14 alfa Esterol Demetilasa de Rhizopus arrhizus (syn. Rhizopus oryzae): participación en la Resistencia Natural a Voriconazol

Treze táxons de Mucorales (Zygomycotina), distribuídos num total de 266 registros, foram isolados de folhas de Alchornea triplinervia (Spreng.) Müll. Arg. colocadas em ambientes terrestre e aquático, e de amostras de solo e de água de riacho, coletadas mensalmente, de julho de 1988 a maio de 1990 na Reserva Biológica do Alto da Serra de Paranapiacaba, no município de Santo André, SP. As espécies que apresentaram os maiores números de registro de ocorrência foram Mucor hiemalis Wehmer (78 registros), Mucor circinelloides van Tieghem f. janssenii (Ledner) Schipper (42 registros) e Rhizopus arrhizus Fischer (30 registros). Cinqüenta por cento dos Mucorales encontrados na região são constituídos por espécies que estão sendo citadas pela primeira vez para a Mata Atlântica: Mucor hiemalis Wehmer f. silvaticus (Hagem) Schipper, Rhizopus arrhizus Fischer, Rhizopus oligosporus Fischer, Rhizopus oryzae (Went. & Prinsen) Geerlings, Zygorhynchus japonicus Vuill. e Zygorhynchns macrocarpus Ling-Young.

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Case Report: Coronavirus Disease 2019-associated Rhinosinusitis Mucormycosis Caused by Rhizopus arrhizus: A Rare but Potentially Fatal Infection Occurring After Treatment with Corticosteroids

American Journal of Tropical Medicine and Hygiene ◽

10.4269/ajtmh.21-0359 ◽

2021 ◽

Author(s):

Payam Tabarsi ◽

Neda Khalili ◽

Mihan Pourabdollah ◽

Somayeh Sharifynia ◽

Ali Safavi Naeini ◽

...

Keyword(s):

Rhizopus Oryzae ◽

Fungal Infections ◽

Invasive Pulmonary Aspergillosis ◽

Rhizopus Arrhizus ◽

Limited Information ◽

Internal Transcribed Spacer Region ◽

Systemic Corticosteroids ◽

Uncontrolled Diabetes ◽

Facial Swelling

Coronavirus disease 2019 (COVID-19) first emerged in Wuhan, China, in December 2019. Since that time, the frequency of bacterial and fungal coinfections has been continuously increasing. Although invasive pulmonary aspergillosis is being increasingly recognized in association with COVID-19, there is limited information regarding COVID-19-associated mucormycosis. We describe a 50-year-old woman with uncontrolled diabetes who received systemic corticosteroids and remdesevir during her admission for COVID-19. A few days after discharge, the patient was readmitted because of facial swelling and numbness, and a diagnosis of COVID-19-associated rhinosinusitis mucormycosis caused by Rhizopus arrhizus (formerly called Rhizopus oryzae) was confirmed with sequencing of the internal transcribed spacer region of the ribosomal DNA. This report aimed to address the importance of short-term follow-up for COVID-19 patients who have received systemic corticosteroids, particularly those with predisposing conditions, because early detection and prompt, aggressive treatment are essential for the management of invasive fungal infections.

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Development and Evaluation of an Immunodiffusion Test for Diagnosis of Systemic Zygomycosis (Mucormycosis): Preliminary Report

Journal of Clinical Microbiology ◽

10.1128/jcm.7.1.97-101.1978 ◽

1978 ◽

Vol 7 (1) ◽

pp. 97-101 ◽

Cited By ~ 1

Author(s):

Kenneth W. Jones ◽

Leo Kaufman

Keyword(s):

Preliminary Report ◽

Rhizopus Oryzae ◽

Rhizopus Arrhizus ◽

Promising Technique ◽

Absidia Corymbifera ◽

Immunodiffusion Test ◽

Study Results ◽

Common Antigens

An antigen analysis with filtrate and homogenate precipitinogens of single isolates of the zygomycetes Absidia corymbifera, Mucor pusillus, Rhizopus arrhizus , and Rhizopus oryzae demonstrated the presence of common antigens among the three genera as well as antigens which permit their differentiation. Selected homogenate antigens were valuable in developing a diagnostic immunodiffusion (ID) test for systemic zygomycosis. When sera from 43 patients with various proven mycoses other than zygomycosis were tested against each of the antigens, none formed precipitin bands identical to those formed by A. cormybifera, M. pusillus , and the Rhizopus spp. rabbit reference antisera. Sera from 23 normal persons and 25 diabetics did not react with any of the antigens. Homogenate antigens detected antibody in 8 of the 11 sera (73%) from suspected or proven cases of zygomycosis, whereas ID tests with filtrate antigens detected antibody in only 2 of the 11 sera (18%). Of the eight sera that reacted with the homogenate antigens, five only reacted with a specific Rhizopus sp. antigen, two only reacted with a specific M. pusillus antigen, and one only reacted with a specific A. corymbifera antigen. Study results show the ID test with homogenate antigens to be more specific and sensitive than the ID test with filtrate antigens and indicate that the former is a promising technique for diagnosing human zygomycosis.

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COVID-19 associated rhinosinusitis mucormycosis due to Rhizopus arrhizus: A rare but potentially fatal infection occurring after treatment with corticosteroids

10.21203/rs.3.rs-398594/v2 ◽

2021 ◽

Author(s):

Payam Tabarsi ◽

Neda Khalili ◽

Mihan Pourabdollah ◽

Somayeh Sharifynia ◽

Ali Safavi Naeini ◽

...

Keyword(s):

Rhizopus Oryzae ◽

Fungal Infections ◽

Invasive Pulmonary Aspergillosis ◽

Its Region ◽

Rhizopus Arrhizus ◽

Limited Information ◽

Systemic Corticosteroids ◽

Uncontrolled Diabetes ◽

Facial Swelling

Abstract Coronavirus disease 2019 (COVID-19) first emerged in Wuhan, China in December 2019, and since then the frequency of bacterial and fungal coinfections has been continuously rising. While invasive pulmonary aspergillosis is increasingly being recognized in association with COVID-19, there is limited information with regards to COVID-19 associated mucormycosis. Here, we describe a 50-year-old woman with uncontrolled diabetes who received systemic corticosteroids and remdesevir during her admission for COVID-19. Few days after discharge, the patient was readmitted due to facial swelling and numbness, and a diagnosis of COVID-19 associated rhinosinusitis mucormycosis due to Rhizopus arrhizus (formerly Rhizopus oryzae) was confirmed with sequencing of the internal transcribed spacer (ITS) region of the ribosomal DNA. This report aims to address the importance of short-term follow-up in COVID-19 patients who have received systemic corticosteroids, particularly those with predisposing conditions, as early detection and prompt, aggressive treatment is essential for the management of invasive fungal infections.

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Pyogranulomatous obliterative laryngotracheitis by Rhizopus arrhizus (syn. R. oryzae) in a free-ranging Atlantic spotted dolphin Stenella frontalis

Diseases of Aquatic Organisms ◽

10.3354/dao03268 ◽

2018 ◽

Vol 130 (2) ◽

pp. 153-158

Author(s):

A Cerezo ◽

O Quesada-Canales ◽

E Sierra ◽

J Díaz-Delgado ◽

A Fernández ◽

...

Keyword(s):

Rhizopus Arrhizus ◽

Stenella Frontalis ◽

Spotted Dolphin ◽

Free Ranging

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Case of a diabetic man cured from rhinocerebral zygomycosis

Orvosi Hetilap ◽

10.1556/oh.2010.28969 ◽

2010 ◽

Vol 151 (39) ◽

pp. 1591-1596

Author(s):

Botond Lakatos ◽

Radka Nikolova ◽

László Ocskay ◽

Judit Csomor ◽

Gyula Prinz

Keyword(s):

Staphylococcus Aureus ◽

Pseudomonas Aeruginosa ◽

Amphotericin B ◽

Rhizopus Oryzae

A zygomycosis (mucormycosis) ritka, kifejezetten agresszív lefolyású opportunista infekció, amelyet a Zygomycota (Járomspórás gombák) törzs Zygomycetes osztályába tartozó gombák okoznak. Jellemzően immunhiány, neutropenia, vastúlterhelés, hematológiai betegség, illetve diabeteses ketoacidosis eseteiben fordul elő. Esetismertetés: A szerzők 18 éves, 9 éve inzulindependens diabetes mellitusban szenvedő, rossz compliance-szel rendelkező beteg kórtörténetét ismertetik. Súlyos állapotban, beszűkült tudattal, ketoacidosisban, orrmelléküreg-gyulladásra utaló egyoldali periorbitalis duzzanattal, bőrpírral került kórházba. Bár az endoszkópos sinusműtét során vett váladékból methicillinrezisztens Staphylococcus aureus és Pseudomonas aeruginosa tenyészett, a beteg anamnézise, klinikuma zygomycosis gyanúját keltette, emiatt amphotericin-B-kezelést indítottak. Szövettani, illetve mikrobiológiai vizsgálatok során Rhizopus oryzae okozta invazív infekció igazolódott. Megbeszélés: Az antifungális kezelés ismételt sebészeti beavatkozásokkal és adjuváns granulocytakolónia-stimuláló faktor alkalmazásával kiegészítve eredményesnek bizonyult. A beteg négy hónappal hazabocsátását követően él és panaszmentes. Orv. Hetil., 2010, 39, 1591–1596.

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