The Stevens-Johnson syndrome and toxic epidermal necrolysis in patients of Vitebsk regional clinical hospital: a retrospective analysis

2017 ◽  
Author(s):  
Lyudmila Vykhrystenko ◽  
Olga Velichansky ◽  
Elena Sidorenko ◽  
Olga Zakharova
Keyword(s):  
Toxic Epidermal Necrolysis ◽  
Retrospective Analysis ◽  
Stevens Johnson Syndrome ◽  
Clinical Hospital ◽  
Johnson Syndrome

scholarly journals Retrospective analysis of Stevens–Johnson syndrome and toxic epidermal necrolysis in 87 Japanese patients – Treatment and outcome

2016 ◽  
Vol 65 (1) ◽  
pp. 74-81 ◽  
Author(s):  
Yumiko Yamane ◽  
Setsuko Matsukura ◽  
Yuko Watanabe ◽  
Yukie Yamaguchi ◽  
Kazuko Nakamura ◽  
...  
Keyword(s):  
Toxic Epidermal Necrolysis ◽  
Retrospective Analysis ◽  
Japanese Patients ◽  
Stevens Johnson Syndrome ◽  
Johnson Syndrome

scholarly journals Retrospective Analysis of Corticosteroid Treatment in Stevens-Johnson Syndrome and/or Toxic Epidermal Necrolysis over a Period of 10 Years in Vajira Hospital, Navamindradhiraj University, Bangkok

2014 ◽  
Vol 2014 ◽  
pp. 1-5 ◽  
Author(s):  
Wanjarus Roongpisuthipong ◽  
Sirikarn Prompongsa ◽  
Theerawut Klangjareonchai
Keyword(s):  
Mortality Rate ◽  
Toxic Epidermal Necrolysis ◽  
Retrospective Analysis ◽  
Average Length ◽  
Secondary Infection ◽  
Corticosteroid Treatment ◽  
Stevens Johnson Syndrome ◽  
High Morbidity ◽  
Johnson Syndrome ◽  
Histological Confirmation

Background. Stevens-Johnson syndrome (SJS) and/or toxic epidermal necrolysis (TEN) are uncommon and life-threatening drug reaction associated with a high morbidity and mortality.Objective. We studied SJS and/or TEN by conducting a retrospective analysis of 87 patients treated during a 10-year period.Methods. We conducted a retrospective review of the records of all patients with a diagnosis of SJS and/or TEN based on clinical features and histological confirmation of SJS and/or TEN was not available at the Department of Medicine, Vajira hospital, Bangkok, Thailand. The data were collected from two groups from 2003 to 2007 and 2008 to 2012.Results. A total of 87 cases of SJS and/or TEN were found, comprising 44 males and 43 females whose mean age was 46.5 years. The average length of stay was 17 days. Antibiotics, anticonvulsants, and allopurinol were the major culprit drugs in both groups. The mean SCORTEN on admission was 2.1 in first the group while 1.7 in second the group. From 2008 to 2012, thirty-nine patients (76.5%) were treated with corticosteroids while only eight patients (22.2%) were treated between 2003 and 2007. The mortality rate declined from 25% from the first group to 13.7% in the second group. Complications between first and second groups had no significant differences.Conclusions. Short-term corticosteroids may contribute to a reduced mortality rate in SJS and/or TEN without increasing secondary infection. Further well-designed studies are required to compare the effect of corticosteroids treatment for SJS and/or TEN.

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