ACTH-producing medullary thyroid cancer. Clinical case.

2016 ◽  
Vol 62 (4) ◽  
pp. 45-49
Author(s):  
Evgenia I. Marova ◽  
Ludmila Ya. Rozhinskaya ◽  
Iya A. Voronkova ◽  
Oleg V. Remizov ◽  
Anna I. Zavalishina ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Clinical Picture ◽  
Clinical Case ◽  
Medullary Thyroid Cancer ◽  
Diagnostic Errors ◽  
Ectopic Acth Syndrome ◽  
Ectopic Acth ◽  
Medullary Thyroid ◽  
Ectopic Acth Production

Medullary thyroid cancer with ectopic ACTH production - the disease is extremely rare. The literature describes only a few cases of this disease. Rare ectopic ACTH syndrome caused by medullary thyroid cancer, and the diversity of the clinical picture are responsible for numerous diagnostic errors leading to ineffective treatment. In this regard, we consider it expedient to share our own experience in this area.

Ectopic ACTH-Mediated Cushing Syndrome (CS) from Sporadic Medullary Thyroid Cancer (MTC): An Immunohistochemical (IHC) Confirmation Study

2011 ◽  
pp. P3-66-P3-66
Author(s):  
Venkata G Budharaju ◽  
James R Howe ◽  
Patricia Kirby ◽  
Robert A Robinson ◽  
Kalman Kovacs ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Medullary Thyroid Cancer ◽  
Cushing Syndrome ◽  
Ectopic Acth ◽  
Medullary Thyroid

scholarly journals ACTH-secreting medullary thyroid cancer: a case series

2017 ◽  
Vol 2017 ◽  
Author(s):  
Ayanthi A Wijewardene ◽  
Sarah J Glastras ◽  
Diana L Learoyd ◽  
Bruce G Robinson ◽  
Venessa H M Tsang
Keyword(s):  
Thyroid Cancer ◽  
Cushing’S Syndrome ◽  
Medullary Thyroid Cancer ◽  
Kinase Inhibitors ◽  
Neuroendocrine Tumour ◽  
Therapeutic Option ◽  
Rare Complication ◽  
Cushing's Syndrome ◽  
Ectopic Acth ◽  
Medullary Thyroid

Summary Medullary thyroid cancer (MTC) is a rare neuroendocrine tumour that originates from the parafollicular cells of the thyroid gland. The most common presentation of MTC is with a single nodule; however, by the time of diagnosis, most have spread to the surrounding cervical lymph nodes. Cushing’s syndrome is a rare complication of MTC and is due to ectopic adrenocorticotrophic hormone (ACTH) secretion by tumour cells. Cushing’s syndrome presents a challenging diagnostic and management issue in patients with MTC. Tyrosine kinase inhibitors (TKI) previously used for the management of metastatic MTC have become an important therapeutic option for the management of ectopic ACTH in metastatic MTC. The article describes three cases of ectopic ACTH secretion in MTC and addresses the significant diagnostic and management challenges related to Cushing’s syndrome in metastatic MTC. Learning points: Medullary thyroid cancer (MTC) is a rare neuroendocrine tumour. Cushing’s syndrome is a rare complication of MTC that has a significant impact on patients’ morbidity and mortality. Tyrosine kinase inhibitors (TKI) provide an important therapeutic option for the management of ectopic ACTH in metastatic MTC.

scholarly journals Medullary Thyroid Cancer Metastatic to the Oral Cavity: Clinical Case

2019 ◽  
Vol 16 (1) ◽  
Author(s):  
Luis Cruz-Benítez ◽  
Angélica Julián-Castrejón ◽  
Juan de Dios Pérez-Reyna
Keyword(s):  
Thyroid Cancer ◽  
Oral Cavity ◽  
Clinical Case ◽  
Medullary Thyroid Cancer ◽  
Medullary Thyroid

scholarly journals Bilateral Pheochromocytoma and Medullary Thyroid Cancer

2017 ◽  
Vol 10 (3) ◽  
pp. 201-206
Author(s):  
Vyacheslav Petrovich Zemlyanoy ◽  
Aleksandr Aleksandrovich Lisitsyn ◽  
Mikhail Mikhailovich Nakhumov ◽  
Evgeniya Mikhailovna Nesvit
Keyword(s):  
Thyroid Cancer ◽  
Genetic Screening ◽  
Clinical Case ◽  
Medullary Thyroid Cancer ◽  
Genetic Research ◽  
Medullary Thyroid ◽  
Men 2 ◽  
Bilateral Pheochromocytoma ◽  
Comprehensive Examination ◽  
High Concordance

Introduction: Pheochromocytoma is one of representative of neuroendocrine tumors. According this fact, pheochromocytoma remains to evaluation for multiply endocrine neoplasia, especially if disease is bilateral. In this case, it is necessary to additionally carry out a genetic screening test. The aim of the study is to Improve diagnosis and treatment outcomes for patients with MEN syndrome. Materials and methods: The authors present a clinical case of a 37-year-old man diagnosed and treated for a bilateral pheochromocytoma. Results: The patient was diagnosed medullary thyroid cancer after successful bilateral adrenalectomy. The patient underwent thyroidectomy. A genetic research showed the T1900 mutation in the codon of 634 RET gene, which confirmed the presence of the patient MEN 2 syndrome. According to the high concordance of the mutated gene, patient's son was carried out to genetic examinations, which confirmed the presence of this mutation. The boy underwent thyroidectomy opportunely. Discussion: Due to primary oncological observation if the patient has pheochromacytoma, it is necessary to exclude MAN 2 syndrome both in the patient himself and his relatives. The safest and informative method is genetic research. Conclusion: presently a comprehensive examination of both the patient himself and his relatives is necessary for timely diagnosis and correct management of treatment patients with MEN 2 syndrome.

Adrenocortical Ultrastructure in Ectopic Acth Syndrome

1976 ◽  
Vol 34 ◽  
pp. 238-239
Author(s):  
K. Kovacs ◽  
E. Horvath ◽  
W. Singer
Keyword(s):  
Adrenal Cortex ◽  
Zona Glomerulosa ◽  
Ectopic Acth Syndrome ◽  
Pituitary Neoplasms ◽  
Electron Microscopic ◽  
Adrenocortical Cells ◽  
Cell Hyperplasia ◽  
Ectopic Acth ◽  
Ectopic Acth Production ◽  
Microscopic Findings

Secretion of ACTH by non-pituitary neoplasms is recognized with increasing frequency. While the clinical and biochemical changes associated with ectopic ACTH production have been extensively studied recently, relatively little attention was focused on the morphology of the adrenal cortex and, to our knowledge, the fine structure of the adrenocortical cells in cases of ectopic ACTH syndrome has not been described so far. We report here the electron microscopic findings in the adrenal cortex of a 50-year-old man with a pancreatic apudoma. The patient showed the characteristic clinical and biochemical features of ectopic ACTH syndrome and because of extensive hypercorticism, underwent bilateral adrenalectomy.By light microscopy, the adrenal cortices showed extensive compact cell hyperplasia and lipid depletion. The zona glomerulosa was present in small foci and, except for a few places, fasciculata cells were noted under the fibrous capsule.

Abstract #1101 The Value of Calcitonin Calcium Stimulation Test Levels as Predictors of Medullary Thyroid Cancer.

2018 ◽  
Vol 24 ◽  
pp. 273-274
Author(s):  
Corin Badiu ◽  
Mara Baet ◽  
Ruxandra Dobrescu ◽  
Andra Caragheorgheopol ◽  
Corneci Cristina
Keyword(s):  
Thyroid Cancer ◽  
Medullary Thyroid Cancer ◽  
Stimulation Test ◽  
Medullary Thyroid ◽  
Calcium Stimulation

Immunoscintigraphy in Medullary Thyroid Cancer Using an 123I- or 111ln-Labelled Monoclonal Anti-CEA Antibody Fragment

1986 ◽  
Vol 25 (06) ◽  
pp. 227-231 ◽  
Author(s):  
Chr. Eilles ◽  
W. Spiegel ◽  
W. Becker ◽  
W. Börner ◽  
Chr. Reiners
Keyword(s):  
Bone Marrow ◽  
Thyroid Cancer ◽  
Potassium Iodide ◽  
Medullary Thyroid Cancer ◽  
Elevated Serum ◽  
Antibody Fragment ◽  
Special Importance ◽  
Medullary Thyroid ◽  
Medullary Cancer ◽  
Serum Cea

The monoclonal anti-CEA F(ab’)2 fragment MAb BW 431/31, labelled with 123I or111 In, was used for immunoscintigraphy (IS) in 9 patients with medullary cancer of the thyroid (CCC). The results of 11 studies lead to the following conclusions: 1) When using radioiodine as a label for MAb in IS, potassium iodide is absolutely necessary to block the thyroid which is of special importance in patients with thyroid cancer; 2) Preinjection of “cold” MAb reduces the relatively high unspecific uptake (especially in bone marrow) of MAb BW 431/31, which is of special importance for the antibody labelled with 111 In; 3) IS with MAb BW 413/31 in patients with CCC and elevated serum CEA is positive only in cases with large secondaries; and 4) In patients with CCC and several manifestations of secondaries, only a single (large) metastasis may be apparent.

NTRK3 receptor expression is strictly associated with medullary thyroid cancer RET mutation status

2014 ◽  
Author(s):  
Malgorzata Oczko-Wojciechowska ◽  
Michal Swierniak ◽  
Malgorzata Kowalska ◽  
Agnieszka Pawlaczek ◽  
Monika Kowal ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Medullary Thyroid Cancer ◽  
Receptor Expression ◽  
Mutation Status ◽  
Medullary Thyroid ◽  
Ret Mutation
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