AROCALCIFEROLS: A NEW CLASS OF SIDE-CHAIN ANALOGS OF l,25(OH)2D3

Vitamin D ◽  
1991 ◽  
pp. 165-166
Keyword(s):  
Side Chain ◽  
New Class

Evidence for Impaired Hepatic Vitamin K1 Metabolism in Patients Treated with N-Methyl-Thiotetrazole Cephalosporins

1984 ◽  
Vol 51 (03) ◽  
pp. 358-361 ◽  
Author(s):  
H Bechtold ◽  
K Andrassy ◽  
E Jähnchen ◽  
J Koderisch ◽  
H Koderisch ◽  
...  
Keyword(s):  
Protein C ◽  
Oral Intake ◽  
Bleeding Complications ◽  
Side Chain ◽  
Acute Administration ◽  
Vitamin K1 ◽  
New Class ◽  
Parenteral Alimentation ◽  
Hepatocellular Regeneration ◽  
Echis Carinatus

SummaryIn 8 patients on no oral intake and with parenteral alimentation, administration of cephalosporins with N-methyl-thiotetrazole side chain (moxalactam, cefamandole), was associated with prolongation of prothrombin time, appearance in the circulation of descarboxy-prothrombin (counter immunoelectrophoresis and echis carinatus assay) and diminution of protein C. Acute administration of 10 mg vitamin Ki was followed by the transient appearance of vitamin K1 2,3-epoxide, indicating an impaired hepatocellular regeneration of vitamin K1 from the epoxide. Impaired hepatic vitamin K1 metabolism, tentatively ascribed to the N-methyl-thiotetrazole group, is one (but possibly not the only) cause of bleeding complications and depression of vitamin K1dependent procoagulants in patients treated with the new class of cephalosporins.

A new class of supramolecular liquid crystals derived from azo calix[4]arene functionalized 1,3,4-thiadiazole derivatives

2019 ◽  
Vol 43 (8) ◽  
pp. 3556-3564 ◽  
Author(s):  
Vinay S. Sharma ◽  
Akshara P. Shah ◽  
Anuj S. Sharma
Keyword(s):  
Schiff Base ◽  
Liquid Crystals ◽  
Side Chain ◽  
Alkyl Side Chain ◽  
New Class ◽  
Azo Group ◽  
Thiadiazole Derivatives ◽  
Upper Rim

A new class of bowl-shaped supramolecular liquid crystals (LCs) is described derived from calix[4]arene substituted with 1,3,4-thiadiazole derivatives, inbuilt with Schiff base and ester on the lower rim and with an azo group on the upper rim with an alkyl side chain (–OC3H7, –OC8H17).

A new class of bolaforms bearing sulfobetaine and cationic heads: Synthesis and aggregation properties

2003 ◽  
Vol 81 (8) ◽  
pp. 883-888 ◽  
Author(s):  
Souad Souirti ◽  
Michel Baboulene
Keyword(s):  
Hydrophobic Interactions ◽  
Industrial Applications ◽  
Side Chain ◽  
Electronic Microscopy ◽  
New Class ◽  
New Family ◽  
Hydrophobic Chain ◽  
Convenient Route ◽  
The Relationship ◽  
Cationic Amphiphile

We describe here a convenient route to a new family of bolaforms bearing sulfobetaine and cationic heads, which could be scaled up for industrial applications. Their aggregation modes were studied by measurement of surface tension and by dynamic light scattering and transmission electronic microscopy methods. Grafting a hydrophobic chain onto the cationic head modifies both the surface properties and aggregation. Compared to conventional bolaforms, the relationship between the length of the spacer and the side-chain and the resultant hydrophobic interactions are at the origin of these novel properties. Various models of these molecular associations were proposed.Key words: dissymmetric bolaform, sulfobetaine, cationic amphiphile, aggregation.

scholarly journals Benzyloxycarbonyl-d-Phe-Pro-methoxypropylboroglycine: a novel inhibitor of thrombin with high selectivity containing a neutral side chain at the P1 position

1993 ◽  
Vol 290 (2) ◽  
pp. 309-312 ◽  
Author(s):  
G Claeson ◽  
M Philipp ◽  
E Agner ◽  
M F Scully ◽  
R Metternich ◽  
...  
Keyword(s):  
Blood Clotting ◽  
High Selectivity ◽  
Positive Charge ◽  
Potent Inhibitor ◽  
Serine Proteinase ◽  
Side Chain ◽  
Peptide Bonds ◽  
New Class ◽  
Reduced Toxicity ◽  
Positively Charged

Thrombin, the blood-clotting enzyme, is a serine proteinase with trypsin-like specificity and is able to cleave Arg-Xaa peptide bonds but only in a very limited number of substrates (and sites therein). For the prevention and treatment of thrombosis the control of thrombin activity is a key target, and a variety of synthetic inhibitors have been introduced recently, all of which have a positive charge at the P1 site. We report the synthesis of the first example of a new class of inhibitor containing a neutral side chain at the P1 site, the peptide benzyloxycarbonyl-D-Phe-Pro- methoxypropylboroglycine. The peptide is a potent inhibitor of thrombin [Ki (limiting) = 7 nM] and is highly selective for its target enzyme in respect of other serine proteinases. This may be expected to confer considerable advantage in terms of specificity of action and reduced toxicity over conventional, positively charged, inhibitors.

[[(Aminomethyl)aryl]oxy]acetic acid esters. A new class of high-ceiling diuretics. 2. Modifications of the oxyacetic side chain

1984 ◽  
Vol 27 (12) ◽  
pp. 1587-1596 ◽  
Author(s):  
Jacob J. Plattner ◽  
Anthony K. L. Fung ◽  
Jill R. Smital ◽  
Cheuk Man Lee ◽  
Steven R. Crowley ◽  
...  
Keyword(s):  
Acetic Acid ◽  
Side Chain ◽  
New Class ◽  
Acetic Acid Esters ◽  
Acid Esters

Lathosterol side chain amides—A new class of human lathosterol oxidase inhibitors

Steroids ◽  
2008 ◽  
Vol 73 (3) ◽  
pp. 299-308 ◽  
Author(s):  
Martin Giera ◽  
Delphine Renard ◽  
Florian Plössl ◽  
Franz Bracher
Keyword(s):  
Side Chain ◽  
New Class
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