Discrepancies between Spectral Domain Optical Coherence Tomography and Fluorescein Angiography in Detecting Uveitic Macular Edema

AbstractAIM: To compare spectral-domain optical coherence tomography (SD-OCT) with fluorescein angiography (FA) in detecting macular edema in patients with uveitis and analyse discrepancies in the findings obtained by the two methods. METHODS: The study included 133 eyes from 117 patients with uveitis that had SD-OCT (RTVue-100/ Optovue) and FA (Topcon TRC 50DX) scans performed to detect or rule out macular edema. RESULTS: Macular edema was found in 57 (42.9%) of the 133 surveyed eyes. In 37 eyes (27.8%) macular edema was confirmed by both imaging methods. In 17 eyes (12.8%) macular edema was detected on SD-OCT but not on FA;in 15 eyes of these the edema was diffuse, and in 2 eyes - serous retinal detachment was verified in the macular area. Focal macular edema was detected on FA in three eyes (2.3%) in which SD-OCT showed normal finding. In 76 eyes (57.1%) no pathological changes in the macula were observed on both SD-OCT and FA. Kappa coefficient was 0.675 at p < 0.001. The agreement rate between the two methods calculated using Kendall’s tau-b was 0.693 at p < 0.001. CONCLUSION: Fluorescein angiography and spectral domain optical coherence tomography are highly sensitive methods used in detecting macular edema in patients with uveitis, but they might fail to be efficient in this if used independently. Optical coherence tomography is a more informative method, especially in diagnosing diffuse macular edema.

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Spectral-domain optical coherence tomography and fluorescein angiography features of cystoid macular edema with serous retinal detachment secondary to intracameral cefuroxime administration

JCRS Online Case Reports ◽

10.1016/j.jcro.2016.10.004 ◽

2016 ◽

Vol 4 (4) ◽

pp. 84-89 ◽

Cited By ~ 2

Author(s):

Giuseppe D'Amico Ricci ◽

Giulia Airaghi ◽

Francesco Boscia ◽

Paola Carlino ◽

Mario Sini ◽

...

Keyword(s):

Optical Coherence Tomography ◽

Retinal Detachment ◽

Fluorescein Angiography ◽

Macular Edema ◽

Cystoid Macular Edema ◽

Serous Retinal Detachment ◽

Spectral Domain ◽

Optical Coherence

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Patterns of Macular Edema in Uveitis as Diagnosed by Optical Coherence Tomography in Tertiary Eye Center

Nepalese Journal of Ophthalmology ◽

10.3126/nepjoph.v10i1.21687 ◽

2018 ◽

Vol 10 (1) ◽

pp. 39-46 ◽

Cited By ~ 1

Author(s):

Sharad Gupta ◽

Dev Narayan Shah ◽

Sagun Narayan Joshi ◽

Manoj Aryal ◽

Lila Raj Puri

Keyword(s):

Optical Coherence Tomography ◽

Macular Edema ◽

Serous Retinal Detachment ◽

Posterior Uveitis ◽

Invasive Technique ◽

Optical Coherence ◽

Fundus Fluorescein Angiography ◽

Cross Sectional ◽

Female Ratio ◽

Uveitic Macular Edema

Aim: The aim of the study is to classify the patterns of uveitic macular edema using Optical Coherence Tomography as a diagnostic tool.Methodology: It is the Descriptive, cross-sectional study. All patients fulfilling the diagnostic criteria with Optical coherence tomography diagnosed macular edema were enrolled from 1 January 2012 to 30 June 2013. Patterns of uveitic macular edema were classified.Results: A total of 65 eyes of 47 patients were included. Twenty eight (59.57%) were male. The male to female ratio was 1.5:1. The mean age was 38 years (SD 14.68). Twenty nine patients (61.71%) had unilateral involvement and 18 (38.29%) had bilateral involvement. Forty five eyes of 33 cases (69.23%, 70.21%) had intermediate uveitis, followed by 10 eyes of 7 cases (15.38, 14.9%) of posterior uveitis, 6 eyes of 5 cases (9.23%, 10.63 %) of anterior uveitis and 4 eyes of 2 cases (6.16%,4.2%) of pan-uveitis. Patterns of macular edema were classified: diff use macular edema (DME), cystoid macular edema (CME) and serous retinal detachment (SRD) of which 35 (53.84%) eyes had CME. The etiological diagnosis was found in 7(14.90 %) out of 47 patients.Conclusion: A significant percentage of cases were idiopathic. Macular edema may go unnoticed unless OCT is performed. Macular detachment is an important feature of macular edema that affects visual acuity and is not readily detected by Fundus Fluorescein Angiography (FFA). Optical coherence tomography (OCT) is safe and non-invasive technique and has the potential for measuring changes in retinal thickness and axial extent of edema.

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External limiting membrane: retinal structural barrier in diabetic macular edema

International Journal of Retina and Vitreous ◽

10.1186/s40942-021-00284-x ◽

2021 ◽

Vol 7 (1) ◽

Author(s):

Sandeep Saxena ◽

Levent Akduman ◽

Carsten H. Meyer

Keyword(s):

Optical Coherence Tomography ◽

Macular Edema ◽

Diabetic Macular Edema ◽

Spectral Domain ◽

Optical Coherence ◽

Barrier Effect ◽

External Limiting Membrane ◽

Ellipsoid Zone ◽

Structural Barrier ◽

Sd Oct

AbstractAdvances in spectral-domain optical coherence tomography (SD-OCT) technology have enhanced the understanding of external limiting membrane (ELM) and ellipsoid zone (EZ) in diabetic macular edema. An increase in VEGF has been demonstrated to be associated with sequential ELM and EZ disruption on SD-OCT. An intact ELM is a prerequisite for an intact EZ in DME. Anti-VEGF therapy leads to restoration of barrier effect of ELM. The ELM restores first followed by EZ restoration.

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Fundus autofluorescence and spectral domain optical coherence tomography in uveitic macular edema

Graefe s Archive for Clinical and Experimental Ophthalmology ◽

10.1007/s00417-009-1149-8 ◽

2009 ◽

Vol 247 (12) ◽

pp. 1685-1689 ◽

Cited By ~ 25

Author(s):

Martin Roesel ◽

Andreas Henschel ◽

Carsten Heinz ◽

Martha Dietzel ◽

Georg Spital ◽

...

Keyword(s):

Optical Coherence Tomography ◽

Macular Edema ◽

Fundus Autofluorescence ◽

Spectral Domain ◽

Optical Coherence ◽

Uveitic Macular Edema

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Optical coherence tomography findings predictive of response to treatment in diabetic macular edema

Journal of International Medical Research ◽

10.1177/0300060518798503 ◽

2018 ◽

Vol 46 (11) ◽

pp. 4455-4464 ◽

Cited By ~ 5

Author(s):

Young Joo Cho ◽

Dong Hyun Lee ◽

Min Kim

Keyword(s):

Optical Coherence Tomography ◽

Macular Edema ◽

Diabetic Macular Edema ◽

Serous Retinal Detachment ◽

Intravitreal Bevacizumab ◽

Internal Limiting Membrane ◽

Response To Treatment ◽

Optical Coherence ◽

Sd Oct

Objective To evaluate the short-term efficacy of intravitreal bevacizumab (IVB) and posterior sub-tenon triamcinolone injections (PSTI) on the basis of spectral-domain optical coherence tomography (SD-OCT) patterns in diabetic macular edema (DME). Methods We retrospectively reviewed 73 eyes of 73 patients with DME. Based on the presence of serous retinal detachment (SRD), eyes were categorized into two groups, and either IVB or PSTI treatment was performed. Central macular thickness (CMT) and the degree of SRD were assessed preoperatively and 1 month postoperatively. The severity of intraretinal edema was approximated based on the distance from the external limiting membrane to the internal limiting membrane. Results In eyes with SRD, reduction of SRD was greater with IVB than with PSTI. Moreover, reduction of intraretinal edema was greater with PSTI than with IVB. In eyes without SRD, PSTI achieved greater CMT reduction, compared with IVB. Conclusions In DME patients with SRD, IVB achieved greater reduction of SRD, compared with PSTI; however, intraretinal edema responded more favorably to PSTI, regardless of the presence of SRD. Our results suggest that the classification of DME based on OCT findings may be useful to predict responses to IVB or PSTI treatments.

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Macular edema with serous retinal detachment post-phacoemulsification followed by spectral domain optical coherence tomography: a report of two cases

BMC Research Notes ◽

10.1186/s13104-015-1639-1 ◽

2015 ◽

Vol 8 (1) ◽

Cited By ~ 10

Author(s):

Hui Xiao ◽

Xing Liu ◽

Xinxing Guo

Keyword(s):

Optical Coherence Tomography ◽

Retinal Detachment ◽

Macular Edema ◽

Serous Retinal Detachment ◽

Spectral Domain ◽

Optical Coherence

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TO ASSESS REDUCTION IN MACULAR EDEMA BY SPECTRAL DOMAIN OPTICAL COHERENCE TOMOGRAPHY (SD-OCT) FOLLOWING INJECTION OF BEVACIZUMAB IN CASES OF CENTRAL RETINAL VEIN OCCLUSION (CRVO)

International Journal of Advanced Research ◽

10.21474/ijar01/13272 ◽

2021 ◽

Vol 9 (08) ◽

pp. 347-351

Author(s):

Manjula Patnana ◽

◽

Nirmala Jyothi Pamu ◽

Shashwati Bhushan ◽

Ramakrishna Chatti ◽

...

Keyword(s):

Optical Coherence Tomography ◽

Macular Edema ◽

Retinal Vein Occlusion ◽

Central Retinal Vein Occlusion ◽

Macular Oedema ◽

Spectral Domain ◽

Optical Coherence ◽

Vein Occlusion ◽

Central Retinal Vein ◽

Sd Oct

Aim: To study the reduction in macular oedema in Central Retinal Vein Occlusion cases following Intravitreal injection of Bevacizumab using Spectral Domain Optical Coherence Tomography. Methods: 50 patients diagnosed with Central Retinal Vein Occlusion with macular oedema of more than 300 microns on Spectral Domain Optical Coherence Tomography ( SD-OCT) ,who attended to Out patient Department of Government Regional Eye Hospital (GREH) between January 2020 to June 2020 were administered Intravitreal Injection of Bevacizumab (Avastin) 1.25mg in 0.05ml. Re-injections were given if SD-OCT showed persistence of macular oedema. In follow up visits, patients were evaluated with SD-OCT and Central macular thickness (CMT) was measured every month till 6 months from the date of first injection. Results: Out of 50 cases included in the study, there was reduction in macular oedema in 45 (90%) cases and 5% had persistence of macular edema. Conclusion: Intravitreal Bevacizumab is a safe and effective modality of treatment for reducing macular edema due to Central Retinal Vein Occlusion as per our study.

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