Squamous cell carcinoma (SCC) of the renal pelvis following chronic nephrolithiasis; presented with feature suggesting  xanthogranulomatous pyelonephritis

Background: Squamous cell carcinoma (SCC) which originated in the urothelium of the urological system is not uncommon; however, it is rare in the renal pelvis. Additionally, it is hard to be diagnosed without high clinical suspicion.Case summary: A-66-years old female presented with left loin pain for 6 years, hematuria, and fever for months. Examination revealed no abnormality apart from pallor and bimanually palpable left kidney. Her investigations showed normal renal function and anemia, Computer Topography for Kidney, Ureter, and Bladder (CT-KUB) revealed a large left renal pelvic stone with a hugely enlarged kidney with suspicion of xanthogranulomatous pyelonephritis (XGPN), with almost absent function of the left kidney in DTPA. She underwent Left trans-peritoneal radical nephrectomy. Post-operative histopathology result was moderately differentiated squamous cell carcinoma (T3, N0, M0). To our knowledge this was the first reported case in our hospital, we think that the treatment was fair putting in mind the poor prognosis of the condition and the difficulty in diagnosis.Conclusion: This case demonstrates renal pelvis SCC presented with radiological features suggestive of xanthogranulomatous pyelonephritis.

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Primary squamous cell carcinoma of renal pelvis and kidney- Sole diagnosis by histopathology

IP Journal of Diagnostic Pathology and Oncology ◽

10.18231/j.jdpo.2021.052 ◽

2021 ◽

Vol 6 (3) ◽

pp. 242-244

Author(s):

Prachi ◽

Gaurav Sharma ◽

Vikas Jain

Keyword(s):

Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Squamous Cell ◽

Renal Pelvis ◽

Obstructive Uropathy ◽

Squamous Metaplasia ◽

Left Kidney ◽

Xanthogranulomatous Pyelonephritis ◽

Renal Neoplasm ◽

Primary Squamous Cell Carcinoma

Primary Squamous cell carcinoma of the renal pelvis is rare and accounts to only 0.5- 0.8 % of malignant renal tumours having poor prognosis. Chronic irritation, inflammation and infection induce the pathogenesis of this malignancy. A 53 year old male patient, presented with left flank pain since one month. On radiological investigation, his CT revealed atrophic shrunken left kidney measuring 7.9x5.2cms showing significant parenchymal thinning and complete loss of corticomedullary differentiation. A left upper ureteric calculus is seen measuring 7.5 mm with significant left renal hydronephrosis.Clinically, it was diagnosed as Xanthogranulomatous Pyelonephritis. Grossly the radical nephrectomy specimen measures 10.5x5.5x3.5cm. External surface is irregular & bosselated. On Cut surface renal architecture is effaced by necrotic mass measuring 9.5x5.0x3.0 cm involving pelvic ureter and most of renal parenchyma.Hematoxylin and eosin stained tissue revealed characteristic feature such as keratin pearls and intracellular bridges seen, rendering the diagnosis of well-differentiated keratinising squmaous cell carcinoma seen with 40% tumour necrosis associated with Keratinizing Squamous Dysplasia. In the present case, obstructive uropathy has triggered the event of malignancy. The radiologic differential diagnosis includes primary and secondary renal neoplasms and xanthogranulomatous pyelonephritis associated with renal calculi. XGP is commonly associated with lithiasis however, rarely causes keratinizing squamous metaplasia and its manifestations closely mimic renal neoplasm, leading to misdiagnosis of malignancy.The prognosis is dismal with a 5-year survival rate of <10%. CT and MRI play a crucial role in diagnosis and staging of these tumors, though histology always remains confirmatory and diagnostic.

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Case report of primary renal pelvis squamous cell carcinoma coexisting with long-standing calculi in left kidney on 18F-FDG PET/CT

Medicine ◽

10.1097/md.0000000000006341 ◽

2017 ◽

Vol 96 (11) ◽

pp. e6341 ◽

Cited By ~ 4

Author(s):

Shengming Deng ◽

Bin Zhang ◽

Ying Huang ◽

Jihui Li ◽

Shibiao Sang ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Case Report ◽

Cell Carcinoma ◽

Squamous Cell ◽

Renal Pelvis ◽

Fdg Pet ◽

Left Kidney ◽

Pet Ct ◽

18F Fdg ◽

Fdg Pet Ct

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Primary Squamous Cell Carcinoma (SCC) of the renal pelvis: A retrospective study of 14 cases

10.26226/morressier.578f37ffd462b8028d8905c0 ◽

2016 ◽

Author(s):

Ines Saguem

Keyword(s):

Squamous Cell Carcinoma ◽

Retrospective Study ◽

Cell Carcinoma ◽

Squamous Cell ◽

Renal Pelvis ◽

Primary Squamous Cell Carcinoma

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Squamous Cell Carcinoma of Kidney and Its Prognosis: A Case Report and Review of the Literature

Case Reports in Urology ◽

10.1155/2015/469327 ◽

2015 ◽

Vol 2015 ◽

pp. 1-3 ◽

Cited By ~ 1

Author(s):

Tapan Kumar Sahoo ◽

Saroj Kumar Das ◽

Chandraprava Mishra ◽

Ipsita Dhal ◽

Rohani Nayak ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Squamous Cell ◽

Radical Nephrectomy ◽

Advanced Stage ◽

Rare Entity ◽

Primary Squamous Cell Carcinoma ◽

Review Of The Literature ◽

Radiological Features ◽

The Right

Primary squamous cell carcinoma of the renal parenchyma is an extremely rare entity. The diagnosis of squamous cell carcinoma of the renal pelvis is usually unsuspected due to the rarity and inconclusive clinical and radiological features. Most of the patients are diagnosed at an advanced stage and are with poor outcome. Radical nephrectomy is the mainstay of the treatment. We reported a case of squamous cell carcinoma of the kidney in a 50-year-old female who presented with the right sided abdomen pain. The patient was treated with radical nephrectomy.

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