatment Option ◽

Diabetic Foot ◽

Soft Tissues ◽

Treatment Method ◽

Late Complications ◽

Diabetic Foot Syndrome ◽

Control Group ◽

Results Of Treatment ◽

Patients With Diabetes ◽

After Cancer

Diabetes mellitus (DM) is the most common and socially significant endocrine disease that leads to early disability and is the most common cause of mortality in patients after cancer and cardiovascular pathology. The cost of managing patients with diabetes can reach 30% of the country's health budget, 90% of which is spent on the treatment of its complications. Diabetic foot syndrome (DFS) is developed in 20-80% of patients and is one of the most dangerous late complications. In clinical practice, various approaches to its treatment are used, but the number of high amputation and mortality rate in this group of patients remains significant. The aim of the study was to improve the results of treatment of patients with diabetic foot syndrome (DFS) by including the bubbling treatment method in the program of therapeutic measures. Forty-eight patients with neuropathic and neuroischemic forms of DFS were treated. The control group consisted of 23 patients receiving conventional treatment, the main group included 26 patients, who were applied bubbling treatment option locally. The analysis of groups of patients showed no significant differences by gender, age, stages of diabetic foot syndrome, depth of necrotic defect, complications and concomitant diseases. The use of the bubbling treatment method in the complex treatment of patients with DFS allowed more effectively arresting symptoms of local (edema, hyperemia, wound exudate, necrolysis) and general inflammation, anemia and intoxication syndromes, contributed to the activation of regeneration processes in soft tissues, which, combined with complex FDS treatment, together, reduced the number of amputations by 18.7%.

Download Full-text

Prostaglandin E1 in vascular reconstructive operations in patients with diabetic foot syndrome

Kazan medical journal ◽

10.17816/kmj2340 ◽

2012 ◽

Vol 93 (2) ◽

pp. 370-371

Author(s):

K A Koreyba ◽

A V Maksimov

Keyword(s):

Blood Vessels ◽

Diabetic Foot ◽

Prostaglandin E1 ◽

Lower Extremities ◽

Perioperative Period ◽

Diabetic Foot Syndrome ◽

Reconstructive Operations

The article presents the results of using prostaglandin E1 in the perioperative period in patients with diabetic foot syndrome who underwent reconstructive operations on the blood vessels of the lower extremities. This method made it possible to optimize the treatment of this group of patient.

Download Full-text