Formulation and Evaluation of Throat Paint of Erythromycin Estolate

The research work was aimed at developing and optimizing erythromycin estolate throat paint solution for improved bioavailability in the oral delivery of based throat paint is prepared by unique method. Potassium iodide, glycerol has been selected based on mouth paint, mucoadhesive strength, and the drug the medication with the goal of treating wooping cough. Erythromycin estolateis released in vitro. A 32factorial prototype was used to preparation the throat paint at concentration of potassium iodide and glycerol was used as an independent variable released in vitro and permeated by percentage.For throat paint, the percentage of mucoadhesion, product consistency,releaseof drugs in vitro, and percentage of rest from permeation were calculated. With mucoadhesive strength, percentage permeation and in-vitro drug releaseperformance, formula f9 has been optimized. Studies of FTIR and have characterised throat paint. Study of stability revealed stable formulation was found.

Effect of Sodium Fluoride Varnish and Potassium Iodide on Remineralization Efficacy of Silver Diamine Fluoride

The purpose of this study was to compare the effect of sodium fluoride(NaF) varnish and potassium iodide(KI) on remineralization efficacy of silver diamine fluoride(SDF) by measuring microhardness and evaluating surface morphology by scanning electron microscope(SEM). Artificial caries lesions were induced on extracted primary molars and vickers microhardness was measured. Specimens were randomly separated into 4 groups for treatment. The specimens in group I were treated with SDF, group II with NaF varnish after SDF, group III with KI after SDF and group IV with distilled water. After 8 days of pH cycling, vickers microhardness was measured and difference before and after treatment was calculated. For SEM, 2 samples were evaluated respectively after enamel polishing, lesion formation and after pH cycling. Group III showed highest increase in microhardness. Group I showed higher increase in microhardness than Group II but without statistical difference. Group IV showed lowest increase in microhardness value among 4 groups. On SEM image, group I, II and III showed smoother and less irregular surface compared to group IV. Amorphous crystal pellicles were observed in group III. In conclusion, SDF, SDF and NaF, SDF and KI groups showed smoother surface and increase in microhardness suggesting the possibility that remineralization effect might take place in oral conditions. In addition, in limited conditions of this study, applying NaF varnish after SDF did not increase the remineralization efficacy of SDF while KI significantly increased the remineralization efficacy of SDF. However, additional study considering various conditions that might affect demineralization and remineralization in clinical situations need to be conducted.