PAGET'S DISEASE: CURRENT TREATMENT MODALITIES

Abstract Background Worldwide, breast cancer comprises 10.4% of all cancer incidences among women, making it the second most common type of non-skin cancer (after lung cancer) and the fifth most common cause of cancer death. In 2004, breast cancer caused 519,000 deaths worldwide (7% of cancer deaths; almost 1% of all deaths). Breast cancer is about 100 times more common in women than in men, although males tend to have poorer outcomes due to delays in diagnosis. Aim of the Work To clarify clinical, pathological features and outcomes of the treatment modalities for Paget’s disease of the breast at Ain Shams University Hospitals. Materials and Methods Our study was held as a retrospective cohort study to clarify clinical, pathological features and outcomes of the treatment modalities for Paget’s disease of the breast at Ain Shams University Hospitals. Results At Ain Shams university hospitals patients having pagetoid cells by biopsy and no mass radiologically underwent simple mastectomy and if pathology proved any malignancy in breast tissue axillary clearance was done and might be followed by radiotherapy. Conclusion Patients having pagetoid cells by biopsy and a mass radiologically which is invasive or insitu with microinvasion will undergo modified radical mastectomy and may be followed by radiotherapy. But if pagetoid cells and mass radiologically which is in situ simple mastectomy will be done.

Download Full-text

Management of Lichen Sclerosus and Intraepithelial Neoplasia of the Vulva in the UK

Journal of the Royal Society of Medicine ◽

10.1177/014107689608901211 ◽

1996 ◽

Vol 89 (12) ◽

pp. 699-701 ◽

Cited By ~ 11

Author(s):

J A Tidy ◽

W P Soutter ◽

D M Luesley ◽

A B MacLean ◽

C H Buckley ◽

...

Keyword(s):

Paget’S Disease ◽

Lichen Sclerosus ◽

Great Majority ◽

Intraepithelial Neoplasia ◽

Postal Questionnaire ◽

Paget's Disease ◽

Treatment Modalities ◽

Topical Steroids ◽

Senior Registrar ◽

The Uk

Women with vulval intraepithelial neoplasia (VIN), lichen sclerosus (LS) and Paget's disease are referred either to gynaecologists or to dermatologists. We have ascertained the caseloads, referral patterns and treatment modalities used in the two specialties. A postal questionnaire was sent to 540 consultant gynaecologists and 225 consultant and senior registrar members of the British Association of Dermatologists. 350 gynaecologists and 161 dermatologists returned completed questionnaires. The workload of LS and Paget's disease was evenly distributed, with 54% of dermatologists and 58% of gynaecologists seeing more than six cases of LS per annum and less than 1% seeing more than five cases of Paget's disease. 92% of responding gynaecologists saw at least one case of VIN per year whereas 43% of dermatologists saw no cases. Patients with VIN and Paget's were referred to gynaecologists for treatment by 66% of dermatologists. Both groups are equally prepared to treat LS. Indications for treatment of VIN and LS were suspicion of invasion and symptoms. Local excision of VIN is the treatment of choice by both gynaecologists and dermatologists. LS is predominantly treated with topical steroids but gynaecologists also use topical oestrogen and testosterone. The great majority of responders favoured establishing a national register to study the outcome of vulval lesions.

Download Full-text